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Leonard Frach

@leofrach.bsky.social
237 followers 276 following 29 posts

Postdoc in psychiatric genetics and clinical psychologist at University Hospital Bonn | PhD @ucl.ac.uk | Within-family analyses, statistical genetics, polygenic scores, behaviour genetics, epigenetics | he/him

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Reposted by Leonard Frach
Silvia Paracchini @silparacchini.bsky.social · 08/09/2026
🚨PhD opportunity for health professionals: We are offering a PhD project investigating the impact multimorbidity impact of neurodevelopmental conditions along the life course 🙏Please share 🙏 www.gla.ac.uk/postgraduate...
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Lisa DeBruine @debruine.bsky.social · 11/08/2026
The following R script downloads your public projects from the OSF. Set the variable "me" to your OSF user ID, which you can find at osf.io/profile after logging in.
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Leonard Frach @leofrach.bsky.social · 30/07/2026
One of my hardest and longest PhD challenges is coming to a close (well, almost). Very happy to finally share the preprint to our updated Gsens method! Major updates include the extension to multiple exposure scenarios, along with using raw data, estimating mediation effects and many more.
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Leonard Frach @leofrach.bsky.social · 30/07/2026
One of my hardest and longest PhD challenges is coming to a close (well, almost). Very happy to finally share the preprint to our updated Gsens method! Major updates include the extension to multiple exposure scenarios, along with using raw data, estimating mediation effects and many more.
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medRxivpreprint @medrxivpreprint.bsky.social · 17/07/2026
Genetic sensitivity analysis: estimating genetic confounding and environmentally mediated genetic effects using multiple exposures www.medrxiv.org/content/10.64898/20…
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Adam Rutherford @adamrutherford.bsky.social · 17/07/2026
It took 11 minutes to change my driver's licence on the DVLA website, and so far, 94 minutes to CANCEL my Virgin broadband account.
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Dirk Pelt @dirkpelt.bsky.social · 15/07/2026
🆕 New pre-print! osf.io/preprints/ps... Are you satisfied with your life because you are satisfied with your friends, health, job, etc.? Or is it actually the other way around: are some people generally satisfied with their life and, because of this, satisfied with their friends, health, job, etc.?
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Leonard Frach @leofrach.bsky.social · 08/07/2026
Excited to share our new review article on polygenic scores in psychiatric research and clinical practice! www.degruyterbrill.com/document/doi... with @davifri.bsky.social, Markus Nöthen & Andreas Forstner
degruyterbrill.com
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Leonard Frach @leofrach.bsky.social · 08/07/2026
Excited to share our new review article on polygenic scores in psychiatric research and clinical practice! www.degruyterbrill.com/document/doi... with @davifri.bsky.social, Markus Nöthen & Andreas Forstner
degruyterbrill.com
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Eiko Fried @eikofried.bsky.social · 11/06/2026
Been saying this for years: Don't submit to Frontiers. Don't peer-review for Frontiers. It's long been considered a predatory publisher by many in the field, including many who have worked as editor there.
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Daniel Lakens @lakens.bsky.social · 27/05/2026
Excellent news! Nature is expanding Registered Reports to all the fields in which they publish! A great result by all those proposing this strong solution to publication bias and selective reporting (and getting expert feedback before data collection)! www.nature.com/articles/d41...
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Perline Demange @perlinedemange.bsky.social · 14/05/2026
This paper fills me with joy and hope. After a muted response to the ethical challenges facing the field (e.g., embryo selection), juniors are the ones stepping up. Thank you to the PhD candidates who wrote this commentary calling this out and offering solutions. www.nature.com/articles/s41...
nature.com
Early-career-researcher-led best practices for social science and behavioural genetics - Nature Human Behaviour
An emerging market promotes embryo selection for behavioural traits including IQ, but the response of the social and behavioural genetic research community remains muted. We call for unified best prac...
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Miri Forbes @miriforbes.bsky.social · 06/05/2026
Are we still posting our raw datasets now that they're being farmed for genAI-written papers? I'm starting to feel differently now sharing data before I'm totally done with my own research questions...
