Most advanced triple-negative breast cancers remain resistant to immunotherapy. Here, the authors discover that RIPK1-driven necroptosis in both tumor and stromal compartments is essential for effecti...

View details and apply for this Scientific Operations Project Manager vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and experience. Future p...

Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.

View details and apply for this Postdoctoral Training Fellow - Functional Genomics vacancy in Chelsea . Salary: £45,600 - £49,350 p.a. inclusive dependent o n relevant Postdoctoral...

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Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...

In a recent issue of Cell, Arribas et al. and Pasquesi et al. explore the phenomenon of transposable element (TE) exonization and its impact on proteomic and immune diversity, highlighting its potential role as a driver of evolutionary innovation.

Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferropto...

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

Mechanisms dictating the form of chemotherapy-induced cancer cell death are elusive. This study reports that immunologically cold triple-negative breast cancer (TNBC) hijacks an ancient ER stress resp...

View details and apply for this Head of Biology and Director, Centre for Target Validation (Group Leader) vacancy in Sutton. Competitive Starting Salary Tenure : Appointments will be mad...

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Apoptosis, necroptosis and pro-inflammatory NF-κB-dependent signaling are repressed by receptor-interacting serine/threonine-protein kinase 1 (RIPK1). A recent paper in Immunity describes a small m...

Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...