With its Proof of Concept (PoC) grants, the European Research Council (ERC) supports scientists in further developing the economic potential of their research results. Two scientists from the German C...

In this Review, Golebiewska and colleagues summarize the main features of the immunosuppressive microenvironment in glioblastoma (GBM) and discuss how different therapeutic approaches reshape GBM immu...

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.

Conference

This is the research team DKFZ Deutsches Krebsforschungszentrum Helmholtz-Gemeinschaft Universität Heidelberg Universitätsmedizin Mannheim Neurooncology Heidelberg Health + Life Science Alliance I hav...

Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...

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Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

Universität Heidelberg bietet Stelle als Full Professorship (W3) in Molecular Biology (f/m/d) with a Focus on Biological Engineering in Heidelberg - jetzt bewerben!

Nature - We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion,...

Nature Cancer - Wu et al. perform single-cell analyses to explore the switch from low-grade to high-grade isocitrate-dehydrogenase-mutant glioma and show that it is characterized by oligodendrocyte...