Our new preprint ab a developmental mechanism reused in response to injury🧠 Chrdl1, an astrocytic regulator of synaptic maturation, is re-engaged after stroke to regulate GluA2 and neuronal vulnerability. The twist: effects depend on when and where it is expressed.
www.biorxiv.org/content/10.6...
biorxiv.org
Astrocytic chordin-like 1 (Chrdl1) is re-engaged early after ischemic stroke to regulate region-dependent GluA2 levels and neuronal vulnerability
Neuronal vulnerability to ischemic stroke varies markedly across brain regions, yet the mechanisms underlying this selective susceptibility remain poorly understood. Here, we show that the development...
