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Department of Biomedicine🔬🧪

@biomedizin.unibas.ch
246 followers 73 following 93 posts

As a joint venture of the University of Basel and the University Hospitals Basel, the Department of Biomedicine (DBM) brings together basic and clinical scientists to advance our understanding of health and disease.

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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 29/09/2026
A new approach to anatomy teaching at the DBM: Felix Margenfeld and colleagues developed an ultrasound-guided dissection course, connecting real-time ultrasound with anatomical structures to strengthen students’ 3D understanding of the human body. 🔗 edoc.unibas.ch/entities/pub... @unibas.ch
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 24/09/2026
The fourteenth issue of our DBM Newsletter is here! Happy reading!👇🏼👇🏼👇🏼 DBM Newsletter Issue 14: issuu.com/departementb... @biomedizin.unibas.ch #Newsletter #Research #Science #Biomedicine
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 22/09/2026
Congratulations to Gregor Hutter on his appointment as Clinical Professor of Neurosurgery at @unibas.ch. At @biomedizin.unibas.ch, @hutterlab.bsky.social studies how immune cells can be harnessed against glioblastoma and develops new therapies. Congratulations, Gregor! 🎉
Professor Gregor Hutter.
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 15/09/2026
🎉Congratulations to David Bargiela on his @snsf.ch Ambizione Grant! His new project investigates how glioblastoma cells survive treatment and adapt their metabolism following immune attack – with the aim of identifying vulnerabilities that could improve responses to immunotherapies! What a success!
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 10/09/2026
🎉 Congrats to Hailey Kim and Mika Schneider, winner of the 2026 DBM Paper Prize for their study on EBV and autoreactive B cells in MS. And our Best Presentation Award goes to Dorssa Akbari! Read more: biomedizin.unibas.ch/en/newsdetai... #ResearchExcellence #DBMPaperPrize #BestPresentationAward
biomedizin.unibas.ch
Congratulations to this year’s DBM Paper Prize winners!
As every year, we celebrated the DBM Best Publication Award during our annual Summer Symposium today. This year, the award has a new name – the DBM Paper Prize – but its purpose remains the same: the ...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 09/09/2026
The 2026 DBM Summer Symposium took place on September 9. 🧬 We started with a keynote by Prof. @stephenquake.bsky.social, followed by four sessions showcasing research by our scientists. The day concluded with the DBM Paper Prize & Best Presentation Award. 🏆 #DBMSymposium2026 #TeamDBM #Science
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 08/09/2026
A new way to turn the tumor microenvironment against cancer: Researchers from Cambridge and Basel developed small molecules that make macrophages engulf cancer cells while reducing PD-L1-mediated immune suppression. Published in Cancer Research. 👇Publication link below. #CancerResearch
Green-stained macrophages engulf red-labeled cancer cells after treatment with PSEs. The red signal inside the macrophages shows that they have taken up cancer cells. (Image: Valerio Sabatino, University of Basel)
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 03/09/2026
The ISREC Foundation awarded two TANDEM grants to support collaborative cancer research involving DBM researchers. 🔬 The projects explore immune evasion in leukemia and T cell dysfunction in solid tumors. Congratulations to all the researchers involved! 👉 biomedizin.unibas.ch/en/newsdetai...
biomedizin.unibas.ch
Two TANDEM Grants by the ISREC Foundation strengthen translational cancer research at the DBM
The ISREC Foundation has awarded TANDEM Grants to two research projects involving scientists and clinicians from the Department of Biomedicine (DBM). These projects address significant challenges in c...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 03/09/2026
🏆 Two ERC Starting Grants for DBM researchers! Congratulations to Petya Apostolova and @dixon-lab.bsky.social, whose projects LIFE and NeuroCAN will explore new ways to understand and overcome cancer immune evasion. 🔗 Read more: biomedizin.unibas.ch/en/newsdetai... @erc.europa.eu @unibas.ch
biomedizin.unibas.ch
ERC Starting Grants Awarded to Two DBM Researchers
Each year, the European Research Council (ERC) awards Starting Grants to support outstanding early-career researchers in establishing ambitious and innovative research programs. We are delighted to an...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 02/09/2026
Mini-tumors help uncover new treatment options for liver cancer. Researchers led by Markus Heim and Sandro Nuciforo from @biomedizin.unibas.ch screened >1,600 compounds in patient-derived organoids and identified promising drug combinations that work across diverse tumors. 👇
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 27/08/2026
🏆 Congratulations to Prof. Judith Zaugg and Prof. Heinz Läubli, DBM research group leaders and recipients of the 2026 Dora Seif Prize for Cancer Research! A wonderful recognition of their outstanding contributions to cancer research. 👏 #CancerResearch #DoraSeifPrize #DBM @unibas.ch
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 11/08/2026
A patient's search for answers led to the discovery of a new type of immune disorder Researchers identified a mosaic mutation affecting only a specific subgroup of immune cells, opening new possibilities for precision diagnosis and targeted treatment for patients with unexplained immune disorders.
