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Fran Quintana Lab

@quintanalabhms.bsky.social
185 followers 114 following 3 posts

Our goal is to combine advanced tools with innovative experimental models to study neuroinflammatory disorders and cancer. Tweets by lab members. quintanalab.bwh.harvard.edu

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Fran Quintana Lab @quintanalabhms.bsky.social · 05/08/2026
Our new study, led by Joon-Hyuk Lee, is out today in @nature.com! We discovered a population of CD40+MHC-II+ astrocytes that present antigens to CD4+ T cells, enhancing pathogenic Th17 responses and promoting CNS autoimmunity. www.nature.com/articles/s41...
nature.com
Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity - Nature
Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoi...
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Fran Quintana Lab @quintanalabhms.bsky.social · 25/06/2025
Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in ‪@nature.com today! Congrats to Brian Andersen and Camilo Faust Akl! www.nature.com/articles/s41...
nature.com
Barcoded viral tracing identifies immunosuppressive astrocyte–glioma interactions - Nature
Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...
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Fran Quintana Lab @quintanalabhms.bsky.social · 11/06/2025
New pre-print from our lab here: www.biorxiv.org/content/10.1...
biorxiv.org
Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples
We recently described astrocyte pro-inflammatory epigenetic memory based on multiple complementary in vivo and in vitro studies, and the analysis of multiple sclerosis samples. Based on bioinformatic ...
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