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Josh Gertler

@joshuagertler.bsky.social
105 followers 227 following 4 posts

Clinical Psych Postdoc at West Haven VA and in Ilan Harpaz Rotem’s Posttraumatic Stress Lab.

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Reposted by Josh Gertler
Bratislav Misic @misicbata.bsky.social · 24/09/2026
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️
doi.org
netneurotools: a trainee-oriented approach to network neuroscience - Nature Protocols
This is a Perspective covering a Python toolbox for neuroscience research that enables users to fetch datasets, construct networks and null models, estimate graph metrics, fit statistical models and v...
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Reposted by Josh Gertler
Matt Mattoni @mattmattoni.bsky.social · 25/03/2026
Precision reward/affect fMRI study out now in HBM! onlinelibrary.wiley.com/doi/10.1002/... @dvsmith.bsky.social @olinotom.bsky.social @coopersharp.bsky.social and @shenghanwang.bsky.social Intensively sampled task + rest fMRI data with behavioral manipulation openly available on OpenNeuro! (1/2)
onlinelibrary.wiley.com
Precision Imaging for Intraindividual Investigation of the Reward Response
We present open data for an intensively sampled precision imaging study including multiple reward-related tasks and a behavioral mood manipulation. Our initial analysis found low test–retest reliabil....
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Reposted by Josh Gertler
Alex Shackman @ajshackman.bsky.social · 27/03/2026
totally unworkable/impractical AND an important step forward - www.sciencedirect.com/science/arti...
sciencedirect.com
Development of a baseline battery to optimize depression treatment assignment in primary care: Balancing breadth and brevity
Psychotherapy and antidepressant medications are effective treatments for depression on average, yet individual response varies widely. Predicting whi…
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Reposted by Josh Gertler
Masud Husain @masudhusain.bsky.social · 28/03/2026
What's the relationship of apathy to depression and anhedonia? Sijia Zhao led our work on this to show that many individuals qualify for the diagnostic criteria of 2 or even 3 of these syndromes. But factor analysis reveals that the syndromes are highly dissociable jnnp.bmj.com/content/earl...
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Awais Aftab @awaisaftab.bsky.social · 13/03/2026
And here’s an accompanying substack post providing an overview of the discussion: www.psychiatrymargins.com/p/the-philos...
psychiatrymargins.com
The Philosophical Foundations of HiTOP
A new paper examines the assumptions behind a new way of classifying mental illness
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Reposted by Josh Gertler
Awais Aftab @awaisaftab.bsky.social · 13/03/2026
A new paper from the HiTOP Revisions Workgroup (and yours truly) on the conceptual and philosophical underpinnings of the framework. Recommended reading for anyone interested in questions of classification and psychopathology! Here’s the journal article: muse.jhu.edu/pub/1/articl...
Paper title: “Examining the Foundational Assumptions of the Hierarchical Taxonomy of Psychopathology” in Philosophy, Psychiatry, & Psychology
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Martin Gell @martingell.bsky.social · 11/03/2026
🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10
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Olav Smeland @olavsmeland.bsky.social · 12/11/2025
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders rdcu.be/ePmwD
rdcu.be
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....
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Jamie Hanson @jamielarsh.bsky.social · 03/11/2025
From big to small: Emerging methods for enhancing precision psychiatry through transfer learning www.sciencedirect.com/science/arti...
sciencedirect.com
From big to small: Emerging methods for enhancing precision psychiatry through transfer learning
Identifying reliable links between individual differences in neurobiological features and differences in symptom profiles or treatment outcomes is a p…
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Reposted by Josh Gertler
Alex Shackman @ajshackman.bsky.social · 03/11/2025
sciety-discovery.elifesciences.org/articles/by?...
sciety-discovery.elifesciences.org
Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression - the PRIME-PRAXOL randomized controlled trial
Here, we examined the efficacy and target engagement of dopamine agonist pramipexole in treating a cross-diagnostic sample of mood disorders characterized by severe anhedonia. Patients with major depr...
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Reposted by Josh Gertler
Nicole Rust @nicolecrust.bsky.social · 01/11/2025
I’m seriously intrigued by this. How are brains set up such that 4 lbs of wonderful in 2 hours doesn’t spiral into mania? That’s robust & highly nontrivial integration!
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Reposted by Josh Gertler
Petter Törnberg @pettertornberg.com · 30/10/2025
Overall social media use is declining. Between 2020 and 2024, more Americans — especially the youngest (18–24) and oldest (65+) — report using no social media at all. A small group of heavy users remains, but the middle is thinning out.
