Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Technicolor images of tumor samples are changing cancer research.

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

Researchers are targeting dormant tumour cells that might explain why some cancers reappear long after successful treatment.

The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically impair immune function, abrogating immunotherapy response. Bone metastases led to osteopontin (OPN) production, which suppressed immunity in distal lesions. This highlights a novel cross-organ communication hindering antitumor immunity.

The site of metastatic disease influences treatment response. A recent study in Cancer Cell by Cheng et al. revealed that bone metastases systemically…

Upon pathogen detection, phagocytes trigger immunity. This process induces tissue stress and the formation of host-derived molecules that further tune immune responses. We show that host-derived oxidi...

Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

The Cancer Research Institute (CRI) proudly announces the 2025 class of Lloyd J. Old STARs—five rising scientific leaders poised to reshape cancer immunotherapy through daring, paradigm-shifting resea...

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A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.

Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

Below are the state capitals and major cities (alphabetized by state) hosting official Stand Up for Science events. If your city is listed, a confirmed site leader—backed by our core team—is active…

New group hopes to turn out researchers for 7 March demonstrations against Trump administration policies