Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...

Scientific Reports - Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data visualization research in a checkl...

Grok doubted 6 million death toll, days after peddling conspiracy theory of ‘white genocide’ in South Africa

Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice.

Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action.

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...

The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing damage to its complex nature? The answer might be foun...

Cell Death & Disease - The integrated stress response engages a cell-autonomous, ligand-independent, DR5-driven apoptosis switch

Hexanucleotide repeat expansion (HRE) in the non-coding region of the gene C9orf72 is the most prevalent mutation in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia. The C9orf72 HRE co...

In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and comment on implications for the de...

Parkinson's disease (PD) involves multiple pathological processes in midbrain dopaminergic (mDA) neurons, including protein degradation defects, vesicular trafficking disruption, endolysosomal dysfunc...

Techbio companies are using AI in numerous ways to develop new drugs; what approaches will work for neurologic and neuropsychiatric diseases?

The picornavirus Enterovirus D68 (EV-D68) is an important pathogen associated with acute flaccid myelitis (AFM). The pathogenesis of AFM involves infection of spinal motor neurons and motor neuron dea...

A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

Founder of Isomorphic Labs aims to develop a drug in oncology, cardiovascular or neurodegeneration areas

A claudin5 binding peptide enhances transport across the blood-brain barrier by transiently permeabilizing tight junctions.

Nature Neuroscience - Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and...

The FDA issued draft guidance to provide recommendations on the use of artificial intelligence intended to support a regulatory decision about a drug or biologi

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

Probes 101 – How to choose a fluorescent probe for your imaging experiment - Tools

FDA Novel Drug Approvals 2024 #medicine That is a wrap for 2024! And another year of relentless drug discovery! There you have it, drug-hunting aficionados,… | 90 comments on LinkedIn

Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.