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Chemical Probes Portal @chemicalprobes.org · 17/07/2026

25 years after the human genome sequence, where are we with precision cancer medicine? Prof Paul Workman reflects on the breakthroughs that have transformed cancer drug discovery, from targeted therapies and AI approaches to the role of chemical probes in understanding and validating new targets.

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Chemical Probes Portal @chemicalprobes.org · 09/07/2026

The 11th #ChemicalProbesPortal Hackathon is underway today at the Department of Chemistry, @newcastleuni.bsky.social ! Students and experts working together to evaluate chemical probes. Many thanks to the @mosmedcdt.bsky.social CDT for supporting today’s event! #DrugDiscovery #OpenScience

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Chemical Probes Portal @chemicalprobes.org · 06/07/2026

Professor Paul Workman will deliver a keynote at #NextGenerationCancerTherapeutics in Houston this October, joining leaders from academia, biotech & pharma to explore advances in precision medicine, immunotherapy, AI-enabled drug discovery & next-generation cancer therapeutics.

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Chemical Probes Portal @chemicalprobes.org · 12/06/2026

Just a few days until Discovery & Development Europe 2026 in Berlin! Join us for Paul Workman’s keynote lecture and the Target Identification & Validation Track, co-organised by Susanne Müller-Knapp and supported by ELRIG. See you there on 15–16 June! #DrugDiscovery #ChemicalBiology #ELRIG

oxfordglobal.com

Drug Discovery Europe 2026

Pushing traditional boundaries in pharmaceutical science by accelerating the discovery of novel therapeutics

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Chemical Probes Portal @chemicalprobes.org · 03/06/2026

The 10th #ChemicalProbes Hackathon was a great success in Naples! 👥 20 participants 🎓 7 expert reviewers 📝 16 new probe reviews produced ⏰ All in just 4 hours Thanks to @EUFEPS and SITELF for hosting—and for the real Italian espresso machine at coffee break! ☕🇮🇹

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Chemical Probes Portal @chemicalprobes.org · 23/04/2026

Heading to Discovery & Development Europe 2026 in Berlin 🇩🇪 Proud that our Portal Director, Paul Workman, will deliver a keynote, and Susanne Müller-Knapp will co-organise the Target Identification & Validation Track (with ELRIG). 📅 15–16 June #DrugDiscovery #ChemicalBiology #ELRIG Link 👇

oxfordglobal.com

Discovery & Development Europe - Book Now

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Chemical Probes Portal @chemicalprobes.org · 02/03/2026

Breakthrough Aurora A PROTAC on the Chemical Probes Portal ⭐⭐⭐⭐ CCT400028 @icr.ac.uk London overcomes the hook effect, delivers >120h stability, is highly selective, and includes a matched inactive control. Powering paediatric cancer research. #ChemicalProbes #PROTAC Read more 👇

icr.ac.uk

Researchers overcome major obstacle in targeted protein degradation

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Chemical Probes Portal @chemicalprobes.org · 12/02/2026

A successful PROTAC Hackathon hosted at the@crick.ac.uk: • 34 participants • 24 reviews generated • 100% reported improved understanding Organised by the Chemical Probes Portal with academic & industry collaboration. Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹 #ChemicalProbes #PROTACs #EUFEPS

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Chemical Probes Portal @chemicalprobes.org · 05/02/2026

Excited about tomorrow! A full house at @crick.ac.uk for the 9th Chemical Probe Hackathon, with experts from GSK, @icr.ac.uk & TheCrick working with PhDs & postdocs to review chemical probes and improve research quality. #ChemicalProbes #ChemBio #OpenScience #Hackathon

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Chemical Probes Portal @chemicalprobes.org · 31/12/2025

Warm congratulations to Professor Paul Workman on receiving an OBE in the 2026 New Year Honours for services to cancer research. A leader in precision medicine and co-founder of the Chemical Probes Portal, his work has had a lasting impact on chemical biology, drug discovery, and patient benefit. 🎉

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Chemical Probes Portal @chemicalprobes.org · 21/12/2025

Season's Greetings from The Chemical Probes Portal mailchi.mp/cd05056fa93f...

mailchi.mp

Season's Greetings from The Chemical Probes Portal

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Chemical Probes Portal @chemicalprobes.org · 20/10/2025

We brought together 22 researchers & 6 experts for a full day of evaluating GPCR and ion channel probes — and completed 26 reviews! Lots of learning, laughter, and deep discussions about what makes a great chemical probe. #ChemicalProbes #OpenScience #DrugDiscovery #GPCR #IonChannels

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Chemical Probes Portal @chemicalprobes.org · 14/10/2025

We’re in Oxford today for the 1st UK Chemical Probes Hackathon! 🎯 Postdocs & PhD students join experts to assess GPCR probes and improve research quality. Hosted by @ChemProbes + @UniofOxford #ChemicalProbes #GPCRs #DrugDiscovery

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Chemical Probes Portal @chemicalprobes.org · 06/10/2025