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 07/08/2026
New study from Nicole Oelgarth & the Zippelius lab at the @biomedizin.unibas.ch with Bright Peak Therapeutics: a first-in-class PD-1–targeted IL-18 immunoconjugate boosts tumor-killing T cells while limiting systemic side effects. 🧬 👉 jitc.bmj.com/content/14/7... @sitcancer.bsky.social
jitc.bmj.com
Anti-PD1-IL18 immunoconjugate promotes effector T cell-mediated antitumor immunity
Background Immune checkpoint inhibitors have revolutionized cancer therapy, yet a substantial proportion of patients exhibit primary or acquired resistance. Immunocytokines offer a strategy to enhance...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 04/08/2026
New in @jamaneurology.com: Jens Kuhle from @biomedizin.unibas.ch, @unibas.ch and @dkf.unibas.ch together with other colleagues shows that the blood biomarker GFAP is associated with progression independent of relapses in multiple sclerosis and may complement NfL. Congratulations to the team! 👏👇
Data from thousands of blood samples allowed the researchers to compare different biological processes involved in multiple sclerosis. (Photo: Kathleen Herrgott, RC2NB)
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 30/07/2026
New study led by Aikaterini Lampada from the Taylor lab @biomedizin.unibas.ch finds the septum — not just the hippocampus — makes new neurons in adult mice, triggered by both stress and the antidepressant fluoxetine. Serotonin seems to be the switch. 🧠 👉 doi.org/10.1126/sciadv.aed3625 @science.org
doi.org
Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment
Aversive experiences and antidepressant treatment stimulate neuron production in the adult septum.
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 28/07/2026
Dr. @mariuslange.bsky.social has been appointed Tenure-Track Assistant Professor of Systems Developmental Medicine. He combines computational biology & single-cell genomics to study how human tissues & organs develop, thereby advancing our understanding of early childhood development. 👇
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 21/07/2026
🧬 Precision treatment for ovarian cancer may work best before chemotherapy starts. New findings from the TuPro consortium support earlier molecular profiling. Proud to see @biomedizin.unibas.ch Francis Jacob and Viola Heinzelmann-Schwarz lead this work. 👉 www.nature.com/articles/s41...
nature.com
A tumor profiling resource for ovarian cancer: insights into chemotherapy-driven heterogeneity and personalized treatment strategy - Nature Communications
High-grade serous ovarian cancer is clinically challenging due to marked molecular heterogeneity and variable treatment response. Here, the authors demonstrate that integrated multimodal tumor profili...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 14/07/2026
🧠 Great news from the Molecular Neuroscience Lab! Professor Andreas Papassotiropoulos has been elected to the German National Academy of Sciences Leopoldina — one of the most prestigious scientific honors in the German-speaking world. Congratulations, Andreas! 🎉 biomedizin.unibas.ch/en/newsdetai...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 30/06/2026
Another ERC success for @biomedizin.unibas.ch: Judith Zaugg has been awarded an #ERCPoC Grant for HemaTrax, a project improving the prediction of blood toxicity in cancer therapy and drug development. It could support safer treatments and speed up the development of new therapies. 👍 @erc.europa.eu
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 09/06/2026
New in Science Immunology: NK cells in lung cancer retain tumour-killing potential and can be reactivated via NKG2A checkpoint blockade. Great study from the Zippelius Lab at @biomedizin.unibas.ch. 🫁 👉 www.science.org/doi/10.1126/... #LungCancer #Immunotherapy #NKCells
science.org
Cytotoxic CD39+ tumor-associated NK cells respond to NKG2A blockade in lung cancer
Multiomic analysis identifies CD39+ tumor-associated NK cells as a cytotoxic effector state in NSCLC responsive to NKG2A blockade.
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 29/05/2026
🔬 Two new studies from the Pinschewer Lab at the DBM shed new light on antiviral immunity — from Lassa fever vaccination to B cell “attrition” in chronic infection. Congratulations to the team! 👏 Nature Communications: www.nature.com/articles/s41... PNAS: www.pnas.org/doi/10.1073/...
