iiinova — where your digital self keeps evolving

SvenssonLab @svenssonlab.bsky.social · 21/06/2025

Grateful to the American Diabetes Association @amdiabetesassn.bsky.social for the opportunity to make a short film about our lab at Stanford University. We talk about peptides and their roles in metabolic health. youtu.be/qUjYPTN09mI?... See you at ADA 2025 in Chicago

youtu.be

Decoding the Dark Peptidome – Svensson Lab, Stanford University

YouTube video by WebsEdgeMedicine

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SvenssonLab @svenssonlab.bsky.social · 05/03/2025

Today in @Nature, we share our latest paper. We developed an algorithm to predict novel peptides cleaved by proconvertases across all human tissues. Using this method, we identified BRP, a brain-derived anti-obesity peptide 🧠 www.nature.com/articles/s41...

nature.com

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature

Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...

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SvenssonLab @svenssonlab.bsky.social · 23/01/2025

Congratulations to Zeyuan for winning the travel prize! Thank you LifeMetabolism for supporting his work!

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Reposted by SvenssonLab

Sarafan ChEM-H @stanford-chemh.bsky.social · 27/12/2024

#YearInReview A new understanding of how ketosis is linked to body weight regulation: buff.ly/3ZOkoId

New research from the lab of Institute Scholar Jonathan Z. Long, led by first author María Dolores Moya Garzón, identifies a new metabolic pathway that helps explain the molecular links between ketogenic diets and body weight regulation.

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SvenssonLab @svenssonlab.bsky.social · 18/11/2024

Sharing our receng paper in Cell Systems that demonstrates how AlphaFold can predict the binding between ligands and cell surface receptors. Congrats Niels and co-authors from K.C. Garcia lab #alphafold See paper here: cell.com/cell-systems/a…

cell.com

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Reposted by SvenssonLab

Mark Andermann @markandermann.bsky.social · 16/11/2024

Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3

rdcu.be

Stochastic neuropeptide signals compete to calibrate the rate of satiation

Nature - Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic MC4R neurons, thereby...

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