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Abdel Abdellaoui @dr-appie.bsky.social · 24/03/2026
Me & @aysuo.bsky.social are hiring a postdoc to study gene–environment interplay in health & social inequalities 🧬 You'll analyze genomic data as part of a collaboration with Uppsala & Oslo at @amsterdamumc.bsky.social (NL) werkenbij.amsterdamumc.org/en/vacatures... Please RT for karma points ♥️
werkenbij.amsterdamumc.org
Vacatures - Postdoctoral researcher specialising in gene–environment interplay - Amsterdam UMC
Ready to unravel the complex interplay between genes and environment shaping health and society? Join our interdisciplinary team analyzing large-scale genomic data across Europe. Are you eager to contribute to groundbreaking research on health and social inequalities?
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Tim Morris @timtmorris.bsky.social · 02/03/2026
🚨We have a fully-funded PhD scholarship (UCL/Birkbeck) starting October 2026 to look at how genetic, family, and social factors shape children’s language and literacy development. **Deadline 29th March**. Further details at bit.ly/40B2Wrx, please do get in touch if you are interested!
bit.ly
Untangling genetic and environmental pathways to language and reading development: Integrating social and genetic data from longitudinal cohort studies
Principal Supervisor: Dr Tim Morris (UCL) Co-Supervisors: Dr Emma Meaburn (Birkbeck); Professor Bonamy Oliver (UCL) Project Description Language and reading skills are key drivers of educational su…
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Leonard Frach @leofrach.bsky.social · 26/02/2026
We have a new preprint online describing the molecular genetic and epigenetic data in the German TwinLife Study (TwinSNPs and TECS samples). Together with shared first authors @charlottepahnke.bsky.social & @aliciaschowe.bsky.social More detailed thread coming soon! www.biorxiv.org/content/10.6...
biorxiv.org
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Leonard Frach @leofrach.bsky.social · 26/02/2026
We have a new preprint online describing the molecular genetic and epigenetic data in the German TwinLife Study (TwinSNPs and TECS samples). Together with shared first authors @charlottepahnke.bsky.social & @aliciaschowe.bsky.social More detailed thread coming soon! www.biorxiv.org/content/10.6...
biorxiv.org
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Kerstin Ludwig @kuludwig.bsky.social · 19/02/2026
🖨️ Hot off the press 🍾 : I am super excited to share that our article on the host control of persistent EBV infection has just been published in Nature Magazine, in an accelerated article preview version: rdcu.be/e4Lg8
rdcu.be
Host control of persistent Epstein–Barr virus infection
Nature - Host control of persistent Epstein–Barr virus infection
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David Howard @usedforglue.bsky.social · 18/02/2026
Just posted a new preprint! We uncovered reproducible symptom‑based subtypes of depression. Findings include: • melancholic, atypical & psychomotor subtypes • links between insomnia + weight gain clusters and asthma • psychomotor clusters associated with Parkinson’s disease 🔗 doi.org/10.64898/202...
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Eivind Ystrom @eivindy.bsky.social · 05/02/2026
I'm hiring #PROMENTA @uio.no: Researcher (PhD) in post-pandemic youth mental health (#NordForsk consortium SISU/PRISM). #MoBa #genetics + registry data -> gene-environment interactions. Please share! www.jobbnorge.no/en/available... @ki.se @haskolinn.bsky.social @thlorg.bsky.social
jobbnorge.no
Researcher in Post-Pandemic Youth Mental Health  (294258) | University of Oslo
Job title: Researcher in Post-Pandemic Youth Mental Health  (294258), Employer: University of Oslo, Deadline: Thursday, March 5, 2026
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Eivind Ystrom @eivindy.bsky.social · 04/02/2026
Article alert!🚨 1/11 Parents matter - and we can quantify part of that influence genetically. Our new JCPP paper on multivariate indirect maternal genetic effects across internalizing and externalizing symptoms. doi.org/10.1111/jcpp... #jcpp @uio.no @unioslo-svfak.bsky.social @unioslo-uv.bsky.social
doi.org
<em>Journal of Child Psychology and Psychiatry</em> | ACAMH Pediatric Journal | Wiley Online Library
Background From a functionalist perspective, parenting behaviors have adaptive functions and are partly expressions of genetic variation. Maternal genes that have effects on children are often refer...
