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Switch Lab

@vib-switch-lab.bsky.social
77 followers 37 following 9 posts

Researching aggregation-specific interactions in human disease

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Reposted by Switch Lab
VIB-KU Leuven Center for Neuroscience @vibneuroleuven.bsky.social · 10/03/2026
🤸‍♂️ Researchers from the @vib-switch-lab.bsky.social , co-led by Frederic Rousseau & Joost Schymkowitz, show that microglia can actively promote plaque formation in Alzheimer’s disease—challenging the long-standing view that these cells only defend the brain by clearing plaques. Published in @pnas.org
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Switch Lab @vib-switch-lab.bsky.social · 17/02/2026
#ProAgg26 is coming! Abstract submission is open - invitations to register will be sent after abstract review, making sure all selected participants can attend. All info: vibbio.tech/ProAgg26
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Reposted by Switch Lab
delladavid-lab.bsky.social @delladavid-lab.bsky.social · 04/07/2025
We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social
tinyurl.com
hireful.
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Switch Lab @vib-switch-lab.bsky.social · 16/06/2025
This weekend temperatures soared... perfect for the 4th CBD-CCB-NERF Beachvolley tournament. And here's the Switch team in action - well done to @ramonduran.bsky.social @brajabandhu.bsky.social‬ Alex, Sara, Fleur and Wouter!
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Switch Lab @vib-switch-lab.bsky.social · 12/06/2025
Last week Switchie Valeria successfully defended her PhD! Congratulations, Dr Narykina, and all our best wishes for the future. We'll miss you!
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Switch Lab @vib-switch-lab.bsky.social · 12/06/2025
Congratulations to Switchies @ramonduran.bsky.social & Gemma Martinez-Rivas on securing Post Doc funding from ‪@fwovlaanderen.bsky.social‬. Gemma's project focuses on AL amyloidosis and Ramon will look at co-translational protein folding (and more) during ageing. Wishing them much success!
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Switch Lab @vib-switch-lab.bsky.social · 27/03/2025
This promises to be a great meeting!
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Switch Lab @vib-switch-lab.bsky.social · 17/02/2025
Drug-resistant bacteria are a global threat. In our study, we reveal a new antibacterial strategy: a peptide that disrupts protein homeostasis by causing co-translational aggregation, killing a wide range of pathogenic bacteria 🦠💥. 📄 Full paper here: www.nature.com/articles/s41...
nature.com
Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism - Nature Communications
Protein biosynthesis is a major target of existing antibiotics that inhibit the efficiency or fidelity of the bacterial ribosome. Here, the authors show that a synthetic peptide displays bactericidal ...
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Switch Lab @vib-switch-lab.bsky.social · 17/02/2025
Most proteins fold co-translationally, but what if key residues aren’t available in time? Our new study introduces Native Fold Delay, a metric that links protein topology and translation rates to quantify folding delays. ⏳ Read more here www.nature.com/articles/s41...
nature.com
Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation - Nature Communications
During vectorial protein translation, native interactions are temporarily unsatisfied. Here, authors introduce “Native Fold Delay”, integrating protein topology with translation kinetics to quantify t...
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Switch Lab @vib-switch-lab.bsky.social · 09/01/2025
And another new team member :-) Welcoming Gerd Van der Hoeven to Switch, as a research technician. Our heterotypics team is at full strength!
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Switch Lab @vib-switch-lab.bsky.social · 07/01/2025
The new year starts with new Switchies :-) Very happy to welcome post doc Kevin Muwonge to our lab - Kevin joins our team working on heterotypic amyloid interactions.
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