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Nicole Weiss @nicoleweiss.bsky.social · 22/10/2025
Interested in using the PCL-5 to measure PTSD symptoms in your EMA study? We conducted item analysis to examine item thresholds & discrimination parameters & examined DIF across daily surveys www.sciencedirect.com/science/arti...
sciencedirect.com
Psychometric evaluation of the Posttraumatic Stress Disorder Checklist for DSM-5 in daily surveys: An item response theory and longitudinal measurement invariance analysis
The Posttraumatic Stress Disorder (PTSD) Checklist for the DSM-5 (PCL-5) has demonstrated excellent psychometric qualities across cross-sectional stud…
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Steve Fleming @smfleming.bsky.social · 02/10/2025
@matthiasmichel.bsky.social and I are beavering away reading and responding to all the excellent commentaries on our BBS paper outlining an evolutionary account of visual consciousness. In the meantime, if you missed our target article, it's available here: www.cambridge.org/core/journal...
cambridge.org
Sensory Horizons and the Functions of Conscious Vision | Behavioral and Brain Sciences | Cambridge Core
Sensory Horizons and the Functions of Conscious Vision
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moin syed @syeducation.bsky.social · 01/10/2025
PCI Psychology! psych.peercommunityin.org
psych.peercommunityin.org
PCI Psychology
Peer Community in Psychology
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Mark Thornton @markthornton.bsky.social · 03/10/2025
We're a month further into the job market - how are things looking? The good news is that the market does seem to have been delayed: ~150 new listings have appeared since my last post. The bad news is that the total is still substantially lower than what it was during the covid dip.
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Eiko Fried @eikofried.bsky.social · 29/09/2025
Intervening on a central node in a network likely does little given that its connected neighbors will "flip it back" immediately. Happy to see this position supported now. "Change is most likely [..] if it spreads first among relatively poorly connected nodes." www.nature.com/articles/s41...
nature.com
Transformation starts at the periphery of networks where pushback is less - Scientific Reports
Scientific Reports - Transformation starts at the periphery of networks where pushback is less
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Zach Rosenthal @zachrosenthal.bsky.social · 24/09/2025
Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology
nature.com
Arousal as a universal embedding for spatiotemporal brain dynamics - Nature
Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.
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Department of Imaging Neuroscience @imagingneuroucl.bsky.social · 26/09/2025
In this video, Andy Jahn discusses the latest developments in #SPM, the latest release #SPM25 and our recent #SPM Homecoming with the wonderful @corticalpete.bsky.social, @liviasimela.bsky.social and @johmedr.bsky.social. youtu.be/VqzvUPV7pk8?...
youtu.be
SPM Homecoming & SPM25 | Prof. Peter Zeidman, Dr. Olivia Kowalczyk & Dr. Johan Medrano
YouTube video by Andy's Brain Tube
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Jingnan Du @jingnandu.bsky.social · 26/09/2025
Our new paper is out now in Neuron! 🎉 With @vaibhavtripathi.bsky.social @maxwellelliott.bsky.social Joanna Ladopoulou, Wendy Sun, Mark Eldaief, and Randy Buckner Paper link: www.sciencedirect.com/science/arti...
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Michael W. Cole @mwcole.bsky.social · 14/09/2025
Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n
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Thomas Yeo @bttyeo.bsky.social · 17/07/2025
8/ In contrast to standard power calculations, our results suggest that jointly optimizing sample size and scan time can boost prediction accuracy while cutting costs. For more complex study design, you can check out our calculator: thomasyeolab.github.io/OptimalScanT...
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Thomas Yeo @bttyeo.bsky.social · 17/07/2025
1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...
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Juliette Brook @juliettebrook.bsky.social · 06/05/2025
Dreaming of a dataset that tracks mood, sleep & activity to better understand affective instability (AI)…AND paired with advanced MRI? 🤯 Check out our new bioRxiv preprint for a 13–23 y/o community sample (n=10 and growing!) with multi-echo fMRI, EMA & actigraphy: www.biorxiv.org/content/10.1...
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Nicole Rust @nicolecrust.bsky.social · 25/04/2025
A putative neural correlate of mood! One big (scandalous?) idea, simple analyses, and the STRONGEST brain/behavior correlation I've EVER seen (which is shocking, given that it's mood). Work with: You-Ping Yang, @catrinahacker.bsky.social and Veit Stuphorn. www.biorxiv.org/content/10.1...
biorxiv.org
The representation of mood in primate anterior insular cortex
Understanding how the brain reflects and shapes mood requires resolving the disconnect between behavioral measures of mood that can only be made in humans (typically based on subjective reports of hap...