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rogier kievit @rogierk.bsky.social · 18/12/2025
I've used Lavaan almost every (work)day for 15 years, but this open source labour of love has never received proper institutional support. I'm delighted to be a small part of an 1.5M OpenScienceNL award, led by Jorgensen, to completely revamp and futureproof Lavaan www.openscience.nl/en/news/45-p...
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
nature.com
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...
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Björn E. Hommel @bjoernhommel.bsky.social · 26/11/2025
🚨 SynthNet is out 🚨 Researchers propose new constructs and measures faster than anyone can track. We (@anniria.bsky.social @ruben.the100.ci) built a search engine to check what already exists and help identify redundancies; indexing 74,000 scales from ~31,500 instruments in APA PsycTests. 🧵1/3
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Rosa Cheesman @rosacheesman.bsky.social · 04/11/2025
1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...
nature.com
Genetic associations with educational fields - Nature Genetics
Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...
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Behavior Genetics Association @behaviorgenetic.bsky.social · 28/10/2025
We currently have multiple job openings (post-doc/assistant prof/associate prof) listed on our website, see thread below if you don't want to miss out! bga.org/content.aspx...
bga.org
BGA Job Listings - Behavior Genetics Association
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Laurel Raffington @laraffington.bsky.social · 28/10/2025
We have an open postdoc position in Social Science Genomics in Berlin! Includes gene-environment interplay within German population cohorts & experimental online survey studies to probe public perceptions of potential DNA biomarker applications 🔗 www.mpib-berlin.mpg.de/2196134/2025...
mpib-berlin.mpg.de
Postdoctoral Position in Social Science Genomics | Max Planck Research Group Biosocial
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Leonard Frach @leofrach.bsky.social · 10/10/2025
Looking for an *amazing* postdoc supervisor? 👀 Excellent opportunity with the one and only @jessiebaldwin.bsky.social
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Jessie Baldwin @jessiebaldwin.bsky.social · 10/10/2025
I'm hiring! ✨ Looking for a Research Fellow to study environmental factors that mitigate intergenerational transmission of mental health. 3-year post at UCL @uclbrainscience.bsky.social with great opportunities for training, collaboration & exciting science! 🔗 Apply: www.jobs.ac.uk/job/DOZ633/r...
jobs.ac.uk
Research Fellow in Mental Health at UCL
Apply for the Research Fellow in Mental Health role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Amanda J. Wright @ajwright.bsky.social · 05/09/2025
New paper out at the Journal of Psychopathology and Clinical Science! We examined unconditional & event-related changes in pathological vs normal-range personality using 4 metrics to compare their developmental links, how these vary with life events, and whether unique effects emerge across metrics
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Ted Schwaba @tedmond.bsky.social · 02/09/2025
I'm looking for a PhD student to do some trailblazing at the frontier of personality genomics and lifespan gene-environment transactions (start Fall 2026)! If you want to work with me: psychology.msu.edu/graduatestud... (PS @drmeltemyucel.bsky.social is taking a student too, in moral psych/dev!)
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Maurizio Sicorello @msicorello.bsky.social · 19/08/2025
BIG PREPRINT🔬 In a newly founded consortium we show that we barely know anything about the neurobiology underlying emotion regulation capacity! (40 fmri samples, N=2175) So, time-out for prefrontal cortex explanations! And we also show why this might be the case 🧵 www.biorxiv.org/content/10.1...
biorxiv.org
The elusive neural signature of emotion regulation capabilities: evidence from a large-scale consortium
Cognitive reappraisal is a fundamental emotion regulation strategy for mental and physical well-being, but how its neural mechanisms relate to individual differences remains poorly understood. In a co...
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Fabian Streit @fstreit.bsky.social · 13/08/2025
An updated preprint of our Borderline Personality Disorder GWAS is now online: www.medrxiv.org/content/10.1...
medrxiv.org
Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders
We conducted the largest genome-wide meta-analysis of borderline personality disorder (BPD) to date, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 case...
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Robin Hofmeister @rjhfmstr.bsky.social · 06/08/2025
🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!
