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Aled Edwards S.G.

@aledmedwards.bsky.social
168 followers 36 following 116 posts

Scientist. Frog hunter. Founder and Chief Executive of Structural Genomics Consortium.

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Reposted by Aled Edwards S.G.
Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 11/04/2026
Congratulations to our Senior Scientists, Drs. Hansen He and Cheryl Arrowsmith for receiving AACR Scientific Achievement Awards in recognition of their outstanding contributions to cancer research. #AACR26
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Aled Edwards S.G. @aledmedwards.bsky.social · 06/02/2026
Very cool to be at an over-subscribed hands-on meeting organized by @chemicalprobes.org, GSK and @crick.ac.uk, at which trainees will be guided by experts to learn how to assess the quality of small molecule tools used in the literature. Dozens of Protacs will be assessed today.
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Reposted by Aled Edwards S.G.
Research at UHN @uhnresearch.ca · 20/01/2026
A Canadian-led collaboration is leading a global initiative to transform drug discovery with #AI and #OpenScience! 🍁 @uhn.ca, @sickkidsto.bsky.social & @thesgc.bsky.social, are partnering on a $26M grant to support the LIGAND-AI Project—an international effort to advance precision medicine.⬇️
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Aled Edwards S.G. @aledmedwards.bsky.social · 11/01/2026
Steve Kerr is an impressive individual. Wins with class, loses with class, and speaks the truth. m.youtube.com/watch?v=5tmX...
m.youtube.com
STEVE KERR calls US Government 'SHAMEFUL' for LYING about ICE shooting of Renee Nicole Good
YouTube video by Diario AS
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Aled Edwards S.G. @aledmedwards.bsky.social · 17/12/2025
After two years of method development, it’s out. Pretty excited about this method, which not only expedites hit-finding, but also expedites hit verification. www.nature.com/articles/s41...
nature.com
Enantioselective protein affinity selection mass spectrometry (E-ASMS) - Nature Communications
High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand d...
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Aled Edwards S.G. @aledmedwards.bsky.social · 07/12/2025
I don’t read any scientific papers in which the authors use too many significant digits in their figures. It’s a strong proxy indicator of shoddy science and shoddy thinking. On the up side, it means I only need to read a few papers a week.
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Aled Edwards S.G. @aledmedwards.bsky.social · 07/11/2025
I moved to Canada from Wales as a young boy, grew up here, and stayed. A great place to live, raise a family, and do science. We’re a multicultural country of immigrants, and that’s not bad, it’s our superpower. Come explore for yourself! @uhnresearch.ca @utoronto.ca www.science.org/content/arti...
science.org
Canada’s new budget aims to lure U.S. researchers to relocate
Spending plan also calls for smaller research spending cut than feared
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Reposted by Aled Edwards S.G.
Richard Sever @richardsever.bsky.social · 09/10/2025
AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...
blog.genesmindsmachines.com
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
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Aled Edwards S.G. @aledmedwards.bsky.social · 04/10/2025
Feel good story of day. Went to outdoor movie night at granddaughter’s school yesterday in downtown Toronto. The children and parents comprised a rainbow of colours, speaking a Babel of languages. It was so joyful watching all the children run and play together. Canada has done something right.
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Aled Edwards S.G. @aledmedwards.bsky.social · 27/09/2025
If anything, this analysis on “what would have happened if the NIH had spent 40% less over past years” underestimates the impact of NIH on innovation. The most valuable IP walks on two feet. And guess who paid for the training of many industry scientists? www.science.org/doi/10.1126/...
science.org
What if NIH had been 40% smaller?
Replaying history with less NIH funding shows widespread impacts on drug-linked research
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Aled Edwards S.G. @aledmedwards.bsky.social · 12/09/2025
In selecting an antibody to use for your experiment, you should look in the literature and find the one that one is most cited. NOT!
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Aled Edwards S.G. @aledmedwards.bsky.social · 06/09/2025
For the non-Canadians out there, one of our best just died. Ken Dryden was an athlete, scholar, public servant. Bill Bradley is the closest equivalent in the United States. Dryden was my childhood hero. You want to understand a lot about Canada, read his book “The Game”. www.cbc.ca/news/canada/...
cbc.ca
Tributes pour in for hockey legend, former politician and author Ken Dryden | CBC News
Tributes are pouring in from across Canada and beyond after former Montreal Canadiens goalie Ken Dryden — a legend of Canadian hockey — died at the age of 78.
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Reposted by Aled Edwards S.G.
