In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

Non-alcoholic liver disease (NAFLD) is now metabolic dysfunction-associated steatotic liver disease (MASLD), emphasizing the key metabolic factors of obesity, insulin resistance, vascular dysfunction and dyslipidaemia. Here, we discuss impacts on the existing body of clinical and preclinical liver disease research and on research moving forward.

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase...

Posttranslational modifications play a crucial role in regulating autophagy and lysosome–related transcription factor TFEB. Huang et al. find the increase

imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase a...

Nature Metabolism, Published online: 14 July 2025; doi:10.1038/s42255-025-01325-7Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Nature Reviews Endocrinology - Glycogen metabolism: not just a one-trick pony

Skeletal muscle is essential for movement and maintaining energy homeostasis and is the primary tissue for insulin-stimulated glucose uptake. Skeletal muscle is composed of various cell types that hel...

People living with type 1 diabetes have significantly increased cardiovascular risk compared with the general population. Traditional risk factors include hypertension, dyslipidaemia, and obesity. How...

Nature Metabolism, Published online: 01 July 2025; doi:10.1038/s42255-025-01306-wSynapses have long been thought to rely exclusively on glucose metabolism for energy. In this issue of Nature Metabolism, Kumar et al. reveal that synapses can tap into fatty acid metabolism to fuel ATP production and maintain synaptic activity when glucose is limited.

The recent identification of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous antagonist and inverse agonist of the growth hormone secretag

Slowed relaxation and altered MERCs embody early stages of aging in muscle, and are prevented by regular exercise.

With PN-477, Protagonist is directly going up against Eli Lilly, which is advancing retatrutide, also a triple-G agonist, in a Phase II trial.

The invention in this patent application relates to pyrazolo-[1,5-<i>a</i>]-pyridine derivatives represented herein as formula I and formula II. These compounds are highly active SIK inhibitors and ma...

Damage to the vascular lining leads to interactions with red blood cells that hint at how to treat dangerous complications of heart attack, stroke and COVID-19.

Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

Aims/hypothesis Previous studies reporting lower skeletal muscle mitochondrial function in type 1 diabetes did not account for cardiorespiratory fitness, a key confounder when assessing mitochondrial ...

Latency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. In this work, we describe a 617–kilo–base pairs integrated giant viral element in t...

Nature Metabolism, Published online: 29 April 2025; doi:10.1038/s42255-025-01299-6The debate over whether to agonize or antagonize GIPR signalling has divided the obesity drug design field. Studies from Gutgesell et al. and Liu et al. represent important first steps towards disentangling divergent neural networks that explain the success of both strategies for promoting weight loss.

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age-related sarcopenia, a condition characterized by muscle mass loss. Through the creation of ....

Abstract. Skeletal muscle insulin resistance (IR) is a critical deficiency in IR pathophysiology that significantly affects overall metabolic health. Skele

A small, preliminary trial and studies in mice draw links between fibromyalgia and alterations of the gut microbiome.

Nature - Geographic and age variations in mutational processes in colorectal cancer

Hexoses, including glucose, fructose, and galactose, are six-carbon monosaccharides that play fundamental roles in mammalian metabolism, with glucose serving as the primary energy source and fructose ...

The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid-transport proteins.

There is currently a global epidemic of obesity and obesity-related diseases such as type 2 diabetes due to decreased physical activity, excessive ...

Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. It is generally defined as glucose intolerance with onset

Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a...

Nature Metabolism, Published online: 07 April 2025; doi:10.1038/s42255-025-01249-2In humans, conception during cold seasons is shown to exhibit higher brown adipose tissue activity and adaptive thermogenesis, and lower body mass index and visceral fat accumulation in the offspring.

Nature Metabolism, Published online: 07 April 2025; doi:10.1038/s42255-025-01222-zParental health during conception and gestation can affect offspring development and health. A study in humans now shows that adult individuals who were conceived during cold seasons exhibit greater brown adipose tissue activity, increased energy expenditure, lower body mass index and lower visceral fat accumulation.

Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.