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Margot van de Weijer @margotvdweijer.bsky.social · 01/08/2025
New pre-print online: Imputing parental genotypes through Mendelian Imputation: Ethical and Legal Considerations osf.io/preprints/ps...
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Leonard Frach @leofrach.bsky.social · 24/07/2025
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team! Check out Kerstin's thread for overview
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Leonard Frach @leofrach.bsky.social · 24/07/2025
Very exciting preprint by @axel-schmidt.bsky.social, @kuludwig.bsky.social and team! Check out Kerstin's thread for overview
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jennyvandongen.bsky.social @jennyvandongen.bsky.social · 23/07/2025
New preprint by Xiaopu Zhang! www.biorxiv.org/content/10.1... @jordanatbell.bsky.social @ntrbiopsy.bsky.social
biorxiv.org
Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects
Background Genetic variants that are associated with phenotypic variability, or variance quantitative trait loci (vQTLs), have been detected for multiple human traits. Gene-environment interactions ca...
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Kerstin Ludwig @kuludwig.bsky.social · 22/07/2025
🔔Paper alert! Extremely excited to share a preprint from our lab! Spearheaded by @axel-schmidt.bsky.social, a super talented medical & computational geneticist, we studied latent Epstein-Barr virus (EBV) infection at population-scale. Interested in how this works & what we found? Read along! 👇
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Sophie Breunig @breunigsophie.bsky.social · 21/07/2025
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
nature.com
Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry
Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders
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Tina Kretschmer @doctinak.bsky.social · 10/07/2025
PhD position in my group at @fau.de, as part of my @erc.europa.eu Consolidator project PAR2. German is not essential but an interest in social science genetics would be great! Sharing would be much appreciated ❤️ www.jobs.fau.de/jobs/phd-pos...
jobs.fau.de
PHD Position at the Department of Developmental and Educational Psychology (m/f/d)
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Tabea Schoeler @tabeasch.bsky.social · 08/07/2025
🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇
shorturl.at
Design and model choices shape inference of age-varying genetic effects on complex traits
Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...
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Adriaan @adriaan-vd-graaf.bsky.social · 04/07/2025
Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...
A network of metabolites and their potential causal relationships. Green edges are Detected by the statistical causal inference method MR-link-2
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Olivia Wootton @olivia-wootton.bsky.social · 03/07/2025
New preprint!🚨 "“The Contribution of Common and Rare Genetic Variation to Emotional and Behavioural Symptoms in Childhood and Adolescence” is out on medRxiv. www.medrxiv.org/content/10.1... Thread 👇
medrxiv.org
The Contribution of Common and Rare Genetic Variation to Emotional and Behavioural Symptoms in Childhood and Adolescence
Genetic factors influence vulnerability to common mental health conditions, but their role in early-life mental health remains understudied. We analysed genotype array and exome sequence data from two...
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Senator Bernie Sanders @sanders.senate.gov · 24/06/2025
While the world watches Israel's war with Iran, Netanyahu's extremist government continues to starve and massacre Palestinians in Gaza. Today, Israeli forces again opened fire on people desperately trying to collect food aid, killing dozens. Over 56,000 have been killed so far.
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medRxivpreprint @medrxivpreprint.bsky.social · 18/06/2025
Intergenerational Transmission of Parental Mental Health and Wellbeing Traits on Offspring Emotional and Behavioural Difficulties www.medrxiv.org/content/10.1101/202…
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Neil Davies @neilmdavies.bsky.social · 18/06/2025
Looking for your next research position? We're recruiting two genetic epidemiologists to work on two projects at the Division of Psychiatry at UCL, part of the growing UCL Human Genomics group.
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Chris Rayner @chrisrayner.bsky.social · 16/06/2025
Thanks @eivindy.bsky.social! My first foray into the mysterious world of #SelectionBias. Very happy to receive feedback, and to discuss opportunities for improving/expanding this work!
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Eivind Ystrom @eivindy.bsky.social · 13/06/2025
🧵 THREAD: Preprint from @chrisrayner.bsky.social reveals how to fix selection bias in the Norwegian #MoBa study using population-wide registry data! For the first time, we can quantify and adjust for selection bias in this major epidemiological resource. Spread the good news! osf.io/preprints/os...
osf.io
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