Our new study, led by Joon-Hyuk Lee, is out today in @nature.com! We discovered a population of CD40+MHC-II+ astrocytes that present antigens to CD4+ T cells, enhancing pathogenic Th17 responses and promoting CNS autoimmunity.
www.nature.com/articles/s41...
nature.com
Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity - Nature
Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoi...