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Reposted by @chopralab.bsky.social

Department of Chemistry, Stanford University @stanfordchemistry.bsky.social · 04/11/2025

Joining us from Purdue, Prof. Gaurav Chopra will be giving a Chemical Biology Seminar on "How do Glial and Immune Cells become Dysfunctional in Aging and Neurodegeneration?" today at 3PM in STLC 114. chemistry.stanford.edu/events/chemi...

chemistry.stanford.edu

Chemical Biology Seminar: Professor Gaurav Chopra, Purdue University | Chemistry

About the Seminar"How do Glial and Immune Cells become Dysfunctional in Aging and Neurodegeneration?"Pathogenic aging leads to neurodegeneration and imposes chronic metabolic stress on the brain, rewi...

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chopralab.bsky.social @chopralab.bsky.social · 31/05/2025

🚨 Catch the MIND Lab at #ASMS2025! Our trainees present cutting-edge work on AI-agents, lipidomics, & neurodegeneration in talks & posters all week. From AI-agents to single-cell FA profiling to PROTAC proteomics—don’t miss it!🧠#AIagents #Neuroimmunology #Lipidomics @asms.org

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chopralab.bsky.social @chopralab.bsky.social · 21/05/2025

Our Immunity @cp-immunity.bsky.social Cover was not selected but nothing can hold back the Microglia super-heroine when she has DGAT2-blocking beverage. #NotTheCover Read the full article in Immunity: www.cell.com/immunity/ful...

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Reposted by @chopralab.bsky.social

Dimitrios Davalos & Lab @davalos.bsky.social · 21/05/2025

Microglia: A super-heroine that had a DGAT2-blocking beverage (cans) so she could break the chains from lipid droplets holding her back (LD weights) and lift the amyloid load (beams) that trapped the neurons, thereby rescuing them in the aged Brain (City sign)! #NotTheCover @cp-immunity.bsky.social

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Reposted by @chopralab.bsky.social

Dimitrios Davalos & Lab @davalos.bsky.social · 19/05/2025

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...

cell.com

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

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