iiinova — where your digital self keeps evolving

Reposted by Sophie Breunig

Omid V. Ebrahimi @omidvebrahimi.bsky.social · 17/09/2026

📜 Out now: ‘Towards a genetics of mental disorders as complex dynamical systems’ After 2 years of work with @michelnivard.bsky.social & @ludvigdb.bsky.social We outline a roadmap to align behavioural genetics with novel dynamic theories of mental disorders A thread 🧵 doi.org/10.31234/osf...

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Reposted by Sophie Breunig

Luca Sclisizzo @luca-sclisizzo.bsky.social · 14/09/2026

🚨 New Preprint out! What if psychosis is not a single, homogeneous construct? "Parsing the functional heterogeneity of psychosis spectrum" addresses this question defining a genetic gradient across the spectrum. 🧬 www.medrxiv.org/content/10.6...

medrxiv.org

Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling

Schizophrenia, bipolar disorder, and major depression vary in their age of onset, cognitive impacts, degree of impairment, and clinical course. However, since psychosis is a transdiagnostic feature th...

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Reposted by Sophie Breunig

medRxivpreprint @medrxivpreprint.bsky.social · 13/07/2026

Population-scale molecular reconstruction of human circadian phase from blood biomarkers www.medrxiv.org/content/10.64898/20…

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Reposted by Sophie Breunig

Joni Coleman @jonicoleman.bsky.social · 24/06/2026

Back at #BGA2026, in the symposium "Untangling the Web", examining the genetic relationship between psychiatric disorders. Sophie Breunig introducing the symposium and talking first about Prioritizing Modifiable Risk Factors for Psychiatric Disorders via Genomic Structural Equation Modeling

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Reposted by Sophie Breunig

Stephen Turner @stephenturner.us · 09/06/2026

Pleiotropic shared heritability quantifies the shared genetic variance of common diseases www.nature.com/articles/s41... 🧬💻🧪

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Reposted by Sophie Breunig

Lydia Rader @lydiarader.bsky.social · 12/05/2026

New paper! 🎶🎸 • Do adolescents who engage in music use less substances later in development? • Are the links direct effects or due to shared genetic/environmental influences? • Is music constructive for youth at high genetic risk for substance use? Paper link: www.researchgate.net/publication/...

researchgate.net

(PDF) Adolescent Music Engagement Is Associated With Less Alcohol Consumption and Substance Experimentation 5–11 Years Later: A Genetically Informative Study

PDF | Objective: Adolescence is a critical developmental window for shaping substance use trajectories. Music engagement during this period may reduce... | Find, read and cite all the research you nee...

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Sophie Breunig @breunigsophie.bsky.social · 08/05/2026

New preprint alert! 🚨 Building on exciting new work in autism subtyping, we investigated how biological sex 👭 and age at diagnosis 👵 shape the genetic landscape of autism. 🧬 Check out our findings below 🧵 and the full paper here: www.researchsquare.com/article/rs-9...

researchsquare.com

Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a significant male prevalence bias. While recent evidence suggests that genetic heterogeneity is indexed by age at diagnosis, males...

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Sophie Breunig @breunigsophie.bsky.social · 01/05/2026

This is really awesome! As someone who grew up in this exact area, taking hikes along the former Limes, and now working in genetics, this is such a cool collision of my worlds! 🏺🧬 Are there any layperson summaries of this? I know a whole community of people who would love to learn more about this!

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Reposted by Sophie Breunig

Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 10/04/2026

New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬 www.nature.com/articles/s41...

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Reposted by Sophie Breunig

Lydia Rader @lydiarader.bsky.social · 20/03/2026

Check out our new paper! We found general chronic pain is genetically linked to broad addiction liability, while musculoskeletal pain shows more substance-specific genetic associations, particularly with tobacco and alcohol use. Link: onlinelibrary.wiley.com/share/author...

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Reposted by Sophie Breunig

Abdel Abdellaoui @dr-appie.bsky.social · 10/03/2026

If you're looking to build or deepen your knowledge in statistical genetics, the ISG Workshop (June 1–11) covers the full range: biometrics, GWAS, polygenic scores, causal inference, and more. Open to all levels, virtual, and international: www.colorado.edu/ibg/workshop... Retweets appreciated 🙏

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Sophie Breunig @breunigsophie.bsky.social · 04/03/2026

New preprint from our lab, led by the Bluesky-less Jeremy Lawrence!