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Reposted by Josh Gertler
Sam Krimmel @samkrimmelneuro.bsky.social · 10/04/2025
It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy
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Karl Friston News @karlfristonnews.bsky.social · 07/04/2025
Comment: "Can a single brain cell be surprised?" www.nature.com/articles/s41...
nature.com
Can a single brain cell be surprised? - Nature Communications
A recent study by Buonomano et al. reports two important contributions; namely, empirical evidence for prediction error-like responses in single cells, using ex vivo preparations and optogenetics. Sec...
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Thomas Yeo @bttyeo.bsky.social · 26/03/2025
It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠
nature.com
A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications
Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.
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Thomas Yeo @bttyeo.bsky.social · 24/01/2025
Thanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula... The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵
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Alex Shackman @ajshackman.bsky.social · 23/03/2025
#gFC - scholar.google.com/citations?vi...
scholar.google.com
‪Test–retest reliability and predictive utility of a macroscale principal functional connectivity gradient‬
‪AR Knodt, ML Elliott, ET Whitman, A Winn, A Addae, D Ireland, R Poulton, S Ramrakha, A Caspi, TE Moffitt…‬, ‪Human brain mapping, 2023‬ - ‪Cited by 14‬
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Alex Shackman @ajshackman.bsky.social · 23/03/2025
ManyShortT1s - direct.mit.edu/imag/article...
direct.mit.edu
Precision brain morphometry using cluster scanning
Abstract. Measurement error limits the statistical power to detect group differences and longitudinal change in structural MRI morphometric measures (e.g., hippocampal volume, prefrontal cortical thic...
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Reposted by Josh Gertler
Kevin Mitchell @wiringthebrain.bsky.social · 14/03/2025
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊
onlinelibrary.wiley.com
Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience
The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...
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CLaE @claeneuro.bsky.social · 10/03/2025
Nature Neuroscience The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow www.nature.com/articles/s41...
nature.com
The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow - Nature Neuroscience
The default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to input from the sensor...
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Alessandro Gozzi @gozziale.bsky.social · 06/03/2025
Can we use brain scans to identify biologically distinct "autisms"? And If so, how? In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions! Find out more here 👇👇 www.biorxiv.org/content/10.1... Thread below 🧵 1/n
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Steve Fleming @smfleming.bsky.social · 21/02/2025
Excited to see this now out in the world! We identify a computational basis for how persistent underconfidence is maintained in the face of intact performance, finding that it is grounded in impaired updating of global self-beliefs from local metacognition www.nature.com/articles/s41... 1/N
nature.com
Distorted learning from local metacognition supports transdiagnostic underconfidence - Nature Communications
Individuals with symptoms of anxiety and depression exhibit persistent underconfidence. Here, the authors show that distortions in learning from local metacognition can explain how underconfidence is ...
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Mel Goodale @action-brain.bsky.social · 24/02/2025
I don’t know how I missed this. A group in Beijing have developed an effective brain-inspired vision chip for autonomous machines, robotics, and AI that was inspired by our perception/action account of ventral-dorsal visual processing in primate cerebral cortex.🧪🧠 www.nature.com/articles/s41...
nature.com
A vision chip with complementary pathways for open-world sensing - Nature
Inspired by the human visual system, a vision chip with primitive-based complementary pathways is developed to overcome the power and bandwidth wall of vision systems, achieving fast, precise, robust&...
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Jeremy Berg @jeremymberg.bsky.social · 22/02/2025
The FDA recently approved a novel pain medication developed by Vertex, Journavx (suzetrigine) www.fda.gov/news-events/... 1/n
fda.gov
FDA Approves Novel Non-Opioid Treatment for Moderate to Severe Acute Pain
The FDA approved Journavx (suzetrigine) 50 mg oral tablets, a first-in-class non-opioid analgesic to treat moderate to severe acute pain in adults.
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Josh Gertler @joshuagertler.bsky.social · 09/02/2025
The white house tried and failed to do this 2017, and will fail again. Also, a good exploration of real ways to increase efficiency and reduce waste in NIH grant funding open.substack.com/pub/goodscie...
open.substack.com
Indirect Costs at NIH . . .
