Reposted by Rune Busk Damgaard
🚨New preprint!🚨
Lack of specific affinity reagents hinders studies of signalling mechanisms. We show that sdAbs provide a robust scaffold for making linkage-specific ubiquitin binders, exemplified by 2A6, a versatile reagent for M1-linked ubiquitin chains.
www.biorxiv.org/content/10.6...
