Andrew Grotzinger @andrewgrotzinger.bsky.social · 15/09/2026I'm excited to announce that I just started a new position as an Associate Professor at Memorial University. I'm excited to be joining new colleagues in the North Atlantic 🇨🇦 and will be continuing my research program there in psychiatric genetics. 1/2 2201
Reposted by Andrew GrotzingerJoni Coleman @jonicoleman.bsky.social · 24/06/2026Back at #BGA2026, in the symposium "Untangling the Web", examining the genetic relationship between psychiatric disorders. Sophie Breunig introducing the symposium and talking first about Prioritizing Modifiable Risk Factors for Psychiatric Disorders via Genomic Structural Equation Modeling 233
Reposted by Andrew Grotzingerjdelafuente.bsky.social @jdelafuente.bsky.social · 05/06/20261/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.static.klipy.comThe Predator EmergesALT: The Predator Emerges 13216
Reposted by Andrew Grotzinger Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 10/04/2026Also see this write-up in CU Boulder today about the article: www.colorado.edu/today/2026/0...colorado.eduMental, physical illnesses often go hand in hand. Genetic study helps explain whyAn analysis of DNA from two million people shows that that the same genetic architecture that underlies things like depression, ADHD and substance abuse also 032
Reposted by Andrew Grotzinger Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 10/04/2026New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬 www.nature.com/articles/s41... 183
Reposted by Andrew GrotzingerAbdel Abdellaoui @dr-appie.bsky.social · 10/03/2026If you're looking to build or deepen your knowledge in statistical genetics, the ISG Workshop (June 1–11) covers the full range: biometrics, GWAS, polygenic scores, causal inference, and more. Open to all levels, virtual, and international: www.colorado.edu/ibg/workshop... Retweets appreciated 🙏 02524
Reposted by Andrew GrotzingerPsychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 11/03/20261/5 Merola et al. (2026) and Richards et al. (2022) used genomic structural equation modelling (gSEM) to identify latent genetic constructs and explore how they map onto observed traits. 131
Andrew Grotzinger @andrewgrotzinger.bsky.social · 23/02/2026I'm very honored to be recognized for the 2026 Janet Taylor Spence Award. ❤️ Thank you to the APS and congratulations to the other recipients this year! 2222
Reposted by Andrew GrotzingerNature @nature.com · 10/12/2025Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3Ymtiwggo.nature.comHuge genetic study reveals hidden links between psychiatric conditionsAnalysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants. 14620
Reposted by Andrew GrotzingerNature @nature.com · 12/12/2025Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed? go.nature.com/48AooC4go.nature.comShared genetic risk in psychiatric disordersScientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed? 1348
Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/2025Want to echo Abdel and encourage reading this excellent commentary he put together! 1112
Reposted by Andrew GrotzingerAbdel Abdellaoui @dr-appie.bsky.social · 10/12/2025For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7 14016
Andrew Grotzinger @andrewgrotzinger.bsky.social · 10/12/20251/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...nature.comMapping the genetic landscape across 14 psychiatric disorders - NatureGenomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders... 212351
Reposted by Andrew Grotzinger Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 02/12/2025IBG is saying a fond farewell to former postdoc @isyfoote.bsky.social. Isy was an invaluable asset to the institute in her time here. She is a Wellcome Trust Fellow and new faculty Queen Mary University of London. We can't wait to see what comes next for this exceptionally bright scholar 🧠🧬! 071
Andrew Grotzinger @andrewgrotzinger.bsky.social · 02/12/2025I'm delighted to say that, as of yesterday, Dr. Isy Foote @isyfoote.bsky.social is now my former postdoc as she is staring a faculty position at Queen Mary University of London. Isy is starting the position with a Wellcome Trust Fellowship 🏆. I couldn't be prouder and she will be sorely missed! ❤️ 1100
Reposted by Andrew GrotzingerSophie Breunig @breunigsophie.bsky.social · 20/10/2025Our new preprint is out: "Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders"! 🧬🦠 www.medrxiv.org/content/10.1...medrxiv.orgImmune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric DisordersThis study explored the genetic links between 11 immune-mediated diseases and 13 psychiatric disorders, addressing the limited understanding of what links these illnesses. Utilizing genomic structural... 161
