Reposted by Moritz HunkelerMonte Rosa Therapeutics @monterosatx.com · 19/11/2025Through proteomic profiling of our proprietary compound library, our team identified a selective, fast, and potent molecular glue degrader that induces cereblon degradation via a novel mechanism. Read the full paper in @natcomms.nature.com: rdcu.be/eQKQk 032
Reposted by Moritz HunkelerBen Engel @cellarchlab.com · 30/09/2025EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬 The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩🔬🤓 25760
Moritz Hunkeler @moritzhunkeler.bsky.social · 14/09/2025Amazing, I wonder how many people are now sprinting back to some of their old data sets of small particles that they could never successfully process.. err, i have to go 🏃♂️💨 060
Moritz Hunkeler @moritzhunkeler.bsky.social · 15/05/2025Yes great, new grid boxes that have no space to write on. With lids that no standard tool can open. 👍 130
Moritz Hunkeler @moritzhunkeler.bsky.social · 03/01/2025Received program for amazing cryo-EM symposium 👍 It’s on a Saturday, 9-5 🤦🏻♂️ 100
Reposted by Moritz HunkelerLaurence Pearl 🔥 @laurencepearl.bsky.social · 31/12/2024Indulged in the popular German New Years Eve tradition of watching Dinner for One - you may wish to indulge, or not youtu.be/2pbJlHMpUlU?...youtu.beDinner for One - The OriginalYouTube video by Photography and Me 021
Moritz Hunkeler @moritzhunkeler.bsky.social · 03/12/2024My UBR4, despite being very active, always looked like garbage on the grids. Need to dig in here to find the secret sauce! Congrats to @micharapelab.bsky.social lab et al 100
Reposted by Moritz HunkelerMilka Kostic @milkakostic.bsky.social · 27/11/2024New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky. www.biorxiv.org/content/10.1...biorxiv.orgStructural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1Homologous to E6AP C-Terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control or protein quality control. Tom1 is one of five HECT ubiquitin E3 lig... 0103
Moritz Hunkeler @moritzhunkeler.bsky.social · 13/11/2024No answer on the other platform, so I ask here again: Is the 3DFSC server working for anybody? 100
Reposted by Moritz HunkelerSven Klumpe @svenklumpe.bsky.social · 24/02/2024Over 4 years in the making, I am extremely happy to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells: www.biorxiv.org/content/10.1... 56226
Reposted by Moritz HunkelerRémi Fronzes @fronzeslab.bsky.social · 08/11/2024Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC 7211076
Reposted by Moritz HunkelerBen Engel @cellarchlab.com · 19/07/2024Opening for an awesome group leader to join our community on the 5th/6th floor of the @biozentrum. We're looking for someone who brings an exiting biological program using a combo of structural biology, cellular imaging, and biophysics. Come join us!!🧪🧶🧬🔬👩🔬 www.biozentrum.unibas.ch/open-positio...biozentrum.unibas.chAssistant/Associate Professor in Structural Biology, Biological Imaging or Biophysics 039
Reposted by Moritz HunkelerSjors Scheres @sjorsscheres.bsky.social · 27/09/2023Read tomorrow's Nature to find out what we think 7 years of solving #cryoEM structures of brain-derived #amyloids has taught us about neurodegeneration, and where to go from here. With Michel Goedert and Ben Ryskeldi-Falcon, and very grateful to present and past group members. rdcu.be/dnaXd 2279