Happening today and tomorrow (7 October)! Join Müge Sarper, Scientific Coordinator of the Chemical Probes Portal at the @icr.ac.uk, at the poster sessions of the 5th Crick International Cancer Conference. Stop by to learn how the Portal supports cancer and biomedical research. #CrickCancerConf

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Chemical Probes Portal @chemicalprobes.org · 22/09/2025

Excited to share that Müge Sarper, Scientific Coordinator of the Chemical Probes Portal at the Institute of Cancer Research, London (ICR), will present a poster at the 5th Crick International Cancer Conference (5–7 October 2025, London). www.crick.ac.uk/whats-on/5th...

crick.ac.uk

5th Crick International Cancer Conference

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Chemical Probes Portal @chemicalprobes.org · 07/08/2025

🎉 The Chemical Probes Portal turns 10! We’re honoured to be featured in Dr Dan Erlanson’s latest Practical Fragments blog, reflecting on a decade of advancing chemical biology and open science. 🔗 Read the blog: practicalfragments.blogspot.com/2025/08/the-... #ChemicalProbes #Target2035

practicalfragments.blogspot.com

The Chemical Probes Portal turns ten. Use it!

Last week we highlighted a new tool to computationally predict whether a molecule might aggregate, thereby causing false positives. This do...

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Reposted by Chemical Probes Portal

Aled Edwards S.G. @aledmedwards.bsky.social · 23/07/2025

After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published. rdcu.be/exxi7

rdcu.be

Protein–ligand data at scale to support machine learning

Nature Reviews Chemistry - Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap...

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Chemical Probes Portal @chemicalprobes.org · 21/07/2025

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

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Chemical Probes Portal @chemicalprobes.org · 03/07/2025

New @ACSChemBio study provides strong evidence that the effects of CDK8/19 inhibitors CCT251545 and CCT251921 are on-target. Using CRISPR knockouts + phosphoproteomics, authors show transcriptional & antitumor effects depend on CDK8/19. 🔗 pubs.acs.org/doi/10.1021/... #ChemicalProbes #CDK8 #OnTarget

pubs.acs.org

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer

The Mediator complex is a regulator of gene expression, influencing chromatin structure and RNA polymerase II-mediated transcription. Its activity is controlled by a protein kinase module, which inclu...

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Chemical Probes Portal @chemicalprobes.org · 11/06/2025

📣 Happening today! Join the Babraham Distinguished Lecture with Prof Paul Workman | 1–2pm, 12 June 🧬 “Probing and drugging stress pathways: Chemical Biology and therapeutic discovery” #Cancer#StressResponse#DrugDiscovery#ChemicalBiology #TargetValidation#MolecularPharmacology #TranslationalResearch

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Chemical Probes Portal @chemicalprobes.org · 28/04/2025

Reminder: Tomorrow, Professor Paul Workman will give his Meet the Expert Lecture at #AACR: Personalized Molecular Medicine Enabled by Multidisciplinary Approaches to Cancer Drug Discovery and Clinical Development. Details: www.abstractsonline.com/pp8/#!/20273... #AACR2025 #CancerResearch

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Chemical Probes Portal @chemicalprobes.org · 16/04/2025

Have you caught Episode 6 of the #Target2035 Podcast? 🎙️ Danette Daniels (@ FoghornTx) joins Milka Kostic, to dive into the power of #ProteinDegradation – what sets degraders apart, why #TPD is surging, and how we speed discovery. Plus: championing #WomenInSTEM 💪

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Chemical Probes Portal @chemicalprobes.org · 15/04/2025

Capivasertib – the first-in-class AKT inhibitor – is now approved by NICE for NHS use in England & Wales, following FDA and EMA approvals for cancer treatment. #Oncology #CancerResearch #AKT #TargetedTherapy #NICE @icr.ac.uk www.icr.ac.uk/about-us/icr...

icr.ac.uk

ICR welcomes NICE recommendation of capivasertib for advanced breast cancer

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Chemical Probes Portal @chemicalprobes.org · 16/03/2025

🎧 New Target 2035 Podcast! Rachel Harding & Matthieu Schapira dive into #CACHEChallenges — a global effort to refine small-molecule discovery algorithms with real-world validation. 🔬 How does CACHE boost #DrugDiscovery? Find out: lnkd.in/gcwkUXup #AIinDrugDiscovery #OpenScience #MachineLearning

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Reposted by Chemical Probes Portal

Cheryl Arrowsmith @carrowsm.bsky.social · 02/03/2025

This excellent commentary is a must-read for cancer biologists (and all biologists, really). Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...