Fluorescence microscopy of mouse spleen tissue comparing chronic infection with a virus to which adoptively transferred B cells bind with high affinity (top) versus infection with a virus bound at low affinity (bottom). Green marks the transferred B cells, red the germinal centers where B cells mature, white the surrounding B cell zone. (Dimitrova et al., PNAS 2026, Fig. 2H–I. Reproduced under CC BY licence.)
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 27/05/2026
The thirteenth issue of our DBM Newsletter is here! Happy reading!👇🏼👇🏼👇🏼 DBM Newsletter Issue 13: issuu.com/departementb... @biomedizin.unibas.ch #Newsletter #Research #Science #Biomedicine
issuu.com
DBM Newsletter No. 13
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 19/05/2026
Congratulations to Heinz Läubli on his appointment as Clinical Professor of Cellular Therapies at the @unibas.ch. Heinz has helped establish Basel as a leader in translational cancer immunotherapy and innovative cell therapies, including as CAR-T and TIL cells. biomedizin.unibas.ch/en/newsdetai...
biomedizin.unibas.ch
New professorship for Cellular Therapies (Läubli Lab)
The University Council of the University of Basel has appointed Professor Heinz Läubli as Clinical Professor of Cellular Therapies at the Faculty of Medicine.
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Reposted by Department of Biomedicine🔬🧪
Graduate Center University of Basel @grace-unibasel.bsky.social · 11/05/2026
Pitch Lab @unibas.ch, Wed May 13, 5:30–8:30 PM at the Biozentrum. Bring an early-stage idea or come as a collaborator. All faculties, all levels welcome. Food + drinks provided. One idea wins a prize + uniBIA support. Submit your idea: buff.ly/MQVphwt Come as collaborator: buff.ly/flpg40x
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 04/05/2026
Welcome on board @magda-sznurkowska.bsky.social ! We are happy to have you with us, and we wish you a great start! #Welcome2026 #TeamDBM #WelcomeOnBoard @biomedizin.unibas.ch DBM News: 🔗 biomedizin.unibas.ch/en/newsdetai...
biomedizin.unibas.ch
Welcome to the Team – Magdalena Sznurkowska Lab!
We are delighted to welcome Prof. Dr. Magdalena Sznurkowska as a new research group leader at the Department of Biomedicine, University of Basel. She will join our Department on May 1, 2026, where she...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 28/04/2026
Congratulations on this great achievement, Karen!👏
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 28/04/2026
Lifelong viral infections acquired at birth are not immunologically silent. A @biomedizin.unibas.ch & @unibas.ch study shows that Tfh-driven antibody responses partly control virus, but remain limited. Boosting CD4 T cell help may offer new therapeutic avenues. www.sciencedirect.com/science/arti...
sciencedirect.com
Perinatal infection elicits clonally restricted T follicular helper cell responses that drive antibody-mediated viral control
Perinatal infection often results in viral persistence, as observed for hepatitis B virus in humans. Commonly held concepts suggest that persistence i…
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 17/04/2026
MISEV2023 sets key guidelines for EV research. With contributions from Edveena Hanser, Diego Kyburz, & an international consortium, the paper is now one of the top ten most-cited papers in JEV (Wiley, 2024). Congratulations to everyone involved. isevjournals.onlinelibrary.wiley.com/doi/10.1002/...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 10/04/2026
📺 TV tip The ZDF documentary “plan b: A fresh start for the knee” features research from the @biomedizin.unibas.ch , @unibas.ch, on cartilage regeneration using patients’ own cells. 📅 10 April, 19:40 (ARTE) and 12 April, 15:30 (ZDF) Also available online. Link in comments. @dkf.unibas.ch
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 01/04/2026
Welcome on board @Frauke von Versen. We are happy to have you with us, and we wish you a great start! #Welcome2026 #welcometotheteam #welcomeonboard #TeamDBM @biomedizin.unibas.ch n.unibas.ch DBM News: 👉 biomedizin.unibas.ch/en/newsdetai...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 31/03/2026
Aβ and tau disrupt memory circuits in Alzheimer’s disease. New work from the @marcaurelbusche.bsky.social Lab at @biomedizin.unibas.ch .ch and @uclhresearch.bsky.social bsky.social links this to synaptic NMDA receptor hypofunction and shows recovery when both pathologies are reduced. 🔗See comments.