Research at UHN @uhnresearch.ca · 05/09/2025
#ICYMI Congratulations to @uhn.ca’s Drs. Cheryl Arrowsmith and John Dick for receiving the Awards for Excellence in Cancer Research from the Canadian Cancer Society! Read more on their research and awards ➡️ www.uhnresearch.ca/news/recogni...
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Reposted by Aled Edwards S.G.
Matthieu Schapira @mattschap.bsky.social · 12/08/2025
CACHE 7 is launched with support from the @gatesfoundation.bsky.social and unpublished data from Damian Young at @bcmhouston.bsky.social, Tim Willson @thesgc.bsky.social and Neelagandan Kamaria InSTEM. Design selective PGK2 inhibitors. We'll test them experimentally. bit.ly/4lnVYOs
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Reposted by Aled Edwards S.G.
Elizabeth Picciuto @epicciuto.bsky.social · 11/08/2025
In 2016, before Trump secured the GOP nomination, the Boston Globe made a fictional dystopian front page of what a nightmare world it would be if Trump won. And those just pretty much are our actual headlines now.
A fake Boston Globe front page for April 2017. Headlines include, “deportations to begin: President Trump calls for tripling of ice force, riots continue,” “US soldiers refuse orders to kill Isis families,” “ market sink as trade wars loom,” “ new libel law targets ‘absolute scum’ in press” “ Trump on Nobel Prize shortlist,”
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Reposted by Aled Edwards S.G.
Drugs for Neglected Diseases initiative (DNDi) @dndi.org · 28/07/2025
#HepatitisC is a curable disease, but life-saving treatment is priced out of reach for millions of people who need it. On #WorldHepatitisDay, join us as we call for access to affordable treatments globally! 👉 Read more about the study presented at the 2025 #EASLCongress in May: bit.ly/4fdYoxS
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Aled Edwards S.G. @aledmedwards.bsky.social · 23/07/2025
After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published. rdcu.be/exxi7
rdcu.be
Protein–ligand data at scale to support machine learning
Nature Reviews Chemistry - Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap...
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Reposted by Aled Edwards S.G.
Chemical Probes Portal @chemicalprobes.org · 21/07/2025
🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk
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Reposted by Aled Edwards S.G.
Mark Lautens @marklautens.bsky.social · 16/07/2025
Come join our faculty. Rank is open (assistant, associate, full professor) in experimental physical chemistry. A department with a distinguished past and bright future.
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Aled Edwards S.G. @aledmedwards.bsky.social · 04/07/2025
Groan….
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Aled Edwards S.G. @aledmedwards.bsky.social · 01/07/2025
Not a minute goes by over the past 60 years that I have regretted my parents’ decision to move us to Canada. A country that is, and has always been, great. Happy Canada Day to all! 🇨🇦
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Aled Edwards S.G. @aledmedwards.bsky.social · 21/06/2025
This is heartbreaking, and shame on Trump, Musk and Rubio. But given USAID and the US people did a huge public service by investing in the infrastructure to distribute medicine in Africa, why can’t Canada step up, leverage this, and fund some of the programs? www.nytimes.com/2025/06/21/o...
nytimes.com
Opinion | The Waste Musk Created
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Reposted by Aled Edwards S.G.
Matthieu Schapira @mattschap.bsky.social · 16/06/2025
CACHE4 results are out! All previously known CBLCB ligands shared the same scaffold. Congrats to Keunwan Park who successfully designed a chemically novel series, to the experimental team at @thesgc.bsky.social and thanks to @conscience-network.bsky.social for greasing the wheels! bit.ly/4mYNe3r
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Aled Edwards S.G. @aledmedwards.bsky.social · 11/06/2025
Jays. So hot right now. Jays. #BlueJays @torontobluejays.bsky.social
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Aled Edwards S.G. @aledmedwards.bsky.social · 30/05/2025
Unbelievable www.nytimes.com/2025/05/29/w...
nytimes.com
White House Health Report Included Fake Citations
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Aled Edwards S.G. @aledmedwards.bsky.social · 27/05/2025
The United States has levied sanctions on Harvard but not on Russia. A curious set of values.
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Aled Edwards S.G. @aledmedwards.bsky.social · 08/05/2025
Waiting for Trump to emerge
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Reposted by Aled Edwards S.G.
