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nadeemshaikh.bsky.social

@nadeemshaikh.bsky.social
107 followers 34 following 29 posts

Staff Scientist, Barts Cancer Institute QMUL

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Nitika Taneja @TanejaLab @nitikataneja.bsky.social · 01/07/2026
Very excited to share our new Nature study! We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg Huge thanks to all our collaborators and co-authors!
nature.com
Replication-stress-induced chromatin loops protect fork stability - Nature
Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.
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Mcclelland lab @mcclellandlab.bsky.social · 24/06/2026
Audrey, superstar postdoc in my lab is sadly moving on but not before seeing her first author work published! www.linkedin.com/posts/audrey...
linkedin.com
Replication origin firing capacity indicates ATR inhibitor sensitivity - Nature Communications | Audrey Lumeau
We are thrilled to share that our latest work has been published in Nature Communications! 🎉 In our study, we identify replication origin firing capacity as a key determinant of cellular sensitivity ...
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 09/06/2026
Fantastic experience chairing and organising inaugural London Genome Instability Conference (LOGIC) at @qmbci.bsky.social with @audreylumeau.bsky.social & @mollyguscott.bsky.social , brilliant talks on DNA damage, cancer initiation and genome evolution. Looking forward to doing it again next year!
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Cell - a Cell Press journal @cp-cell.bsky.social · 19/05/2026
Now online! Genome instability triggers intercellular DNA transfer between human cells
dlvr.it
Genome instability triggers intercellular DNA transfer between human cells
Mammalian cells can pass damaged pieces of their genome directly to neighboring cells via contact-dependent, nanotube-like connections. These transferred DNA fragments persist and function, revealing an unexpected route by which genome damage can propagate between cells.
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Trevor Graham @trevorgraham.bsky.social · 09/04/2026
If you work on quantitative cancer genomics, please consider submitting an abstract for our next "Cancer Population Genetics Club" #CANPOP meeting hosted @icr.ac.uk on 15 June 2026. CANPOP is free to attend. Registration & abstract submission here: docs.google.com/forms/d/e/1F...
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Zha Lab @zhalab.bsky.social · 05/04/2026
Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/... Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank Dr. Geunil Yi, for generating the illustration for all structural models.
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 04/02/2026
Excited for this film showcasing the important work my lab @mcclellandlab.bsky.social and other labs do at @qmbci.bsky.social . Attacking cancer from all angles with 1st class research by some amazing colleagues
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 01/02/2026
Drs Without Borders refused to hand over staffing lists to Israel because they have habit of targeted murder of medical staff: Israel then bans the medical charity from Gaza. Keep that in mind next time you interact with Israeli institutions www.bbc.co.uk/news/article...
bbc.co.uk
Israel to ban MSF from working in Gaza over refusal to provide staff list
Medical charity Medicine Sans Frontières said it would not share the list as it had not been able to ensure staff would remain safe.
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Trevor Graham @trevorgraham.bsky.social · 16/01/2026
Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...
jobs.icr.ac.uk
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...
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Job Dekker @jobdekker.bsky.social · 17/12/2025
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
nature.com
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use&nbsp;of genomic assays and computational methods to measure&nbsp;genome folding and then&nbsp;predict genomic structure&nbsp;from DNA sequence, facilitatin...
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 03/11/2025
Deadline is very soon (12pm November 5th) so get those applications in for a PhD position at Barts Cancer Institute working on radiotherapy resistance , copy number alterations and chromosomal instability !
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 31/10/2025
It’s time for academics and academic institutions to do the right thing www.soas.ac.uk/about/news/s...
soas.ac.uk
Senate statement on Gaza, Palestine
The Senate has published a ‘Senate Statement on Scholasticide in Gaza, Palestine’.
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Iva Tolić @ivatolic.bsky.social · 21/10/2025
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com doi.org/10.1038/s414... doi.org/10.1038/s414...
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Eva Petermann @petermannlab.bsky.social · 21/10/2025
A follow-up PhD project is now available: www.findaphd.com/phds/project...
findaphd.com
Regulation of Ribonuclease H2 for control of R-loops and genome stability at University of Birmingham on FindAPhD.com
PhD Project - Regulation of Ribonuclease H2 for control of R-loops and genome stability at University of Birmingham, listed on FindAPhD.com
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Dr Tanya Soliman @drtanyasoliman.bsky.social · 02/10/2025
Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
colcc.ac.uk
2026 BLiC PhD Project Soliman
Targeting a cell cycle vulnerability in TP53 mutant cancers Primary supervisor: Tanya Soliman, Queen Mary University of London Secondary supervisor: Miraz Rahman, King's College London Project To ...