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Chemical Probes Portal @chemicalprobes.org · 12/03/2025

📢Looking ahead to #AACR25 in Chicago — only 6 weeks away! Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery. 📅 April 29, 2025 | ⏰ 5:00-5:45 PM Learn more👇 #CancerResearch

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Chemical Probes Portal @chemicalprobes.org · 11/03/2025

Congratulations to our Chemical Probes Portal Executive Director, Professor Paul Workman, on his election as a Fellow of the AACR Academy Class of 2025! 🎉 An incredible recognition of his lasting impact on cancer research. #AACR #CancerResearch #DrugDiscovery

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Chemical Probes Portal @chemicalprobes.org · 05/03/2025

The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes

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Chemical Probes Portal @chemicalprobes.org · 02/03/2025

We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅ 🔗 Supplementary material: ars.els-cdn.com/content/imag... #ChemicalProbes #DrugDiscovery #ChemicalBiology

ars.els-cdn.com

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Chemical Probes Portal @chemicalprobes.org · 28/02/2025

Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes

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Chemical Probes Portal @chemicalprobes.org · 24/02/2025

The brachyury structure, along with crystallographic fragment-based screening and enhanced compounds, may enable the development of chemical probes and future drugs. This approach could also be applied to other hard-to-drug transcription factors and proteins.

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Reposted by Chemical Probes Portal

The Institute of Cancer Research @icr.ac.uk · 21/02/2025

ICR's Professor Paul Workman, and researchers at @ox.ac.uk and @uncchapelhill.bsky.social have made a breakthrough that could lead to drugs for the 'undruggable' chordoma - the rare #BoneCancer that killed Paul's mother. Read more from Professor Workman here ⬇️ www.icr.ac.uk/research-and...

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Chemical Probes Portal @chemicalprobes.org · 20/02/2025

🔬 The Chemical Probes Hackathon is underway in Vienna! Experts from academia & industry, along with international students, are reviewing kinase inhibitors & PROTACs—advancing biomedical research through collaboration. Excited to see today’s findings! 🚀 #EUFEPS #chemicalprobes

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Chemical Probes Portal @chemicalprobes.org · 28/01/2025

🔬 Calling all PhD students & postdocs in chemistry/biology! Join us at the Chemical Probes Hackathon 🧪: 🗓️ Feb 20, 2025 | 10:00–14:30 📍 Vienna, Austria 💡 Evaluate chemical probes w/ experts & improve global science 🌍. 🎓 Earn a Certificate of Attendance! Learn more & register 👇

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Chemical Probes Portal @chemicalprobes.org · 24/01/2025

🎙️ New podcast episode alert! Professor Paul Workman joins Opher Gileadi on the #Target2035 podcast to dive into the science of chemical probes. 🧪 🔍 What makes a great probe? 🛑 Common lab mistakes. 🌐 Learn about the Chemical Probes Portal. 🎧 Listen now 👇

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Chemical Probes Portal @chemicalprobes.org · 10/01/2025

NXP800 is an analogue of CCT251236, also used in the paper, which is listed on the Portal as inhibitor of the HSF1 pathway. The new findings show therapeutic potential in prostate cancer no longer responsive to hormone therapy.

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Chemical Probes Portal @chemicalprobes.org · 07/01/2025

Chemical probes are vital for studying proteins & developing treatments, but misuse can mislead research. The Chemical Probes Portal offers free expert advice on selecting high-quality, potent, selective probes. Latest updates aim to boost research reliability. #DrugDiscovery

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Chemical Probes Portal @chemicalprobes.org · 27/12/2024

Season’s Greetings and Best Wishes for 2025 from the Chemical Probes Portal! ✨🔬

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Chemical Probes Portal @chemicalprobes.org · 17/12/2024

🌟 Exciting news! Introducing #MAINFRAME, a global #OpenScience network uniting #MachineLearning & #CompChem experts to drive innovation in #DrugDiscovery. 🚀 Their mission? Open-source algorithms, real-world benchmarking, and faster, affordable medicine development. Learn more👇

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Chemical Probes Portal @chemicalprobes.org · 11/12/2024

Paul Workman, Sharad Verma, Timothy A. Yap, and Jerome Mettetal discussed "Developing Efficacious Drugs with Better Combinability" in a plenary session at the AACR Conference on Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry. #AACRchem24 #AACRCICR

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Chemical Probes Portal @chemicalprobes.org · 11/12/2024

Paul Workman highlighted the importance of selectivity towards the protein target of interest – both for modern, molecularly-targeted drugs and also for high-quality chemical probes for use in laboratory exploration of protein function. #AACRchem24 @icrlondon.bsky.social @mdanderson.bsky.social

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Chemical Probes Portal @chemicalprobes.org · 24/11/2024

🧪 How can we develop efficacious drugs with better combinability? Join Paul Workman, Timothy A. Yap & Jerome Mettetal at @AACR’s #AACRchem24 conference (Dec 9–11) as they tackle this critical topic. Learn more: bit.ly/4gLZMYO

bit.ly

Program

Program details for Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry in association with AACR Chemistry in Cancer Research Working Group

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Chemical Probes Portal @chemicalprobes.org · 23/11/2024

🚨 Just Launched! Episode 1 of the Target 2035 Podcast Series 🎧 Join @LabScribbles as they chat with @CherylArrowsmi1, a trailblazer in chemical biology and co-founder of #Target2035. Discover the story behind this ambitious initiative for #OpenScience and #DrugDiscovery. 🎙️ Listen now: Link below 👇

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