Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while ...

Assistant/Associate Professor, Chemical Biology job

Cyclic and mirror-image variants of de novo-designed proteins effectively bind and clear small-molecule drugs in vivo in less than 30 min, highlighting the applicability of computational tools to prod...

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Here we describe ProtacID, a flexible BioID (proximity-dependent biotinylation)-based approach to identify PROTAC-proximal proteins in living cells. ProtacID analysis of VHL- and CRBN-recruiting PROTA...

Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been assoc...

Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

In this review Ebner et al. summarize and discuss the rapidly increasing knowledge regarding the mechanisms of lysosomal lipid turnover and export as well as the pathways for the homeostatic control a...

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...

Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...

What if the greatest breakthroughs in research were locked away, inaccessible to the world? For Aled Edwards, this wasn’t just a hypothetical but a reality he encountered early in his career. In this ...

In a study published today in the Journal of Clinical Investigation, Fred Hutch Cancer Center cancer chemical biologist Behnam Nabet and his collaborators describe how they used targeted protein degra...

Pioneering crystallographer Helen Berman helped to set up the massive collection of protein structures that underpins the Nobel-prize-winning tool’s success.

The nascent field of targeted protein degradation (TPD) could revolutionize biomedicine due to the ability of degrader molecules to selectively modulate disease-relevant proteins. A key limitation to ...

Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharm....

What if the greatest breakthroughs in research were locked away, inaccessible to the world? For Aled Edwards, this wasn’t just a hypothetical but a reality he encountered early in his career. In this ...

Homologous to E6AP C-Terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control or protein quality control. Tom1 is one of five HECT ubiquitin E3 lig...

We are now in the middle of a so-called “fourth wave” of drug innovation: multispecific medicines aimed at diseases and targets previously thought to be “undruggable”; by inducing proximity between tw...

The story of research in menin and its relation to cancer — from early efforts to understand how the cell makes use of menin, to explorations of the cell machinery operated by menin, to the developmen...