Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

I’m excited to run my first half marathon around the track at Silverstone. I am doing this to support Race Against Dementia, a charity that holds special significance for me and which began with Sir J...

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, finds a new…

Parkinson's disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late...

In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…

The first ever treatment for the rare neurodegenerative disease Friedreich’s ataxia – for which UCL and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out

The amyloid precursor protein (APP) is processed by multiple enzymes to generate biologically active peptides, including amyloid-β (Aβ), which aggregates to form the hallmark pathology of Alzheimers d...

The amyloid precursor protein (APP) is processed by multiple enzymes to generate biologically active peptides, including amyloid-β (Aβ), which aggregates to form the hallmark pathology of Alzheimers d...

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...

While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

The University of Liverpool is seeking a Postdoctoral Research Associate to explore The Role of the Astrocytic Endosomal System in Health and Disease.

In this TEDx talk, Prof Tara Spires-Jones will describe how neuroscience research is helping defeat dementia. Dementia is one of the biggest medical and soci...

Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

Nature Communications - Deep learning enhanced chemical imaging delineated polymorphic Aβ plaques in situ. Cored plaques were associated with increased Aβ1-40 and 3pE-42 deposition. A...

YouTube video by UK Dementia Research Institute - UK DRI

Induced pluripotent stem cell (iPSC) models are powerful tools for neurodegenerative disease modelling, as they allow mechanistic studies in a human genetic environment and they can be differentiated ...