An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

Focus must now switch to limiting extent of overshoot, says United Nations' climate report

Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.

Serotonergic neurons in the dorsal raphe nucleus (DRN) project extensively throughout the forebrain, yet their influence on global network states remains controversial. Serotonin is implicated in regu...

Rotating neuronal waves are built into brain anatomy and help coordinate far-flung regions, mouse imaging study suggests

A lightweight head-mounted multiplane microscope allows simultaneous imaging from >1,800 neurons spread across the cortical layers in freely moving mice performing complex behavioral tasks, sampled...

Disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data.

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Nature - De novo design of miniproteins targeting GPCRs

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

YouTube video by A Curious Birb

PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Two-photon imaging and pupillometry reveal how arousal modulates excitatory neuron subtypes in auditory cortex.

These glial cells are increasingly linked to neurodevelopmental conditions and the regulation of social behaviors and anxiety.

YouTube video by Filip Tomáška

Ghenissa et al. provide evidence that basolateral amygdala astrocytes reliably encode anxiety states. Using simultaneous in vivo calcium recordings across an array of behavioral tasks, combined with g...

The glial cells’ activity reliably tracks with freezing, hesitancy and other behaviors reminiscent of anxiety.

Intrinsic optical imaging (IOI) is a powerful approach to record visual-functional maps across the mouse superior colliculus (SC) and primary visual c…

Rhodopsin-based GEVIs were thought to lose voltage sensitivity with two-photon excitation, limiting their utility for deep in vivo imaging. We introduce Jarvis, a bright and photostable GEVI, and demonstrate that, along with pAce and Voltron2, it enables high-contrast two-photon voltage imaging and AP detection at kilohertz rates.

Blanco-Suárez revamped the traditional journal club by developing a course in which students peer review preprints alongside the published papers that evolved from them.

The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.