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Reposted by Kristoffer H. Johansen

bioRxiv Immunology @biorxiv-immuno.bsky.social · 03/11/2025

Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells www.biorxiv.org/content/10.1101/202…

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Kristoffer H. Johansen @krishaurum.bsky.social · 03/10/2025

Thanks for a lovely time in Cambridge - great to see you all again. Already looking forward to next time.

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Kristoffer H. Johansen @krishaurum.bsky.social · 24/07/2025

Our paper is now out with peer review! This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved. Read about it below in Tims breakdown!

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Reposted by Kristoffer H. Johansen

Schumacher Lab @schumacher-lab.bsky.social · 02/05/2025

It's not the models, it's the data! We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models. www.biorxiv.org/content/10.1...

biorxiv.org

A functionally validated TCR-pMHC database for TCR specificity model development

Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...

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