Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be ac...

Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be ac...

'First DREAM Target 2035 Drug Discovery Challenge' (Synapse ID: syn65660836) is a project on Synapse. Synapse is a platform for supporting scientific collaborations centered around shared biomedic...

The future of drug discovery may be artificial intelligence (AI), but its present is not. AI is in its infancy in the field. To help AI mature, developers need nonproprietary, open, large, high-qualit...

'First DREAM Target 2035 Drug Discovery Challenge' (Synapse ID: syn65660836) is a project on Synapse. Synapse is a platform for supporting scientific collaborations centered around shared biomedic...

Chemical pollution is a global threat to human health, yet the toxicity mechanism of most contaminants remains unknown. Here, we applied an ultrahigh-throughput affinity-selection mass spectrometry (A...

By Max Morgan The pharmaceutical industry has faced a crisis of declining productivity in recent years. The number of new drugs coming to market has decreased, even as research and development costs...

A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target...

A critical assessment of computational hit finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target...

We are proud to announce the first three recipients of funding via our Developing Medicines through Open Science program. These grantees are working towards treatments and cures for three rare disease...

Helicases are essential motor enzymes that couple nucleoside-triphosphate hydrolysis with DNA or RNA strand unwinding. Helicases are integral to replication, transcription, splicing, and translation o...

Aircheck for Artificial Intelligence-Ready CHEmiCal Knowledge bases

This study describes structures of the transcription factor brachyury revealing the mechanism of DNA recognition. They identify fragments using X-ray fragment screening and optimize these into potent ...

By Sofia Melliou

Dr. Alison Axtman, PhD, researches and provides chemical tools to the larger scientific community so that new therapeutic remedies can be developed

The Structural Genomics Consortium (SGC) is pleased to announce that Dr. Rachel Harding, Principal Investigator at SGC-Toronto, has been awarded a Canadian Institutes of Health Research (CIHR) Fall 20...

Members of the casein kinase 1 (CK1) family have emerged as key regulators of cellular signaling and as potential drug targets. Functional annotation of the 7 human isoforms would benefit from isoform...

Liver X receptor drives epithelial Areg-mediated intestinal regeneration, while preventing tumour growth through adaptive immune responses.

Despite extensive research on covalent kinase inhibitors, much of the protein kinases’ “cysteinome” remains unexplored. Here, we outline a generalizable approach to sample ATP-site cysteines with fra....

Abstract. The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection

Small molecule degraders such as PROteolysis TArgeting Chimeras (PROTACs) and molecular glues are new modalities for drug development and important tools for target validation. When appropriately opti...

Academic and industry scientists collaborate on a new method to characterize research antibodies Structural Genomics Consortium researchers at The Neuro (Montreal Neurological Institute-Hospital) of M...

Health is core to our quality of life, yet millions worldwide lack treatments to diseases that threaten their lives or quality of life. For example, an estimated 400 million people worldwide live with...

Poorly performing antibodies contribute to the reproducibility crisis in biomedical research. The market offers millions of antibodies and validating them is a cumbersome process. Now, the non-profit ...

Chapel Hill, North Carolina – June 27, 2024 – The Structural Genomics Consortium (SGC) is thrilled to announce a new research collaboration with DiaGen AI Inc., an AI-driven protein design platform de...

As the Structural Genomics Consortium (SGC) enters its third decade, it is embarking on an ambitious goal: to become the world’s largest generator of open-source protein-ligand data. Recognizing the g...

Target 2035 is a global initiative that seeks to identify a pharmacological modulator of most human proteins by the year 2035. As part of an ongoing series of annual updates of this initiative, we sum...

Here the authors suggest that in Atypical Teratoid Rhabdoid Tumors, EZH2 inhibition triggers a viral mimicry response via the activation of genes with intronic IR-Alu elements. This response also invo...