Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...

Ksilink Notebooks. Contribute to Ksilink/Notebooks development by creating an account on GitHub.

Scientific Reports - Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

Creating clear and engaging scientific figures is crucial to communicate complex data. In this Comment, I condense principles from design, visual perception and data visualization research in a checkl...

Grok doubted 6 million death toll, days after peddling conspiracy theory of ‘white genocide’ in South Africa

Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice.

Investigated the frequency of specific words before and after 2022 in PubMed abstracts - johanneswilbertz/ChatGPT_scientific_abstracts

Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action.

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of specific cell t...

The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing damage to its complex nature? The answer might be foun...

Cell Death & Disease - The integrated stress response engages a cell-autonomous, ligand-independent, DR5-driven apoptosis switch

Hexanucleotide repeat expansion (HRE) in the non-coding region of the gene C9orf72 is the most prevalent mutation in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia. The C9orf72 HRE co...

In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and comment on implications for the de...

Parkinson's disease (PD) involves multiple pathological processes in midbrain dopaminergic (mDA) neurons, including protein degradation defects, vesicular trafficking disruption, endolysosomal dysfunc...

Techbio companies are using AI in numerous ways to develop new drugs; what approaches will work for neurologic and neuropsychiatric diseases?

The picornavirus Enterovirus D68 (EV-D68) is an important pathogen associated with acute flaccid myelitis (AFM). The pathogenesis of AFM involves infection of spinal motor neurons and motor neuron dea...

A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.