iiinova — where your digital self keeps evolving

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Reese Richardson @reeserichardson.bsky.social · 25/08/2026

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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IMPRS for Genome Science @imprsgs.bsky.social · 26/06/2026

Special thanks to our guests for the inspiring talks and the fantastic interaction @maiwen-ch.bsky.social @tschwammle.bsky.social and Salma Balazadeh! Your insights added so much value to our retreat. And to Hanna Sänger for the vital talk on mental health during the PhD! 🧠✨ #ScienceRetreat #PhDLife

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Wolfgang Huber @wkhuber.bsky.social · 17/01/2026

For many years, Peer Bork organised Bio-IT retreats to bring together the bioinformaticians across EMBL, in Garmisch-Partenkirchen and later Feldberg. Days out on the mountain followed by forward-looking and meta-science oriented sessions in the hut that fueled many projects and careers.

Peer Bork on top of Zugspitze, ready to race down

Peer Bork, Jan Korbel, others at Sonnenkar ski lift at Zugspitze

Après-Ski scientific sessions from 16:00 till very late.

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Jörg Vogel @jorg-vogel-lab.bsky.social · 12/12/2025

Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs. www.helmholtz-hiri.de/fileadmin/HI...

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Nikolai Slavov @slavov-n.bsky.social · 30/11/2025

The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts. We have been mapping mRNA modifications for over a decade. => Characterizing their functions -- especially on translation -- is a research frontier.

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Harmit Singh Malik @harmitmalik.bsky.social · 07/11/2025

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

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Philip Ball @philipcball.bsky.social · 05/09/2025

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA. www.cell.com/cell/fulltex...

cell.com

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biolog...

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John Lees @johnlees.bacpop.org · 15/08/2025

My PhD student @leonielorenz.bsky.social (with Eva Geissen) has made this nice (free) online course to introduce mathematical modelling for biology: www.ebi.ac.uk/training/onl... Including both molecular and epidemiological examples

ebi.ac.uk

Mathematical modelling for biologists - Modelling concepts in biological research

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Ralf Jansen @ralfjansen.bsky.social · 02/08/2025

My colleagues Baptise Rafanel et al. investigated how a newly invading transposon can be silenced. They found that not only antisense insertions in piRNA clusters such as flamenco, but also insertions in the 3‘UTR of genes can drive potent silencing.

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Mitch Guttman @mitchguttman.bsky.social · 26/07/2025

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

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Simon Fisher @profsimonfisher.bsky.social · 28/07/2025

Not sure who came up with "Manhattan Plot", but in 2014 I coined the alternative term "Nijmegen Plot" (inspired by the Dutch town where I live) to describe underwhelming results from our earliest genome-wide association scans of language/reading traits.

Contrasting photographs of the night-time skylines of Manhattan (left) and Nijmegen (right), with matching genome-wide association plots underneath each.

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H. Courtney Hodges @hodgeshc.bsky.social · 22/07/2025

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions. www.cell.com/molecular-ce...

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Jay Brito Querido @jbquerido.bsky.social · 22/07/2025

Finally out! I’m thrilled to share our new paper (Wolin et al., Cell 2025). This paper describes SPIDR, a high-throughput method for mapping RBP binding sites. By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.

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Saloni @scientificdiscovery.dev · 21/07/2025

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

ebi.ac.uk

AlphaFold - A practical guide

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Rita Strack @ritastrack.bsky.social · 07/07/2025

Opportunity alert!

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Dave Shechner @shechnerlab.bsky.social · 30/06/2025

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit! tinyurl.com/ydn6e3ac

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Journal of Cell Biology @jcb.org · 28/05/2025

Structure of the microtubule anchoring factor NEDD1 bound to the γ-tubulin ring complex. new study from Hugo Muñoz-Hernández, Yixin Xu, Michal Wieczorek @mike-wieczorek.bsky.socia @ethz.ch and colleagues: rupress.org/jcb/article/... #Cytoskeleton #StructuralBiology #CryoEM

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John Schneekloth (Jay) @jschneek.bsky.social · 28/05/2025

Out now in @natchem.nature.com! Lots to unpack here, but in short - we show that SMM enabled fragment based design is useful on RNAs to improve chemical properties like affinity and brightness of fluorophore ligands. www.nature.com/articles/s41...

nature.com

Structure-informed design of an ultrabright RNA-activated fluorophore - Nature Chemistry

Fluorogenic RNA aptamers such as Mango are powerful tools for RNA imaging. An ultrabright RNA-activated fluorophore with improved photophysical performance has now been developed using a structure-inf...

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Coskun Lipid Cellar @ ZML Dresden @lipid.bsky.social · 09/05/2025

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

science.org

Measurements of molecular size and shape on a chip

Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...

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Reposted by Maïwen Caudron-Herger

Itai Yanai @itaiyanai.bsky.social · 28/04/2025

Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.

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Flora Vincent @floravincent.bsky.social · 14/04/2025

#EMBOClimateResilience “The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems” @embo.org @monicabettencourt.bsky.social

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Isabella Graf @isabellagraf.bsky.social · 24/03/2025

We are organizing a conference for young researchers at the intersection between physics & biology: www.embl.org/about/info/c... @embl.org @events.embl.org @intcha.bsky.social Please consider applying/registering -- the deadline is already in one week!

embl.org

Interdisciplinary challenges in the physics of complexity and life 2025 (IntCha25)

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Maria Leptin @marialep.bsky.social · 11/03/2025

Today all 27 EU countries endorsed the Warsaw Declaration. Thank you for your solid support in calling for the independence of the European Research Council to be preserved and for the role of the ERC to be expanded. polish-presidency.consilium.europa.eu/media/r5fa13... 🇪🇺

polish-presidency.consilium.europa.eu

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Richard Sever @richardsever.bsky.social · 11/03/2025

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

openrxiv.org

Homepage - openRxiv

openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.