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 02/10/2025
Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 24/09/2025
Ultimate dream - scientific work leading to major impact on people’s lives, the researchers and Drs involved must be over the moon to treat such a difficult and horrendous disease www.bbc.co.uk/news/article...
bbc.co.uk
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
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Eric Joyce @ericjoyce.bsky.social · 16/09/2025
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-f...
ericjoycelab.com
Oligopaint Probe Requests
In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 16/09/2025
@mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 02/09/2025
About time academics showed some moral fibre www.uu.nl/en/news/utre...
uu.nl
Utrecht University will not enter into any new collaborations with Israeli organizations until further notice
Utrecht University has decided to suspend all new collaborations with Israeli organizations until a committee can provide guidance on potential partners.
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 26/07/2025
Ever more depraved , like real world Squid Games, they should be relegated to pariah status www.bbc.co.uk/news/article...
bbc.co.uk
Gaza aid site offered a 'women only' day. It didn't stop the killing
Families say mothers Mary Sheikh al-Eid and Khadija Abu Anza were shot while seeking aid from GHF station in southern Gaza.
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Iain Cheeseman @iaincheeseman.bsky.social · 23/07/2025
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...
biorxiv.org
Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
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Eva Petermann @petermannlab.bsky.social · 23/07/2025
We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...
nature.com
Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress - Oncogene
Oncogene - Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 22/07/2025
It’s starting 😞 12 children, 21 adults starved to death by Israel. www.bbc.co.uk/news/article...
bbc.co.uk
Gaza health ministry says 33 people died from malnutrition in 48 hours
Fifteen deaths have been reported over the past day, the Hamas-run ministry says, as the UN warns of
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 15/07/2025
Great talk by @susanagodinho.bsky.social at London Cell Club today
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 13/07/2025
Two years ago, being accused of bombing a hospital was met with horror and denials. Now, bombing children is met with a shrug www.bbc.co.uk/news/article...
bbc.co.uk
Gaza officials say children killed in strike as Israeli military admits 'error'
Six children waiting for water are among those killed in an Israeli air strike, emergency service officials say.
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Alexander Stein @alexsteinresearch.bsky.social · 29/05/2025
Interested in population genetics of cancer? If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!
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JStark lab @jstarklab.bsky.social · 22/05/2025
We have a new study out - Distinct functions of PAXX and MRI during chromosomal end joining: iScience www.cell.com/iscience/ful...
cell.com
Distinct functions of PAXX and MRI during chromosomal end joining
A key step of Canonical-Nonhomologous End Joining is synapsis of DNA double strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this pr...
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Andreas Panagopoulos @apanagopoulos.bsky.social · 21/05/2025
Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...
doi.org
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
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dfachinetti.bsky.social @dfachinetti.bsky.social · 21/05/2025
Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician. You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 20/05/2025
www.theguardian.com/commentisfre...
theguardian.com
A moment of judgment has come at last: not just for Netanyahu but for his enablers | Owen Jones
Israel’s renewed assault on Gaza has prompted international condemnation, but many of those critics will face their own reckoning, says Guardian columnist Owen Jones
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Barts Cancer Institute (Queen Mary University of London) @qmbci.bsky.social · 20/05/2025
📰 New research shows women of African and South Asian ancestry tend to develop and die of breast cancer at a younger age. 🎥 Prof Claude Chelala at BCI @qmul.ac.uk discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances. 🧪 #medsky #oncosky
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Cold War Steve @coldwarsteve.bsky.social · 19/05/2025
Gary Lineker leaving BBC. Director General Tim Davie sweeps a killed Palestinian child (a model of one) under a rug.
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The Guardian @theguardian.com · 10/05/2025
If you were shocked by my film on Israeli settlers in the West Bank, you haven’t been paying attention | Louis Theroux
theguardian.com
If you were shocked by my film on Israeli settlers in the West Bank, you haven’t been paying attention | Louis Theroux
The response to The Settlers has been humbling. But the ongoing displacement and intimidation of Palestinians is more severe than we could capture, says documentary presenter Louis Theroux
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Financial Times @financialtimes.com · 07/05/2025
Opinion from the FT's Editorial Board: 'The US and European countries that tout Israel as an ally that shares their values have issued barely a word of condemnation. They should be ashamed of their silence, and stop enabling Netanyahu to act with impunity.' www.ft.com/content/f5fd...
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Michelle Lockley @mlockley.bsky.social · 30/04/2025
Can we use the power of evolution to improve ovarian cancer treatment? Our latest paper says yes! Online now at Cancer Research. Thanks to @trevorgraham.bsky.social coauthors and @cancerresearchuk.org for funding.
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Barbara Marte @barbmarte.bsky.social · 15/04/2025
this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.
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Veronica Rendo @vrendo.bsky.social · 19/03/2025
📣 Online now! Our study shows how recurrent focal deletions constitute a mechanism by which cancer cells can dampen toxicity due to gene amplification. www.cell.com/cell-genomic... 🧵👇:
cell.com
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications, suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9 cell line mod...
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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 02/04/2025
Fifteen ambulance staff slaughtered and then hidden in mass grave by Israeli army. www.bbc.co.uk/news/article...
bbc.co.uk
Survivor challenges Israeli account of attack on Gaza ambulances
Palestinian paramedic Munther Abed rejects Israel's assertion that the vehicles approached troops with their lights off.