Reposted by Andrew Grotzinger Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 29/09/2025University of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...jobs.colorado.eduAssistant Professor 167
Reposted by Andrew GrotzingerTiffany Ito @tiffanyito.bsky.social · 22/09/2025University of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!! jobs.colorado.edu/jobs/JobDeta... #socialpsychology #cogpsyc #PsychSciSky #PsychJob #psycjobs #psychology 1/njobs.colorado.eduAssistant Professor 4110107
Andrew Grotzinger @andrewgrotzinger.bsky.social · 06/08/2025Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!! 0153
Reposted by Andrew GrotzingerThe Polygenic Score Catalog @pgscatalog.bsky.social · 06/08/2025Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!pgscatalog.orgPGS Catalog - Foote IF, Nat Genet (2025) (Publication)The Polygenic Score (PGS) Catalog is an open database of published PGS and the relevant metadata needed to apply and evaluate them correctly. 093
Reposted by Andrew Grotzinger Institute for Behavioral Genetics (IBG) @ibg.colorado.edu · 21/07/2025Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...nature.comExamining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational PsychiatryTranslational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders 094
Reposted by Andrew GrotzingerTed Schwaba @tedmond.bsky.social · 20/05/2025Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1... 515370
Reposted by Andrew GrotzingerTed Schwaba @tedmond.bsky.social · 07/03/2025Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)nature.comComparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature GeneticsGenomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric... 14719
Andrew Grotzinger @andrewgrotzinger.bsky.social · 28/01/2025One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message! 152
Andrew Grotzinger @andrewgrotzinger.bsky.social · 06/12/2024You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...medrxiv.orgGenomic network analysis characterizes genetic architecture and identifies trait-specific biologyPervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana... 42910
Reposted by Andrew GrotzingerJackson Thorp @jgthorp.bsky.social · 06/12/2024New preprint! www.medrxiv.org/content/10.1... We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis. @andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.socialmedrxiv.orgGenomic network analysis characterizes genetic architecture and identifies trait-specific biologyPervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana... 0152
Reposted by Andrew GrotzingerSarah Harris @saraheharris99.bsky.social · 02/12/2024Exciting post-doc position available working on my NIH funded project "Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset". Based in the beautiful city of Edinburgh within @edinunilbc.bsky.social elxw.fa.em3.oraclecloud.com/hcmUI/Candid...elxw.fa.em3.oraclecloud.comPostdoctoral Research AssociateThe Lothian Birth Cohorts Group within the Psychology Department, School of Philosophy, Psychology and Language Sciences is seeking a PDRA on a full time, fixed term contract until 30th of June 2025 i... 086
Reposted by Andrew GrotzingerAbdel Abdellaoui @dr-appie.bsky.social · 04/10/2024If you're not following the Behavior Genetics Association account yet (@behaviorgenetic.bsky.social), please do! 🧬🧠🤸🏽 Me and Margot van de Weijer will be running it for the time being, sharing BGA updates and summaries of interesting research from their classic journal 📜 RTs appreciated! 🙏🏽 0127
Andrew Grotzinger @andrewgrotzinger.bsky.social · 23/09/2024🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia) 11211
Reposted by Andrew GrotzingermedRxivpreprint @medrxivpreprint.bsky.social · 19/07/2024Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders www.medrxiv.org/content/10.1101/202… medrxiv.orgExamining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1 Importance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in th 033
Reposted by Andrew GrotzingerSophie Breunig @breunigsophie.bsky.social · 15/08/2024New preprint just dropped! 🧬🦠 For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases. Check out the full paper here: www.medrxiv.org/content/10.1...medrxiv.orgExamining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric DisordersmedRxiv - The Preprint Server for Health Sciences 672
Andrew Grotzinger @andrewgrotzinger.bsky.social · 25/07/2024Proud mentor moment! Three preprints recently released from the lab: 1. Postdoc Dr. Isy Foote examined the genetic architecture of frailty. Analyses reveal seven factors of frailty with unique genetic associations, clinical correlates, and biological pathways: www.medrxiv.org/content/10.1...medrxiv.orgUncovering the multivariate genetic architecture of frailty with genomic structural equation modellingmedRxiv - The Preprint Server for Health Sciences 1111