Children in Africa and South East Asia are most at risk from antibiotics medicines no longer working, a study suggests.

Some are viruses with global pandemic potential - like Covid - others infectious illnesses with no treatments.

The Food Standards Agency (FSA) is looking at how it can speed up the approval process for lab-grown foods.

The CRFT is a programmable freezing and thawing system that allows you ultimate control of cryopreservation research protocols.

Wu et al. provide new insights into how aspartame consumption exacerbates atherosclerosis through an insulin-dependent mechanism. Aspartame-triggered high insulin levels upregulate the endothelial mem...

The lead researcher has told the BBC he was so astounded he assumed his computer had been hacked.

It could be wildfires, a pandemic or a financial crisis. The super-rich will flee to their bunkers – the rest of us will have to fend for ourselves, writes columnist George Monbiot

Drugs that can prevent or relieve migraine attacks are only effective for some people. Research is starting to untangle the reasons why.

Twenty-five years ago, Viagra kick-started the second sexual revolution and a controversy unlike any drug before it. From Wales to New York, this is the big story of the little blue pill.

Humans—and analogous life beyond Earth—may represent the probable outcome of biological and planetary coevolution.

The pontiff will remain in hospital for as long as necessary, the Vatican has said.

Male-male competition strongly influences mate selection in Drosophila, with males performing wing flicks to repel their rivals and jam a female’s perception of other potential mates. Recruitment of p...

The deadly cancer is often not found until it has spread to other parts of the body.

Plastics have infiltrated every recess of the planet, including your lungs, kidneys and other sensitive organs. Scientists are scrambling to understand their effects on health.

Cefis et al. show that mitochondrial respiration and ROS production are not affected during healthy muscle aging but identify altered mitochondrial calcium handling as a potential key driving mechanis...

The findings shed light on a deeply mysterious part of Earth that is key to life on our planet.

The Big Experiment · Episode

"We had no ICUs at that time. We had no antivirals, had no vaccines for flu. We had no idea that the flu was even a virus at that time," one scholar said. But social distancing helped then too.

This perspective offers a cross-disciplinary roadmap toward synthetic life that does not shy away from technical and non-technical challenges, ethical concerns, and provocative implications, embracing...

Insights from probing the shock-absorbing layer within the crustacean’s club-like claw could inspire the design of tough new materials.

Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...

One of the most valuable substances in the world has never been replicated. Are we close?

So far, microorganisms have been research subjects or contaminants on space stations, but could they assist longer missions?

Context National vaccine recommendations in the United States target an increasing number of vaccine-preventable diseases for reduction, elimination, or eradication.Objective To compare morbidity and ...

Some scientists fear the risk of a collapse to warm Atlantic currents has not been taken seriously.

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

A DNA testing method is 90% accurate at predicting bowel cancer risk in high-risk people with IBD, according to a study by our scientists.

The technology could give patients with advanced heart failure new hope, based on early trial results.

The human genome encodes potentially thousands of tiny proteins that were previously overlooked. The search is on to find out what they do.

Three existing human infections are causing the greatest concern, but H5N1 bird flu is also worrying human and animal health experts.

H5N1 is adapting to new mammalian hosts, raising the possibility of the virus spreading between humans.

The lack of in vivo accurate human liver models hinders the investigation of liver-related diseases, injuries, and drug-related toxicity, posing challenges for both basic research and clinical applica...

In the midst of pandemic upheaval, researchers have gained fundamental insights about how the body fends off infections.

Enzyme immobilization is an efficient and cost-effective approach to recovering, stabilizing, and enhancing enzyme catalytic properties. It is a challenge, however, for coimmobilized multiple enzymes to perform consecutive reactions without being inactivated under similar conditions. Here, we present a facile enzyme immobilization platform using β-lactoglobulin amyloid fibril hydrogels. Two different hydrogels, loading either RuBisCO alone (hereby termed AFR*) or seven enzymes related to the Calvin Cycle (hereby termed AF7E hydrogel), show immobilization efficiency of over ∼95% while simultaneously exhibiting excellent activity and stability. The AFR* hydrogel enables the fixation of CO2 into 3-phosphoglycerate (3-PGA), which is then utilized as the initial step in the Calvin Cycle cascade catalytic reactions if the AF7E hydrogel is used, mimicking the light-independent part of the more complex natural photosynthesis full process. The converted substrates of this process contain precursors (α-glycerophosphate dehydrogenase and dihydroxyacetone phosphate), which can be further converted to fructose by additional aldolase. Due to the proteinaceous nature of the amyloid substrate, the AF7E hydrogel is completely biodegradable by pepsin, as confirmed via atomic force microscopy and circular dichroism spectroscopy analysis. This original enzyme-amyloid hybrid is biocompatible, sustainable, and scalable and may serve as a general template for multienzymatic catalytic platforms.

A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

Real-time imaging shows how plastic-stuffed cells form clumps that affect mouse movement.

A study assessed 1.2 million biomedical publications and measured the ‘unexpectedness’ of their findings.

War appears to have accelerated the spread of pathogens resistant to antibiotics in the country.

Researchers have described how the bacterium Staphylococcus aureus genetically adapts to humans, including mutations that allow some strains to evade the immune system and become resistant to antibiot...