iiinova — where your digital self keeps evolving

Reposted by Klaus Okkenhaug

Roychoudhuri Lab @roychoudhurilab.bsky.social · 04/09/2026

Delighted to share new work published in @science.org entitled 'Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species,' led by @xanwesolowski.bsky.social in the lab science.org/eprint/YQNFA...

33310

Klaus Okkenhaug @klausokken.bsky.social · 09/08/2026

A right-handed helix in the Cambridge skyline.

190

Reposted by Klaus Okkenhaug

Philippe Dehio @pdehio.bsky.social · 16/07/2026

My first post here - so let‘s start with a bang! Last week the major part of my MD-PhD work at the @biomedizin.unibas.ch was published @emboreports.org. I want to thank my supervisors and amazing collaborators for their efforts and contributions to this story. So let‘s talk about what we found!

link.springer.com

A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration - EMBO Reports

Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization of organelles within cells, including endo-lysosomes, is a prerequisite of migration. However, how ultrastructural pol...

1103

Klaus Okkenhaug @klausokken.bsky.social · 19/06/2026

Not just another kinase: I've edited a special issue on the many roles for PI3Kδ in adaptive immunity for the Journal of Immunology. Many thanks to Bart Vanhaesebroeck, Pam Schwartzberg, Elissa Deenick and colleagues for their excellent and timely contributions. academic.oup.com/jimmunol/iss...

academic.oup.com

Volume 215 Issue 5 | The Journal of Immunology | Oxford Academic

The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.

121

Klaus Okkenhaug @klausokken.bsky.social · 27/03/2026

Time to retire? www.nature.com/articles/s41... "We present The AI Scientist, which creates research ideas, writes code, runs experiments, plots and analyses data, writes the entire scientific manuscript, and performs its own peer review".

nature.com

Towards end-to-end automation of AI research - Nature

An artificial intelligence system can produce research papers with minimal human involvement, even passing the first round of peer review for the workshop of a main machine learning conference.

060

Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 16/02/2026

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field www.annualreviews.org/content/jour...

annualreviews.org

Tissue Regulatory T Cells

FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...

14614

Klaus Okkenhaug @klausokken.bsky.social · 21/10/2025

These are not a ranking lists we should be topping... royalsociety.org/-/media/poli...

royalsociety.org

030

Reposted by Klaus Okkenhaug

Roychoudhuri Lab @roychoudhurilab.bsky.social · 06/10/2025

Wonderful to see the seminal discoveries of Shimon Sakaguchi, Mary E. Brunkow & Fred Ramsdell recognised with the Nobel Prize. From Sakaguchi’s discovery of Treg cells to the identification of Foxp3, their research opened a new chapter in immunology, viewed from the prism of dominant tolerance.

0102

Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 06/10/2025

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

215572

Klaus Okkenhaug @klausokken.bsky.social · 02/10/2025

Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).

Kristoffer H Johansen presenting a talk at the Dept of Pathology, University of Cambridge.

040

Reposted by Klaus Okkenhaug

Jie Yang @jieyang437.bsky.social · 18/07/2025

We're recruiting a postdoc to join my lab at @oncology.ox.ac.uk & @oxcio.bsky.social to understand immune regulation in cancer and develop new approaches for cancer prevention and metastasis. Deadline: 11 August 2025 my.corehr.com/pls/uoxrecru... Lab info: www.oncology.ox.ac.uk/team/jie-yang

my.corehr.com

Job Details

059

Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 17/06/2025

I've been incredibly lucky to be supported by the @erc.europa.eu with a Start, Consolidator and now Advanced grant! Each of these awards enabled 'blue skies' research into the immune system, as well as resulting in direct translational impact on patients and via commercialisation. 🥰

5482

Reposted by Klaus Okkenhaug

Simon Cook @drsimoncook.bsky.social · 08/04/2025

I am delighted to see that Len Stephens, my colleague and PI3K pioneer, has been awarded the 2026 Biochemical Society Morton Lecture for outstanding contributions to lipid biochemistry! www.babraham.ac.uk/news/2025/04...

babraham.ac.uk

Dr Len Stephens awarded the Morton Lecture | Babraham Institute

2193

Reposted by Klaus Okkenhaug

Brian Ferguson @viropractor.bsky.social · 07/03/2025

Last few days to apply for this:

013

Reposted by Klaus Okkenhaug

Roychoudhuri Lab @roychoudhurilab.bsky.social · 05/03/2025

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

210445

Reposted by Klaus Okkenhaug

Babraham Institute @babrahaminst.bsky.social · 12/02/2025

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪 Latest Institute research with special guests ⤵️ www.eventbrite.co.uk/e/cellular-s...

eventbrite.co.uk

Cellular signals for health & disease

A symposium marking the contributions of Len Stephens and Phillip Hawkins

01513

Reposted by Klaus Okkenhaug

School of Biological Sciences @cambridgebiosci.bsky.social · 09/01/2025

📢 New position! We are recruiting an Associate Professor / Professor of Infection and/or Immunity to join our innovative research community! Find out more about the position and apply: buff.ly/40m1udb

099

Klaus Okkenhaug @klausokken.bsky.social · 07/01/2025

Many congratulations to Prof Ashley Moffett on this honour! This is in recognition of her long and impactful research on the genetics and immunology of maternal and foetal health, especially as related to pre-eclampsia and and the role of NK cells in the development and function of the placenta.