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 27/03/2026
@biomedizin.unibas.ch researchers identify a self-amplifying immune loop in systemic sclerosis, driven by mitochondrial DNA from platelets and neutrophils. The findings link mtDNA to lung involvement and suggest new therapeutic targets. 🔗 acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com
A Cooperative Release of Mitochondrial DNA From Platelets and Neutrophils Drives an Interferon Signature in Systemic Sclerosis
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the ro...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 24/03/2026
A hidden immune network inside the lung: @biomedizin.unibas.ch scientists reveal how T cells coordinate local defense against infection and cancer. 👉 www.sciencedirect.com/science/arti... @immunologyking.bsky.social #Immunology #LungImmunity #Tcells #ImmuneSystem #Influenza #CancerImmunology
sciencedirect.com
HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no mu…
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 20/03/2026
What if we could measure skin disease instead of just describing it? In indolent systemic mastocytosis, skin lesions are visible, but hard to quantify. A new study shows how AI + dermatology can change this 👇 www.sciencedirect.com/science/arti... #Mastocytosis #AI #Dermatology
sciencedirect.com
Avapritinib improves cutaneous involvement in patients with indolent systemic mastocytosis: Results from the randomized, phase 2, interventional PIONEER study
Indolent systemic mastocytosis (ISM), a clonal mast cell disease driven by the KIT D816V mutation, can often cause debilitating dermatologic symptoms.…
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 19/03/2026
Construction has begun on the facade of our new DBM building. It features 2039 electrochromic glass panes that darken automatically in sunlight, regulating daylight while maintaining clear views outside. 🔗Read more: biomedizin.unibas.ch/en/communica... @biomedizin.unibas.ch @unibas.ch
biomedizin.unibas.ch
New DBM Building – A Facade Reflecting Innovation
With the arrival of spring, the new building of the Department of Biomedicine (DBM) at the University of Basel is starting to take shape: the installation of its glass facade is now underway. The faca...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 10/03/2026
🔬 Science moves forward through collaboration! Researchers from @biomedizin.unibas.ch and the Department of Pharmaceutical Sciences (DPhW) came together for the DBM–DPhW Joint Meeting 2026 — a day of inspiring talks, exchange, and new connections across disciplines. 👏 #DBM #DPhW #LifeSciences
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 03/03/2026
Today, we’ve officially launched the Xenium platform at @biomedizin.unibas.ch in collaboration with @bsse.ethz.ch. 🚀 A major step forward for spatial transcriptomics in Basel! 👉 biomedizin.unibas.ch/en/communica...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 13/02/2026
On Wednesday, we hosted the symposium, “Sex & Gender Differences in Medicine & Research,” with Athena’s Journey. Sex & gender influence disease risk, symptoms & outcomes - yet they are underrepresented in research. Integrating them isn’t optional. It’s essential. #SexandGender #ClosingTheGap #IDWGS
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 11/02/2026
This year, we are celebrating the International Day of Women and Girls in Science with a behind-the-scenes video, "A Day in the Life of a PhD Student." The video highlights the importance of women's participation in STEM. 🌟 Watch & share! Video Link. vimeo.com/1163620393?f... #IDWGS #WomenInScience
vimeo.com
A Day In the Life of a PhD-Student: International Day of Women and Girls in Science 2026
This is "A Day In the Life of a PhD-Student: International Day of Women and Girls in Science 2026" by Department of Biomedicine on Vimeo, the home for…
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 05/02/2026
🎉 Fantastic news from @biomedizin.unibas.ch and @unibas.ch! Professor @marcaurelbusche.bsky.social has received the 2026 Rainwater Prize for Innovative Early-Career Scientists, awarded by the Rainwater Charitable Foundation. 🔗 biomedizin.unibas.ch/en/communica...
biomedizin.unibas.ch
Marc Aurel Busche awarded the 2026 Rainwater Prize for Innovative Early Career Scientists
Professor Marc Aurel Busche, Research Group Leader at the Department of Biomedicine (DBM), University of Basel, has been awarded the 2026 Rainwater Prize for Innovative Early Career Scientists. This i...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 30/01/2026
The 12th issue of our DBM Newsletter is here! We hope you enjoy reading it.👇🏼👇🏼👇🏼 DBM Newsletter Issue 12: issuu.com/departementb... @biomedizin.unibas.ch #Newsletter #Research #Science #Biomedicine
issuu.com
DBM Newsletter No. 12
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 23/01/2026
DBM Research Day 2026 has wrapped up! 🎉 There were great talks and lively discussions, as well as an excellent poster session showcasing emerging research across DBM. Thanks to everyone involved! See you in 2027! #DBMResearchDay #Science #TeamDBM @biomedizin.unibas.ch
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 20/01/2026
How does aggressive AML originate? A new study shows that thrombopoietin can prime EVI1+ stem cells, making them more vulnerable to KMT2A fusion–driven leukemia, published in @natcomms.nature.com from the Schwaller lab @biomedizin.unibas.ch. 👉 www.nature.com/articles/s41... #AML @unibas.ch
Wright-Giemsa stained cytospin preparations of murine long-term hematopoietic stem cells. (Image: Hugues-Étienne Châtel-Soulet, University of Basel).
