iiinova — where your digital self keeps evolving

Jakub Began

@jakubegan.bsky.social

Protein biochemist, hiker, floorball player

Jakub Began @jakubegan.bsky.social · 12/09/2026

⚠️ REVIEW ALERT 🤓 I'm happy to share our new review, where we discuss recent discoveries on lipopolysaccharide recognition by non-canonical inflammasome and highlight the key questions scientists still need to answer. portlandpress.com/biochemsoctr... Check comments for more details👇

portlandpress.com

When folding CARDs wins the game: molecular snapshots of lipopolysaccharide sensing by the non-canonical inflammasome

Abstract. Inflammatory caspases play essential roles in regulating IL-1 cytokine processing and secretion, as well as in inducing pyroptosis as part of the innate immune response to pathogens and othe...

152

Reposted by Jakub Began

corrylab.bsky.social @corrylab.bsky.social · 27/05/2026

Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...

413137

Jakub Began @jakubegan.bsky.social · 27/04/2026

In Lausanne, we have an incredible environment for research, and our immunology hub is truly thriving! I’m proud to be part of it 👇

120

Reposted by Jakub Began

Broz Lab @brozlab.bsky.social · 26/03/2026

Finishing up in snowy Banff with current and former Broz Lab members after the innate immunity symposium. @jakubbegan.bsky.social @kaiwenchen-lab.bsky.social @ehartenian.bsky.social @keystonesymposia.bsky.social

072

Jakub Began @jakubegan.bsky.social · 16/02/2026

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

cell.com

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

3287