120

Klaus Okkenhaug @klausokken.bsky.social · 12/12/2024

I've added a PI3K starter pack. Please help me populate it by replying to this post. #PI3K #PTEN #AKT #mTOR #FOXO go.bsky.app/7p2g5eN

450

Reposted by Klaus Okkenhaug

ImmunoSketch @actuallypublished.bsky.social · 04/12/2024

A starter pack for PhD students and Postdocs in Immunology to connect 🔽 Drop a 🧬 and I'll add you to the list. Let's build the upcoming immuno community! #ImmunoSky 🧪 go.bsky.app/RABVXY4

799758

Klaus Okkenhaug @klausokken.bsky.social · 29/11/2024

Professorship in Immunity and Infection at the University of Cambridge: www.jobs.cam.ac.uk/job/49381/ Check out the cross-departmental infection and immunity theme for the grand challenges we want to address: www.bio.cam.ac.uk/research/inf... Application deadline: Jan 26th, 2025.

jobs.cam.ac.uk

Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge

Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.

071

Klaus Okkenhaug @klausokken.bsky.social · 28/11/2024

"The FDA has approved Genentech’s inavolisib (Itovebi) in combination with the CDK4/6 inhibitor palbociclib and the oestrogen-receptor antagonist fulvestrant for endocrine-resistant, PIK3CA-mutated, hormone receptor-positive, HER2-negative breast cancer." #PI3K www.nature.com/articles/d41...

nature.com

FDA approves PI3Kα inhibitor that does double duty as a degrader

Discover the world’s best science and medicine | Nature.com

041

Klaus Okkenhaug @klausokken.bsky.social · 27/11/2024

Our latest paper reveals an intriguing and essential role for the class III #PI3K VPS34 in Treg homeostasis and function. Selective deletion of VPS34 in Treg led to a scurfy-like phenotype, suggesting an essential role for VPS34 in Treg-suppression. doi.org/10.3389/fimm... #immunosky

1357

Reposted by Klaus Okkenhaug

Mariona Graupera @grauperalab.bsky.social · 23/11/2024

The freshly cooked video summarizing the Art project developed in the frame of our PIPgen MSCA DN: “PIPgenerating ART: Where Art meet Science “. A collaborative activitys between our students and the Cambridge School of Visual Performing Arts. www.youtube.com/watch?v=tQxA...

youtube.com

PIPgenerating ART: Where Art meet Science

YouTube video by PIPgen

072

Reposted by Klaus Okkenhaug

Johanna Joyce @johannajoyce.bsky.social · 23/11/2024

Both #Cancer #Research starter packs are now completely full! ~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️ I hope you'll find these useful to build our community here Pack 1: go.bsky.app/FEoaJMc Pack 2: go.bsky.app/6EcjWNA

3224388

Klaus Okkenhaug @klausokken.bsky.social · 21/11/2024

Mice and humans develop intestinal inflammation when PI3Kdelta is inhibited. Lyn Lim, Shimon Sakaguchi and colleagues provide evidence this is secondary to defects in the differentiation and maturation of pTreg:

061

Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 21/11/2024

A starter pack for staff, students and alumni from @campathology.bsky.social. Tag me if you have a connection to Cambridge Pathology and I'll add you to the list! go.bsky.app/DCiqQL1

084

Reposted by Klaus Okkenhaug

Jon Lim, FRCP PhD @drjonlim.bsky.social · 17/11/2024

💡 Inspired by others, as we grow our #AcademicSky #MedSky#ImmunoSky community here @bsky.app 🦋, thought it might be cool to have a #StarterPack for #CancerImmunology. Please join in or recommend a colleague! Hope this is useful 👇 go.bsky.app/PRdmHCP

4510237

Reposted by Klaus Okkenhaug

TRAstonDrs @castltrastondrs.medsky.network · 30/10/2024

NIAID releases alternative to BioRender, all illustrations freely available in public domain bioart.niaid.nih.gov

26361215

Klaus Okkenhaug @klausokken.bsky.social · 12/11/2024

Is anyone else having problems with Labstep? We have used it as a free electronic lab book. Recently one of my students got an email saying they are going to start charging and now I cannot log in to my personal account... The charges they propose are prohibitive...($30 per lab member per month!)

011

Klaus Okkenhaug @klausokken.bsky.social · 29/10/2024

Congratulations to Julius Baeck who successfully passed his PhD viva last week! Many thanks to Claudia Mauri and Daniel Hodson who examined his thesis and engaged in a stimulating discussion!

Julius Baeck with other lab members (Okkenvikings) celebrating successful PhD thesis defense.

041

Reposted by Klaus Okkenhaug

Rod Rahimi @rodrahimi.bsky.social · 01/10/2024

I haven't seen a starter pack of immunologists, so I created one. Apologies if I overlooked folks. #ImmunoSky 🧪⚕️ go.bsky.app/PY5tCas

148241

Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 26/01/2024

We have a new and unique position to join our lab as a Research Laboratory Technician at the University of Cambridge. Join an inclusive, international and diverse team, supportive of your personal and career development :) jobs.cam.ac.uk/job/44932/

067

Reposted by Klaus Okkenhaug

Adrian Liston @labliston.bsky.social · 14/01/2024

Interested in a postdoc in neuroimmunology at the University of Cambridge? We have a translational position open to develop gene therapy for traumatic brain injury, with potential to transition into a spin-off company, Aila Biotech. jobs.cam.ac.uk/job/44372/

178

Klaus Okkenhaug @klausokken.bsky.social · 18/12/2023

Postdoc available in Cancer Immunology! The project, funded by the MRC, will investigate how the #PI3K pathway can be manipulated to increase anti-tumour responses, particularly in the context of cancer metastasis. Deadline for applications Jan 31, 2024 www.jobs.cam.ac.uk/job/44318/

jobs.cam.ac.uk

Post-doctoral Scientist in Cancer Immunology (Fixed Term) - Job Opportunities - University of Cambri...

Post-doctoral Scientist in Cancer Immunology (Fixed Term) in the Department of Pathology at the University of Cambridge.

046