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Come funziona il Premio Il Premio “I Protagonisti dell’Innovazione 2026” nasce con l’obiettivo di valorizzare professionisti, organizzazioni e startup che, nel corso del 2025, si sono distinti per la ...

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Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

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Multiple sclerosis (MS) is a chronic neurological disease characterized by nerve damage and consequent impairments in vision, movement, balance and mental function.

Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells share cross-reactivity and pathogenic features with T cell responses to EBNA1 from Epstein-Barr virus, and their activation worsens MS-like disease in mice.

This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy…

This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...

Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

Cangkrama et al. show that tumor cells from various cancer types use the mitochondrial trafficking protein MIRO2 and nanotubes to transfer mitochondria into surrounding fibroblasts, thereby inducing c...

Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticis...

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters a...

Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts. They show that i

Mitochondrial dysfunction is involved in several disease states, mitochondria transfer and transplantation have the potential to address this. Here, the authors review recent advancements and cha...

Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

Cell Death & Differentiation - Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression

The brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details diff...

This study identifies a unique multiple sclerosis lesion, the broad rim lesion, which is associated with rapid disease progression and marked by a distinct inflammatory profile involving innate inflam...

Cao et al. demonstrate excitatory neuronal tropism of the AAV capsid AAV-MG1.2 that was initially proposed for targeting microglia in the mouse brain. AAV-MG1.2 shows great promise for expanding our g...

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

There has been a recent expansion in our understanding of DNA-sensing mechanisms. Mitochondrial dysfunction, oxidative and proteostatic stresses, instability and impaired disposal of nucleoids cause t...

Die Jung-Stiftung für Wissenschaft und Forschung fördert humanmedizinische Spitzenforschung durch Preise in einem Gesamtvolumen von derzeitig 540.000 Euro pro Jahr. Damit gehören die Preise zu den Höc...