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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 15/03/2025
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social www.science.org/doi/10.1126/...
science.org
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
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Prem Thakker ツ @premthakker.bsky.social · 24/03/2025
BREAKING: Yuval Abraham, co-director of Oscar-winning documentary "No Other Land," says Israeli settlers beat his co-director Hamdan Ballal, injuring his head and stomach — and then Israeli soldiers invaded the ambulance he was in and seized him. Ballal's whereabouts are now unknown.
Tweet from Yuval Abraham:
"A group of settlers just lynched Hamdan Ballal, co director of our film no other land. They beat him and he has injuries in his head and stomach, bleeding. Soldiers invaded the ambulance he called, and took him. No sign of him since."
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Krishnan Guru-Murthy @krishgm.bsky.social · 18/03/2025
Yesterday David Lammy was unequivocal that Israel is breaking international law. Today No 10 contradicts that and says it is merely “at risk of breaching” the law. It is an extraordinary position to put the Foreign Secretary in - who will now have to say why he was wrong, or why No 10 is wrong.
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Middle East Eye (Unofficial) @middleeasteye-rss.bsky.social · 10/03/2025
Nearly 100 Palestinians killed in West Bank by Israeli attacks in 2025 - www.middleeasteye.net/live-blog/liv…
middleeasteye.net
Nearly 100 Palestinians killed in West Bank by Israeli attacks in 2025
<span class="field field-title">Nearly 100 Palestinians killed in West Bank by Israeli attacks in 2025</span> <span class="field field-uid"><a title="View user profile." href="https://www.middleeasteye.net/users/bilge-kotan" lang about="https://www.middleeasteye.net/users/bilge-kotan" typeof="schema:Person" property="schema:name" datatype>Bilge Kotan</a></span> <span class="field field-created"><time datetime="2025-03-10T11:12:12+00:00" title="10 March 2025 11:12 GMT">Mon, 03/10/2025 - 11:12</time> </span> <div class="field field-field-text"><p>At least 97 Palestinians were killed by the Israeli army and settler attacks this year, according to the Palestinian health ministry.</p> <p>The ministry said that the figure includes 16 minors and three women.</p> </div>
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Trevor Graham @trevorgraham.bsky.social · 10/03/2025
We have an opening in our #DataScience core @icr.ac.uk. The post will work on a breadth of topics across #cancer biology, but expertise in spatial data, single cell and data integration are priorities. Details here: jobs.icr.ac.uk/vacancies/11... @jobrxiv.bsky.social
jobs.icr.ac.uk
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton. Salary Range: Commencement on the salary range is subject to comparable skills and experience. Future progression is based ...
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Mcclelland lab @mcclellandlab.bsky.social · 07/03/2025
Happy to post our first preprint in a while! www.biorxiv.org/content/10.1.... This was a slightly new direction for us, spearheaded by amazing post-doc @audreylumeau.bsky.social. Short thread to follow 🧬
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bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · 01/03/2025
High levels of DNA replication initiation factors indicate ATR inhibitor sensitivity via excessive origin firing www.biorxiv.org/content/10.1101/202…
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Show Israeli Genocide the Red Card @redcardglasgow.bsky.social · 23/02/2025
Hibs fans yesterday showed Israeli Genocide the Red Card 👏🟥🇵🇸
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bellellilab.bsky.social @bellellilab.bsky.social · 21/02/2025
We have another PhD project at @qmbci.bsky.social, within @cruk-cityoflondon.bsky.social RadNET, to understand how POLE3 promotes Double Strand Break repair and resistance to radiotherapy ! get in touch if you are interested in a PhD in genome stability ! crukradnet.colcc.ac.uk/phd-students...
crukradnet.colcc.ac.uk
Investigating the role of POLE3 in resistance to ionizing radiation treatment - CRUK RadNet
Investigating the role of POLE3 in resistance to ionizing radiation treatment Primary supervisor: Roberto Bellelli, Queen Mary University of London Secondary supervisor: Graeme Hewitt, King’s College ...
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Soni Lacefield @lacefieldlab.bsky.social · 21/02/2025
Check out our super cool paper on aneuploidy in cells lacking Bub3. Congratulations to fantastic student Pallavi Gadgil and alum Olivia Ballew. journals.plos.org/plosgenetics...
journals.plos.org
Aneuploidy of specific chromosomes is beneficial to cells lacking spindle checkpoint protein Bub3
Author summary Accurate chromosome segregation is crucial for the proper development of all living organisms. Errors in chromosome segregation can lead to aneuploidy, characterized by an abnormal numb...
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The EMBO Journal @embojournal.org · 10/02/2025
Proteogenomic analysis of evolved aneuploid cell lines & primary tumors reveals cancer adaptive strategies for alleviating aneuploidy consequences – including increased expression of DNA replication & repair factors & of FOXM1 targets Zuzana Storchova and coworkers www.embopress.org/doi/full/10....
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