Children’s Medical Center Research Institute at UT Southwestern (CRI) is a joint venture of UT Southwestern Medical Center and Children’s ...

Glioma-derived guanidinoacetate depolarizes neighboring neurons through γ-aminobutyric acid (GABA) A receptors, and depleting this metabolite reduces both neuronal activity and glioma growth.

Study from McBrayer Lab shows brain tumors exploit metabolite to activate nearby neurons DALLAS – Sept. 15, 2026 – Virtually all high-grade, aggressive gliomas in adults accumulate massive amounts of ...

A genetic mouse model of IDH-mutant glioma responds to mutant IDH inhibitor (mIDHi) and shows that prior mIDHi treatment improves response to chemoradiation.

Explore the causes and impact of aneuploidy in cancer, aging, and development at this global research conference.

Science study shows alpha-ketoglutarate supplementation may delay progression of GPT2 deficiency, rare inborn error of metabolism DALLAS – July 16, 2026 – Scientists at Children’s Medical Center Resea...

Targeting transcription machinery could disturb ecDNA maintenance, reduce oncogenicity Dallas – June 24, 2026 – Extrachromosomal DNA (ecDNA) — circular, fractured chromosomal DNA found in the nucleus ...

DNA can voyage along intercellular highways called tunneling nanotubes. It’s a phenomenon that could potentially spread tumor DNA to healthy cells.

Children’s Research Institute scientists discover that DNA transferred between cells can be inherited, remain biologically active DALLAS – May 19, 2026 – Scientists at Children’s Medical Center Resear...

McBrayer Lab uses their new nitrogen metabolism profiling platform, organoid model to discover modification of enzyme CAD activates de novo pathway A cell’s development stage intrinsically determines ...

The National Academy of Sciences (NAS) today elected three UT Southwestern Medical Center scientists into its membership. Election to the NAS is one of the highest honors in the United States for Amer...

Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the ph...

Henry De Belly, Ph.D., the newest CRI faculty member, launched the De Belly Lab in early 2026 and joins the CRI Tissue Regeneration Program. Henry grew up in France and earned a bachelor’s in immunolo...

Somatic genetics uses tissue mutations to understand aging, reveal disease mechanisms, and guide new therapies.

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UT Southwestern Medical Center has received an award from the Advanced Research Projects Agency for Health (ARPA-H) to develop livers using patients’ own cells and an innovative three-dimensional (3D)...