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H. Courtney Hodges

@hodgeshc.bsky.social
380 followers 223 following 12 posts

Baylor College of Medicine

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Reposted by H. Courtney Hodges
From the Labs at Baylor College of Medicine @bcmfromthelabs.bsky.social · 30/07/2025
Drs. HC Hodges @hodgeshc.bsky.social, #chanyuensan, K Cermakova @cermakova.bsky.social et al discovered a molecular bridge that facilitates interactions among disordered proteins involved in regulating #geneExpression. #BetaCatenin @bcmhouston.bsky.social #MolecularCell blogs.bcm.edu/2025/07/24/f...
blogs.bcm.edu
A molecular bridge helps disordered proteins work properly
The findings reveal that despite their disordered nature, the protein interactions that drive gene expression are surprisingly modular and even have an underlying organization.
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H. Courtney Hodges @hodgeshc.bsky.social · 22/07/2025
How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions. www.cell.com/molecular-ce...
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H. Courtney Hodges @hodgeshc.bsky.social · 27/11/2023
What do SWI/SNF-addicted cancers have in common? And when are they most sensitive to SWI/SNF inhibition? Check out Katka’s thread highlighting our most recent paper
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Reposted by H. Courtney Hodges
Alex Holehouse @alexholehouse.bsky.social · 13/11/2023
A labor of love - our review on why IDRs matter for cellular function is live in Nat. Rev. Mol. Cell. Biol: www.nature.com/articles/s41... Working with Birthe Kraglund on this was such a pleasure, and we hope this review will be helpful to a broad audience!
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