iiinova — where your digital self keeps evolving

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American Society of Human Genetics (ASHG) @geneticssociety.bsky.social · 17/02/2026

@ajhgnews.bsky.social sat with @adriaan-vd-graaf.bsky.social in the latest "Inside AJHG" to discuss his recently published paper, “Mendelian randomization linking metabolites with enzymes reveals pathway regulation and therapeutic avenues.”➡️ bit.ly/46di69J #ASHG #HumanGenetics

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Robert Warmerdam @robertwarmerdam.bsky.social · 06/02/2026

🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

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Adriaan @adriaan-vd-graaf.bsky.social · 05/02/2026

Mendelian Randomization is powerful but often debated. We benchmarked it against the "ground truth" of human metabolic pathways to see how often it gets it right. 🧬 Result: MR is robust! It matches known metabolism in 43% of cases and identifies valid drug targets. www.cell.com/ajhg/fulltex...

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Adriaan @adriaan-vd-graaf.bsky.social · 04/11/2025

EMGM 2026 will be in beautiful Davos this year! emgm2026.sciencesconf.org?lang=en Registration abstract submission and travel grant applications are open! Hope to see you there!

emgm2026.sciencesconf.org

54th European Mathematical Genetics Meeting - Sciencesconf.org

54th European Mathematical Genetics Meeting

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Adriaan @adriaan-vd-graaf.bsky.social · 14/10/2025

Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research! @samuelmoix.bsky.social @rjhfmstr.bsky.social

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Chris Wallace @chr1sw.bsky.social · 04/08/2025

Tip for presentations: avoid saying "I don't think this audience needs an introduction to X". Try instead giving a v brief introduction tailored to the key points you will reference in the rest of the talk. So often people assume I have knowledge I don't, and this hurts my ability to follow.

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Adriaan @adriaan-vd-graaf.bsky.social · 18/08/2025

Using google gemini with grounding for later reference? Make sure you download your links before they expire... :(

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Robin Hofmeister @rjhfmstr.bsky.social · 06/08/2025

🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!

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katja heuer @k4tj4.bsky.social · 27/07/2025

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

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Nicholas Mancuso @nmancuso.bsky.social · 21/07/2025

Super excited to see this out. What started as some math in a grant in 2020, to a student deciding to take this on in 2022, to published in 2025. These things can take time and patience is key!

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Sasha Gusev @sashagusevposts.bsky.social · 12/07/2025

I wrote a little bit about a cool recent paper looking at heritability estimates from very large registry data, and how we still really don't understand why outcomes track in families. A short 🧵:

theinfinitesimal.substack.com

We still do not understand family resemblance

...

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Tabea Schoeler @tabeasch.bsky.social · 08/07/2025

🚨New preprint is out! How do genetic effects on complex traits change with age? In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw. shorturl.at/17snd A thread 🧵👇

shorturl.at

Design and model choices shape inference of age-varying genetic effects on complex traits

Understanding how genetic influences on complex traits change with age is a fundamental question in genetic epidemiology. Both cross-sectional (between-subject) and longitudinal (within-subject) appro...

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Adriaan @adriaan-vd-graaf.bsky.social · 04/07/2025

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! www.nature.com/articles/s41...

A network of metabolites and their potential causal relationships. Green edges are Detected by the statistical causal inference method MR-link-2

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Tabea Schoeler @tabeasch.bsky.social · 19/05/2025

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! Here, we used simulation work + longitudinal GWAS and downstream analyses to explore risks involved in cognitive/physical decline (1/)🧵🧵 shorturl.at/99gqL

shorturl.at

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline - Nature Communications

Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied on cross-sectional data. With the release of longitudinally curated aging phenotypes by the UK Bioban...

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Dr. Lucky Tran @luckytran.com · 28/04/2025

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

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Kaur Alasoo @kauralasoo.bsky.social · 13/04/2025

We've just posted an updated version of our metabolic trait GWAS preprint. The GWAS summary statistics are still the same as in October, but we've included several new follow-up analyses and completely rewritten the manuscript! See thread below for some highlights. www.medrxiv.org/content/10.1...

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Anthony Herzig @anthony-herzig.bsky.social · 02/02/2025

EMGM2025 abstract deadline extended – 09/02 (final). Conference 8-9 April, Brest, France. Everything statistical and population genetics, genetic epidemiology, bioinformatics… Invited speakers: Céline Bon, Beatriz Cuyabano, Garrett Hellenthal. emgm2025.sciencesconf.org

emgm2025.sciencesconf.org

53rd European Mathematical Genetics Meeting - Sciencesconf.org

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Robin Hofmeister @rjhfmstr.bsky.social · 06/12/2024

🚨 Our preprint on parent-of-origin effects (POEs) is out! With our novel method, we inferred the parental origin of alleles for >220,000 individuals, uncovering novel insights into genetics, evolution, and health. 👉 Read here: www.medrxiv.org/content/10.1... 👇 Highlights below!

medrxiv.org

Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals

Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...

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Luke Pilling @lcpilling.bsky.social · 03/12/2024

So many awesome tools for complex trait genetics! 🧬 Great idea @michelnivard.bsky.social to create a repository listing them. I am learning about new ones every day at the moment, as people add to the repo Add yours! 🤩 github.com/MichelNivard...

github.com

GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.

A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics

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Jason Buenrostro @jbuenrostro.bsky.social · 19/11/2024

Hey, a question for the genetics community. Does genetic fine-mapping work well? How often does it miss? We usually find that most fine-mapped variants do not fall within coding or regulatory regions. Is it a limitation of epigenomics or a limitation of fine-mapping? Please share your thoughts!

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Chen-Yang Su, PhD @chenyangsu.bsky.social · 18/11/2024

🚨NEW PREPRINT! Interested in Mendelian randomization and proteomics? 🧬 We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries! Preprint: www.medrxiv.org/content/10.1... Website: broad.io/protein_mr_a...

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Adriaan @adriaan-vd-graaf.bsky.social · 21/12/2023

Wanna do pleiotropy robust MR in a single region? Introducing MR-link-2: github.com/adriaan-vd-g... Paper will be out soon, meanwhile some highlights: 1: MR-link-2 has superior AUC compared to MR and coloc methods 2: FPRs from 0.15 to 0.09 3: MR-link 2 results meaningfully deviate from other MR

github.com

GitHub - adriaan-vd-graaf/mrlink2: MR-link 2 is a summary statistics _cis_ MR method that is pleiotr...

MR-link 2 is a summary statistics _cis_ MR method that is pleiotropy robust. - GitHub - adriaan-vd-graaf/mrlink2: MR-link 2 is a summary statistics _cis_ MR method that is pleiotropy robust.

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Adriaan @adriaan-vd-graaf.bsky.social · 15/12/2023

In my work, I've been thinking about the genetic architecture of (all) human traits. Thinking of the following: Is there a way to prove that only one or two genetic variants are causal to a trait? So it's not 1000 or more snps in a region?

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