I wasn’t planning on spending part of a Saturday writing about cost accounting principles and the like, but NIH-world was hit with a doozy of a policy announcement on Friday night:
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Cameron Pugach @cppugach.bsky.social · 04/02/2025
An Idiographic Network Approach to Posttraumatic Stress Disorder: Symptom Heterogeneity and Implications for Treatment link.springer.com/article/10.1...
link.springer.com
An Idiographic Network Approach to Posttraumatic Stress Disorder: Symptom Heterogeneity and Implications for Treatment - Cognitive Therapy and Research
Background Despite significant advances in the treatment of posttraumatic stress disorder (PTSD), heterogeneity in symptom presentation and high rates of comorbidity with other mental health condition...
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Aaron Fisher @aaronjfisher.bsky.social · 03/02/2025
Are we still promoting science in these days of woe? Here's a gift link to a fantastic new paper from @mattmattoni.bsky.social and @olinotom.bsky.social. www.sciencedirect.com/science/arti...
sciencedirect.com
Group-to-individual generalizability and individual-level inferences in cognitive neuroscience
Much of cognitive neuroscience research is focused on group-averages and interindividual brain-behavior associations. However, many theories core to t…
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Awais Aftab @awaisaftab.bsky.social · 19/01/2025
The Unbearable Incoherence of Heritability: Interview with Eric Turkheimer ( @ent3c.bsky.social ) “The empirical end to the Galtonian project is more whimper than bang.” www.psychiatrymargins.com/p/the-unbear...
psychiatrymargins.com
The Unbearable Incoherence of Heritability: Interview with Eric Turkheimer
Eric Turkheimer is Hugh Scott Hamilton Professor of Psychology at University of Virginia.
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Awais Aftab @awaisaftab.bsky.social · 01/02/2025
Confessions of an Ambivalent Psychiatrist A guest essay by the psychiatrist Susan Mahler on her experience of depression (including treatments with ECT) and how she finds herself in a position where both lived and professional experience are failing her www.psychiatrymargins.com/p/confession...
psychiatrymargins.com
Confessions of an Ambivalent Psychiatrist
Susan Mahler, MS, MD, is a writer and psychiatrist who practices in North Adams, MA.
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Janan Mostajabi @jananmost.bsky.social · 30/01/2025
New preprint! 🚨 osf.io/preprints/ps... Traditional categorial frameworks, like the DSM and the ICD, have several key limitations, including heterogeneity within diagnoses, comorbidity issues, arbitrary categorical boundaries, and limited clinical application and utility. 1/
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Martin Lindquist @fmristats.bsky.social · 27/01/2025
To learn more about the imaging data see the following paper: www.biorxiv.org/content/10.1... For more information about the study and how to download the data see: a2cps.org More data coming soon!
biorxiv.org
Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project
The Acute to Chronic Pain Signatures (A2CPS) project is a large-scale, multi-site initiative aimed at identifying biomarkers and biosignatures that predict the transition from acute to chronic pain. T...
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CLaE @claeneuro.bsky.social · 26/01/2025
TRANSMITTER Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control www.thetransmitter.org/basal-gangli...
thetransmitter.org
Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control
The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.
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CLaE @claeneuro.bsky.social · 24/01/2025
Trends in Cognitive Sciences The Thermodynamics of Mind id.elsevier.com/as/authoriza...
id.elsevier.com
The Thermodynamics of Mind
To not only survive, but also thrive, the brain must efficiently orchestrate distributed computation across space and time. This requires hierarchical organisation facilitating fast information transf...
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Karl Friston News @karlfristonnews.bsky.social · 24/01/2025
Article: "SPM 25: open source neuroimaging analysis software" arxiv.org/abs/2501.12081
arxiv.org
SPM 25: open source neuroimaging analysis software
Statistical Parametric Mapping (SPM) is an integrated set of methods for testing hypotheses about the brain's structure and function, using data from imaging devices. These methods are implemented in ...
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Nature Reviews Neuroscience @natrevneuro.nature.com · 17/01/2025
The brain’s action-mode network — a Perspective by Nico U. F. Dosenbach, Marcus E. Raichle & Evan M. Gordon @ndosenbach.bsky.social @gordonneuro.bsky.social www.nature.com/articles/s41...
nature.com
The brain’s action-mode network - Nature Reviews Neuroscience
The brain enters an action-mode of function during goal-directed behaviour. In this Perspective, Dosenbach, Raiche and Gordon describe “action-mode” as an informative functional label that reduce...
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