Matthieu Schapira @mattschap.bsky.social · 05/05/2025
@thesgc.bsky.social is generating large/open screening data and inviting data scientists to train their ML models via DREAM challenges: 1- train your model on DEL data 2- retrospectively predict 138 ASMS true positives 3- predict new hits. We will test them and publish together. bit.ly/3YXVKoT
bit.ly
First DREAM Target 2035 Drug Discovery Challenge
'First DREAM Target 2035 Drug Discovery Challenge' (Synapse ID: syn65660836) is a project on Synapse. Synapse is a platform for supporting scientific collaborations centered around shared biomedic...
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Reposted by Aled Edwards S.G.
Ravi Menon @northernthrux.bsky.social · 05/05/2025
Congratulations @tridentpct.bsky.social open science lead Dr. Richard Gold, Faculty of Law, McGill University for being named a Distinguished James McGill Professor. Learn more about Richard here. www.mcgill.ca/law/profs/go...
mcgill.ca
Richard Gold
Full Professor Director, Centre for Intellectual Property Policy James McGill Professor Associate member, Dept of Human Genetics Chancellor Day Hall 3644 Peel Street Room 34 Montreal, Quebec Canada H3...
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Aled Edwards S.G. @aledmedwards.bsky.social · 25/04/2025
Santos sentenced to 7 years. His big mistake was not to storm the Capitol. www.cbc.ca/news/world/u...
cbc.ca
George Santos, U.S. congressman for less than a year, sentenced to more than 7 years in prison | CBC News
Disgraced former U.S. Congress member George Santos, who lied about his life story and defrauded donors, was sentenced Friday to more than seven years in prison, sobbing as he heard his punishment.
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Aled Edwards S.G. @aledmedwards.bsky.social · 25/04/2025
To me, among the most distressing things in Canadian politics is the tacit acceptance of rude and uncouth words in signs and flags directed at (almost always left-leaning) politicians. I have no idea how this became acceptable.
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Reposted by Aled Edwards S.G.
Rolling Stone @rollingstone.com · 21/04/2025
A new study models the impact of the implosion of U.S.-funded disease treatment and prevention in the developing world — and suggests that Elon Musk and Marco Rubio will go down as among history’s greatest monsters if funding and effective administration are not restored.
rollingstone.com
Count the Dead by the Millions
From HIV and tuberculosis infections to millions of dead children, the deadly impact of Rubio, Musk and Trump’s agenda has been quantified.
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Aled Edwards S.G. @aledmedwards.bsky.social · 21/04/2025
20 years ago, we retrofitted our house in downtown Toronto to be heated by closed-loop geothermal, after E had seen it being used in a home in a Swiss mountain village (for 10 years prior to that!). Works great. www.cbc.ca/newsinteract...
cbc.ca
Heat seeking
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Aled Edwards S.G. @aledmedwards.bsky.social · 19/04/2025
Fun things one might not expect to see while cycling through downtown Toronto parks.
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Aled Edwards S.G. @aledmedwards.bsky.social · 19/04/2025
I can’t say I’m a fan of the politics of blame and faux rage. It may work to get elected (sometimes), but at the expense of our society and civil discourse, as other countries have shown. www.cbc.ca/news/politic...
cbc.ca
Rebel News owner Ezra Levant was 'mentor' to Poilievre, says author | CBC News
Conservative Leader Pierre Poilievre has historic ties to Rebel News owner Ezra Levant, the right-wing media personality at the epicentre of a controversy that has engulfed Canada's Leaders' Debates Commission.
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Aled Edwards S.G. @aledmedwards.bsky.social · 18/04/2025
Watching the Canadian federal leaders debate. One candidate often starts his sentences with “The reality is….” And when that happens, you know what’s coming out of his mouth next is not.
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Reposted by Aled Edwards S.G.
Stephen O'Rahilly @stephenorahilly.bsky.social · 17/04/2025
Indeed. And so ironic that while the new administration says it is very keen to understand the effects of food on health, their actions are resulting in the closure of one the US’s most effective labs in that area @kevinh-phd.bsky.social
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Reposted by Aled Edwards S.G.
Ben Ross @benross.bsky.social · 16/04/2025
Steve Kerr wore a Harvard basketball shirt after the Warriors’ win tonight: “Yes, this is me supporting Harvard. Way to go. Way to stand up to the bully.”
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Reposted by Aled Edwards S.G.
Barack Obama @barackobama.bsky.social · 15/04/2025
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.