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 14/01/2026
How can a common virus contribute to a rare disease? A new @cp-immunity.bsky.social study from @biomedizin.unibas.ch links EBV to early MS-like lesion formation by showing how B cells can act at the very start of the disease process. 🔗 doi.org/10.1016/j.ce... @unibas.ch #EBV #MultipleSclerosis
Confocal micrograph of the mouse brain. The myelin sheaths that wrap the the axons of neurons are shown in red. The blue cells are infected with a virus. Such infections cause immune cells to enter the brain. If these immune cells attack the myelin, autoimmune disease can result. Image by Hyein Kim (University of Basel).
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 12/01/2026
Two back-to-back BJH papers from the XPAG-ITP trial! 🎉 ETB+dexamethasone showed longer response & less rescue therapy vs dex alone in ITP. Immune profiling reveals baseline TCR clonality predicts durable remission. 🔗 onlinelibrary.wiley.com/doi/10.1111/... #ITP #Hematology #TranslationalResearch
Artistic rendering of platelets and immune cells highlighting immune dynamics in immune thrombocytopenia. Generated with AI.
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 09/01/2026
How can we tell whether an antibiotic eradicates an infection? Researchers from the @biomedizin.unibas.ch, at the @unibas.ch, present an antimicrobial single-cell microscopy-based method that measures antibiotic lethality in individual bacteria. 🔗 doi.org/10.1038/s415... @natmicrobiol.nature.com
Some bacterial pathogens play dead to dodge antibiotics. A new test watches them closely—and helps choose drugs that finish the job. (Symbolic image: Adobe Stock)
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 06/01/2026
From defense organ to tumor ally: Ovarian cancer can reprogram the omentum. Using scRNA-seq, @labfranz.bsky.social from the Ovarian Cancer Research Lab anc colleages @biomedizin.unibas.ch mapped how tumors reshape this tissue to favor metastasis. 👉 www.nature.com/articles/s41...
nature.com
Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming - Nature Communications
The omentum is the main metastatic site for ovarian cancer. Here, the authors present a human cell atlas of both benign and omentum metastatic ovarian cancer, providing insights into established metas...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 23/12/2025
As we wrap up 2025, we’re wishing you peaceful days filled with rest, joy, and good company. 🌟 Thank you for being part of our community this year. Happy Holidays and all the very best for 2026 — from all of us at the @ biomedizin.unibas.ch ! #HappyHolidays #NewYear2026 #Biomedicine #UniBasel
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 22/12/2025
A new study in which @biomedizin.unibas.ch played a key role shows how harmful antibodies form in MOGAD, a rare autoimmune central nervous system (CNS) disease. The Pröbstel Lab & its partners decoded the anti-MOG antibody "blueprint," paving the way for targeted therapies. doi.org/10.1212/NXI....
doi.org
Patient-Derived Monoclonal Myelin Oligodendrocyte Glycoprotein Autoantibodies Mediate Cytotoxicity | Neurology Neuroimmunology & Neuroinflammation
Background and ObjectivesSerum myelin oligodendrocyte glycoprotein (MOG) antibodies are a hallmark of the newly defined neuroinflammatory disease entity MOG antibody–associated disease (MOGAD). Yet, t...
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Department of Biomedicine🔬🧪 @biomedizin.unibas.ch · 18/12/2025
Collaborative research from @biomedizin.unibas.ch, @biozentrum.unibas.ch and @sib.swiss reveals that natural protein variants can block antibody drugs—meaning some therapies may fail before treatment begins! 🔗 Publication: www.science.org/doi/10.1126/...
science.org
Single–amino acid variants in target epitopes can confer resistance to antibody-based therapies
Naturally occurring genetic variants in genes encoding human target antigens can confer resistance to antibody-based therapies.
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