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Andrew Grotzinger

@andrewgrotzinger.bsky.social
963 followers 244 following 24 posts

Associate Professor at Memorial University interested in multivariate genomic methods development and their application to understanding shared and unique signal across human disease and risk factors. Lab website: www.p-badger-lab.com

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Andrew Grotzinger @andrewgrotzinger.bsky.social · 15/09/2026
I'm excited to announce that I just started a new position as an Associate Professor at Memorial University. I'm excited to be joining new colleagues in the North Atlantic 🇨🇦 and will be continuing my research program there in psychiatric genetics. 1/2
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Joni Coleman @jonicoleman.bsky.social · 24/06/2026
Back at #BGA2026, in the symposium "Untangling the Web", examining the genetic relationship between psychiatric disorders. Sophie Breunig introducing the symposium and talking first about Prioritizing Modifiable Risk Factors for Psychiatric Disorders via Genomic Structural Equation Modeling
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jdelafuente.bsky.social @jdelafuente.bsky.social · 05/06/2026
1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.
static.klipy.com
The Predator Emerges
ALT: The Predator Emerges
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Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 10/04/2026
Also see this write-up in CU Boulder today about the article: www.colorado.edu/today/2026/0...
colorado.edu
Mental, physical illnesses often go hand in hand. Genetic study helps explain why
An analysis of DNA from two million people shows that that the same genetic architecture that underlies things like depression, ADHD and substance abuse also
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Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 10/04/2026
New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬 www.nature.com/articles/s41...
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Abdel Abdellaoui @dr-appie.bsky.social · 10/03/2026
If you're looking to build or deepen your knowledge in statistical genetics, the ISG Workshop (June 1–11) covers the full range: biometrics, GWAS, polygenic scores, causal inference, and more. Open to all levels, virtual, and international: www.colorado.edu/ibg/workshop... Retweets appreciated 🙏
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 11/03/2026
1/5 Merola et al. (2026) and Richards et al. (2022) used genomic structural equation modelling (gSEM) to identify latent genetic constructs and explore how they map onto observed traits.
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 23/02/2026
I'm very honored to be recognized for the 2026 Janet Taylor Spence Award. ❤️ Thank you to the APS and congratulations to the other recipients this year!
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Nature @nature.com · 10/12/2025
Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3Ymtiwg
go.nature.com
Huge genetic study reveals hidden links between psychiatric conditions
Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants.
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Nature @nature.com · 12/12/2025
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed? go.nature.com/48AooC4
go.nature.com
Shared genetic risk in psychiatric disorders
Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025
Want to echo Abdel and encourage reading this excellent commentary he put together!
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Abdel Abdellaoui @dr-appie.bsky.social · 10/12/2025
For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025
1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...
nature.com
Mapping the genetic landscape across 14 psychiatric disorders - Nature
Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...
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Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 02/12/2025
IBG is saying a fond farewell to former postdoc @isyfoote.bsky.social. Isy was an invaluable asset to the institute in her time here. She is a Wellcome Trust Fellow and new faculty Queen Mary University of London. We can't wait to see what comes next for this exceptionally bright scholar 🧠🧬!
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 02/12/2025
I'm delighted to say that, as of yesterday, Dr. Isy Foote @isyfoote.bsky.social is now my former postdoc as she is staring a faculty position at Queen Mary University of London. Isy is starting the position with a Wellcome Trust Fellowship 🏆. I couldn't be prouder and she will be sorely missed! ❤️
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Sophie Breunig @breunigsophie.bsky.social · 20/10/2025
Our new preprint is out: "Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders"! 🧬🦠 www.medrxiv.org/content/10.1...
medrxiv.org
Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders
This study explored the genetic links between 11 immune-mediated diseases and 13 psychiatric disorders, addressing the limited understanding of what links these illnesses. Utilizing genomic structural...
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Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 29/09/2025
University of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...
jobs.colorado.edu
Assistant Professor
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Tiffany Ito @tiffanyito.bsky.social · 22/09/2025
University of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!! jobs.colorado.edu/jobs/JobDeta... #socialpsychology #cogpsyc #PsychSciSky #PsychJob #psycjobs #psychology 1/n
jobs.colorado.edu
Assistant Professor
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 06/08/2025
Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!
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The Polygenic Score Catalog @pgscatalog.bsky.social · 06/08/2025
Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!
pgscatalog.org
PGS Catalog - Foote IF, Nat Genet (2025) (Publication)
The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly.
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Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 21/07/2025
Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...
nature.com
Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry
Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders
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Ted Schwaba @tedmond.bsky.social · 20/05/2025
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
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Ted Schwaba @tedmond.bsky.social · 07/03/2025
Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)
nature.com
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics
Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 28/01/2025
One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 06/12/2024
You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...
medrxiv.org
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
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Jackson Thorp @jgthorp.bsky.social · 06/12/2024
New preprint! www.medrxiv.org/content/10.1... We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis. @andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social
medrxiv.org
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
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Sarah Harris @saraheharris99.bsky.social · 02/12/2024
Exciting post-doc position available working on my NIH funded project "Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset". Based in the beautiful city of Edinburgh within @edinunilbc.bsky.social elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com
Postdoctoral Research Associate
The Lothian Birth Cohorts Group within the Psychology Department, School of Philosophy, Psychology and Language Sciences is seeking a PDRA on a full time, fixed term contract until 30th of June 2025 i...
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Abdel Abdellaoui @dr-appie.bsky.social · 04/10/2024
If you're not following the Behavior Genetics Association account yet (@behaviorgenetic.bsky.social), please do! 🧬🧠🤸🏽 Me and Margot van de Weijer will be running it for the time being, sharing BGA updates and summaries of interesting research from their classic journal 📜 RTs appreciated! 🙏🏽
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 23/09/2024
🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)
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medRxivpreprint @medrxivpreprint.bsky.social · 19/07/2024
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders www.medrxiv.org/content/10.1101/202…
medrxiv.org
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1
Importance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in th
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Sophie Breunig @breunigsophie.bsky.social · 15/08/2024
New preprint just dropped! 🧬🦠 For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases. Check out the full paper here: www.medrxiv.org/content/10.1...
medrxiv.org
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders
medRxiv - The Preprint Server for Health Sciences
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Andrew Grotzinger @andrewgrotzinger.bsky.social · 25/07/2024
Proud mentor moment! Three preprints recently released from the lab: 1. Postdoc Dr. Isy Foote examined the genetic architecture of frailty. Analyses reveal seven factors of frailty with unique genetic associations, clinical correlates, and biological pathways: www.medrxiv.org/content/10.1...
medrxiv.org
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modelling
medRxiv - The Preprint Server for Health Sciences
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