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Aled Edwards S.G. @aledmedwards.bsky.social · 12/04/2025
When I play make-believe with my 4 year granddaughter, she just makes up the story as she goes. She’s practicing for when she is President. www.bbc.com/news/article...
bbc.com
Trump exempts smartphones and computers from new tariffs - BBC News
The move comes after concerns that tech prices could skyrocket, as many gadgets are made in China.
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Aled Edwards S.G. @aledmedwards.bsky.social · 12/04/2025
Gotta admit that I think this warning on some CBC stories is exactly the wrong message - if our goal as Canadians is to tackle complex problems together. “Warning: This story includes discussion of offensive and racist language.”
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Aled Edwards S.G. @aledmedwards.bsky.social · 11/04/2025
“Data collection and coordination are expensive, so governments and firms will need to step up to fund them. Given the payoffs…..the investments are well worth the costs.” www.science.org/doi/10.1126/...
science.org
AI drug development’s data problem
The future of drug discovery may be artificial intelligence (AI), but its present is not. AI is in its infancy in the field. To help AI mature, developers need nonproprietary, open, large, high-qualit...
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Aled Edwards S.G. @aledmedwards.bsky.social · 11/04/2025
I just retrieved all the emails I received from one Program Officer at NIA. Of 119 emails over 6 years, 18 were sent in evening, before 7AM or on weekend. The dedication to the public good shown by NIH staff is amazing. www.nytimes.com/2025/04/11/o...
nytimes.com
Opinion | The Nihilistic, Chaotic Year So Far at the N.I.H.
Efficiency is not being enhanced, nor is waste being eliminated at the N.I.H. Scientists are just left to wonder: Why?
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Reposted by Aled Edwards S.G.
Princess Margaret Cancer Centre @pmresearch-uhn.bsky.social · 11/04/2025
Congratulations to our Senior Scientist Dr. Daniel De Carvalho for receiving the 2025 Peter Gilgan Canada Gairdner Momentum Award! 🎉 Read the media release here: www.gairdner.org/resource-hub...
gairdner.org
2025 Canada Gairdner Award Winners Announced
2025 Canada Gairdner Awards recognize world-renowned scientists for transformative contributions to research impacting human health
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Aled Edwards S.G. @aledmedwards.bsky.social · 11/04/2025
C’mon @cbcnews-rss.bsky.social editors. You just manufactured a lead story based on 2 folks’ spouting non-evidence based opinions, complete with talk of conspiracy. What public interest does this serve? www.cbc.ca/news/politic...
cbc.ca
Some Conservative supporters question whether the polls can be trusted | CBC News
CBC’s Poll Tracker shows the Conservatives trail the Liberals by nearly seven points nationally, but some Pierre Poilievre supporters say they don't believe it.
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Aled Edwards S.G. @aledmedwards.bsky.social · 10/04/2025
David Brooks sees Idiocracy in America’s future. And present.
nytimes.com
Opinion | The Stupidity of the Tariffs Are the Achievement of a Lifetime
Maybe we’re just not good at thinking anymore.
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Aled Edwards S.G. @aledmedwards.bsky.social · 10/04/2025
C’mon @nytimes.com. Would you write a column entitled “Trump claims he saw Sasquatch”…and then devote four more paragraphs on what colour it might be? The 75 countries are fantasy and should not be reported til confirmed independently. www.nytimes.com/2025/04/10/u...
nytimes.com
Trump, Offering Few Details, Insists ‘Everybody’ Wants to Make a Deal With the U.S.
The administration says foreign governments are racing to the United States to negotiate, but exactly which countries might strike a deal — and over what — remains unclear.
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Reposted by Aled Edwards S.G.
E. Richard Gold @richardgold.bsky.social · 10/04/2025
Robert Cook-Deegan and me in @science.org: AI drug development’s data problem: www.science.org/doi/10.1126/...
science.org
AI drug development’s data problem
The future of drug discovery may be artificial intelligence (AI), but its present is not. AI is in its infancy in the field. To help AI mature, developers need nonproprietary, open, large, high-qualit...
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Aled Edwards S.G. @aledmedwards.bsky.social · 10/04/2025
Kathleen Clark, law prof, on potential market manipulation yesterday by Trump who said “buy now!” and then hours later dropped tariffs. “If we still had a rule of law, a robust system for the rule of law, it would be investigated,”
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Aled Edwards S.G. @aledmedwards.bsky.social · 09/04/2025
One way to think about the financial situation is that “it will pass” when there’s a new US election. But the Americans who knowingly voted for a felon/fraudster haven’t gone away. And a Congress afraid of its own shadow won’t either. I honestly don’t see how the US comes back from this.
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