Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...

Porat et al. develop cell surface ATAC-See, discovering that mitochondrial DNA is a component of the mammalian cell surface. Cell surface DNA (csDNA) on primary human and murine B cells and monocytes ...

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral...

Mechanical loading of the tibia improves survival and recovery after brain surgery in mice and pigs. This bone–brain axis is mediated by osteocyte PIEZO1, which triggers the release of neuroprotective...

Abstract. Homing endonucleases (HEs) are selfish genetic elements that drive the mobilization of their own coding sequences, often in concert with surround

Cell Death & Disease - MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease

Background Despite the growing demand for transplantation, a shortage of donor organs persists, limiting access to this lifesaving procedure. To meet the increasing demand, organs are frequently trans...

The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are i...

Elemental sulfur is an evolutionarily ancient metabolite, yet its generation, storage, and function in animals have remained unclear. We show that mammals harbor elemental sulfur in the form of its mo...

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

I have written before about how two conceptual frameworks have shaped our thinking about cell fate, Waddington's epigenetic landscape and Davidson's gene...

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Nature Communications - In search of LncDACH1 – a perceived intronic long non-coding RNA lacking fundamental genomic annotation evidence

Compartmentalisation enables cells to spatially organise essential biochemical processes. This is exemplified by the eukaryotic nucleolus, which concentrates the machinery for ribosome biogenesis. Bac...