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Reposted by Sophie Breunig

Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

nature.com

Mapping the genetic landscape across 14 psychiatric disorders - Nature

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...

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Reposted by Sophie Breunig

Dirk Wulff @dirkwulff.bsky.social · 23/10/2025

🚨 New publication: How to improve conceptual clarity in psychological science? Thrilled to see this article with @ruimata.bsky.social out. We discuss how LLMs can be leveraged to map, clarify, and generate psychological measures and constructs. Open access article: doi.org/10.1177/0963...

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Reposted by Sophie Breunig

medRxivpreprint @medrxivpreprint.bsky.social · 20/10/2025

Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders www.medrxiv.org/content/10.1101/202…

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Reposted by Sophie Breunig

Andrea Ganna @andganna.bsky.social · 16/10/2025

🎉 New preprint out! "Removing genetic effects on plasma proteins enhances their utility as disease biomarkers" We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease 👉 doi.org/10.1101/2025...

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Sophie Breunig @breunigsophie.bsky.social · 21/07/2025

Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...

nature.com

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry

Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

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Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 21/07/2025

Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...

nature.com

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry

Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

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Reposted by Sophie Breunig

Aoxing Liu @aoxing2.bsky.social · 25/04/2025

Type 1 diabetes (T1D) and other autoimmune diseases often co-occur in families. Leveraging data from 12.6K genotyped trios in @finngen.bsky.social, our work - online today in Cell Genomics - studied the transmission of parental autoimmune diseases on T1D in offspring. www.cell.com/cell-genomic...

cell.com

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms

Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

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Reposted by Sophie Breunig

medRxivpreprint @medrxivpreprint.bsky.social · 06/02/2025

Integrating HiTOP and RDoC Frameworks Part II: Shared and Distinct Biological Mechanisms of Externalizing and Internalizing Psychopathology www.medrxiv.org/content/10.1101/202…

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Andrew Grotzinger @andrewgrotzinger.bsky.social · 28/01/2025

One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!

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Reposted by Sophie Breunig

Michel Nivard @michelnivard.bsky.social · 28/11/2024

🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.

github.com

GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.

A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics

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Reposted by Sophie Breunig

Andrew Grotzinger @andrewgrotzinger.bsky.social · 06/12/2024

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...

medrxiv.org

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

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Reposted by Sophie Breunig

Eric Turkheimer @ent3c.bsky.social · 31/10/2024

With @kph3k.bsky.social (Paige Harden) I have a comment on an execrable paper by Rindermann et al, about the IQs of recent immigrants to Germany. Blog post and link to article below. More to come. ericturkheimer.substack.com/p/immigratio... journalofcontroversialideas.org/article/4/2/...

journalofcontroversialideas.org

Controversy Requires Competence: Comment on Rindermann et al. (2024)

Rindermann, Klauk, and Thompson (2024) purport to give evidence regarding the determinants of intelligence test scores among refugees who have immigrated to Germany from different countries of origin,...

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Laura Helmuth @laurahelmuth.bsky.social · 01/10/2024

As an editor, I help people say what they mean--and not say what they don’t mean. Here are some common not-quite-right words or expressions that I often see. This is not to embarrass anybody--I've made many of these mistakes myself. Please share your favorite fixes at the end of the thread. (1/n)

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Georg Henning @georghenning.bsky.social · 20/09/2024

I’ve seen the best minds of my generation ruined by Wissenschaftszeitvertragsgesetz

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Sophie Breunig @breunigsophie.bsky.social · 15/08/2024

New preprint just dropped! 🧬🦠 For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases. Check out the full paper here: www.medrxiv.org/content/10.1...

medrxiv.org

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

medRxiv - The Preprint Server for Health Sciences

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Reposted by Sophie Breunig

Michel Nivard @michelnivard.bsky.social · 04/12/2023

On 4th- 8th March 2024 we’ll organize the International Statistical Genetics (ISG) in Boulder, Colorado. There are still some spots open and there is financial aid available for those who meet certain criteria: www.colorado.edu/ibg/workshop

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