Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

Nature Reviews Endocrinology - Glycogen metabolism: not just a one-trick pony

Stores of glucose in the brain could play a much more significant role in the pathological degeneration of neurons than scientists realized, opening the way to new treatments for conditions like Alzhe...

Piperacillin, an FDA-approved beta-lactam, is effective at killing the Lyme disease–causing agent Borrelia burgdorferi.

Sleep is an essential component of our daily life. A mutation in human salt induced kinase 3 (hSIK3), which is critical for regulating sleep durati...

This Review discusses the impact of the gut microbiota on cancer and on cancer therapy, highlighting the importance of developing microbiota-targeting strategies to improve cancer therapy outcomes

Abstract. Skeletal muscle insulin resistance (IR) is a critical deficiency in IR pathophysiology that significantly affects overall metabolic health. Skele

Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagg...

Patients flocked to those Ozempic, Wegovy copycats when the branded drugs were in short supply, or if they didn't have insurance coverage for the treatments.

The authors use single-cell analyses to demonstrate the spatiotemporal plasticity of hepatocyte gluconeogenesis, highlighting the complexity of hepatic glucose homeostasis across states of feeding, fa...

Hexoses, including glucose, fructose, and galactose, are six-carbon monosaccharides that play fundamental roles in mammalian metabolism, with glucose serving as the primary energy source and fructose ...

“Landmark” study fingers fire-footed rope squirrel as a reservoir of fatal disease

Sleep deprivation shifts metabolic resources and deprioritizes processes that support cognition.

Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

Gut microbiota play a critical role in drug metabolism. Now, by exploring the human gut microbial metabolism of G-protein-coupled receptor (GPCR)-targeting drugs, uncommon pathways and biotransformati...

Researchers describe how they are using skills honed in the laboratory in their creative pursuits.

In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.

Nature Metabolism, Published online: 25 March 2025; doi:10.1038/s42255-025-01253-6Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs thermogenesis.

A lipid chaperone enables sensing of an essential fatty acid to drive tumor growth

Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

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Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.