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Maïwen Caudron-Herger @maiwen-ch.bsky.social · 10/03/2025

Our study on the #riboregulation of key mitotic factors is now published in Nature Communications www.nature.com/articles/s41... Additional findings include: - RNA stimulates AURKA kinase activity - RNA stabilises AURKA conformation #RNA #RNAsky #mitosis #spindle

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kinesinmotors.bsky.social @kinesinmotors.bsky.social · 09/03/2025

🧪 Open position: Scientific Grant Writer

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CNRS @cnrs.fr · 06/03/2025

#Communiqué 🗞️ Le CNRS exprime sa solidarité avec les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd'hui mise à l’épreuve. 👉 www.cnrs.fr/fr/presse/le...

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Sträßer lab @straesserlab.bsky.social · 28/02/2025

Interested in RNA biology, especially mRNA processing and export from nucleus to cytoplasm? We are looking for an enthusiastic PhD student to investigate the RNA-binding proteins Sub2 and Tho1 🧪🧫🔬 More details and instructions on how to apply: www.uni-giessen.de/de/ueber-uns...

uni-giessen.de

Doctoral student (m/f/d) in the field of RNA Biology

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Austin E. Y. T. Lefebvre @austin-lefebvre.bsky.social · 27/02/2025

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

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Teif lab @teiflab.bsky.social · 20/02/2025

Thank you very much, Bowel Cancer UK, for funding our work! This is a joint project with Ralf Zwacka, Andrea Mohr and Greg Brooke, devoted to nucleosomics of cfDNA in colorectal cancer. Please forward this to relevant candidates for a postdoc on this project! generegulation.org/job-opening/

generegulation.org

Postdoc opportunity: nucleosome repositioning in cancer (bioinformatics, genomics) – Gene Regulation – Teif Lab

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Maïwen Caudron-Herger @maiwen-ch.bsky.social · 18/02/2025

Within the @hlsalliance.bsky.social Interinstitutional Postdoctoral Call #PostDocCalls in Heidelberg, Ulrike Engel and myself are looking for a posdoc interested in the RNA dependence of microtubule regulators. See project #55 of the call (option A) www.health-life-sciences.de/opportunitie...

Image adapted from Marx et al. MBoC 2013.
F-actin in green and microtubules in red

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Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · 14/02/2025

This week we had International Day of Women and Girls in Science 👩‍🔬 🥼 🔬 There are many women working to provided the resources at PDBe, AlphaFoldDB, EMDB and EMPIAR. Lets met a few of them! #IDWGS #WomeninSTEM #WomenInScience #WhatAScientistLooksLike

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Cytoskeleton Journal @cytoskeljournal.bsky.social · 17/02/2025

Check out one of our latest "Pictures of the Month" in #CYTOSKELETON #microscopymonday onlinelibrary.wiley.com/doi/full/10....

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Jörg Enderlein @joergenderlein.bsky.social · 13/02/2025

The German Research Council (DFG) has just announced drastic funding cuts—a deeply concerning development in times of growing hostility toward science and global crises. The DFG is not to blame; rather, it is the result of Germany’s self-destructive austerity policies. www.dfg.de/de/aktuelles...

dfg.de

Infolge von Inflationsentwicklung und Kostensteigerungen: DFG ergreift Maßnahmen zur Ausgabenstabilisierung

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Health + Life Science Alliance Heidelberg Mannheim @hlsalliance.bsky.social · 10/02/2025

Here is an exciting opportunity from the IMSEAM - Selhuber-Unkel Group for a Masters Program at Universität Heidelberg. Next info sessions are February 11 and 19. More information on the website: lnkd.in/esbENqeJ Hashtag#IMSEAM Hashtag#UniHeidelbergIMSEAM Hashtag#UniHeidelberg Hashtag#MasterMSSE

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Winkler Laboratory @winklerlab.bsky.social · 07/02/2025

📢 Es ist 5 vor 12❗ "Aufstehen für Demokratie" setzt sich für faktenbasierte politische Entscheidungen und Demokratie ein: www.aufstehenfuerdemokratie.de www.openpetition.de/!ychtb 📅 Sei dabei am 12.02 um 11:55 Uhr an Hochschulen und Forschungseinrichtungen 🔬 Wissenschaft braucht Demokratie 🤝

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 06/02/2025

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC

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Maximilian Madern @maxmadern.bsky.social · 03/02/2025

Our paper is out! We delevoped a method to follow individual translating ribosomes for hours in living cells, and discovered that ribosomes are great friends and help each other in problematic situations: www.cell.com/cell/fulltex...

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Olga Afonso @olgaafonso.bsky.social · 03/02/2025

New paper alert! ‼️‼️ Super happy to share that my postdoc paper is finally out! 1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.

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Whitehead Institute @whiteheadinstitute.bsky.social · 03/02/2025

Looking for activities that are both fun and educational for K-12 students? BioNook curates free, online ways for kids (and parents) to learn about science and the world of biology research. wi.mit.edu/bionook

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Elisabeth Bik @elisabethbik.bsky.social · 27/01/2025

‘Stamp out paper mills’ — science sleuths on how to fight fake research By Anna Abalkina, René Aquarius, Elisabeth Bik, David Bimler, Dorothy Bishop, Jennifer Byrne, Guillaume Cabanac, Adam Day, Cyril Labbé & Nick Wise @nature.com www.nature.com/articles/d41...

nature.com

‘Stamp out paper mills’ — science sleuths on how to fight fake research

A group of scientists who are experts at spotting fraudulent research outline five essential steps to combat industrialized scientific misconduct.

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