As a clinician scientist at the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University, neurologist Lukas Bunse is investigating how the body's own immune syste...

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...