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Daniel Lüdke

@danielluedke.bsky.social
780 followers 187 following 1 posts

🌱Plant Biologist🌱 Post-doc @thesainsburylab.bsky.social | he/him

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Reposted by Daniel Lüdke
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
Excited to share this pre-print from my PhD work! We explore a Pmk1-Mst12-Bip1 network required for appressorium-mediated infection by the blast fungus 🌾 www.biorxiv.org/content/10.6... Thread 👇
biorxiv.org
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
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Diana Gómez De La Cruz @dianagdlc.bsky.social · 05/06/2026
So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇 www.science.org/doi/10.1126/...
science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
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Jiorgos Kourelis @jiorgoskourelis.bsky.social · 04/06/2026
📢 PDRA Position - Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Aug 2026 (flexible) 🧪 Wet lab + bioinformatics 📅 Up to 3 years (ERC-funded) 📍 South Kensington, on site ℹ️ shorturl.at/VIITk 🔗 kourelislab.com #PlantImmunity #PlantPathology 🙏 Share with interested candidates!
shorturl.at
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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KhongSam Chia @khongsamchia.bsky.social · 22/05/2026
Preprint Alert 🚨 @philcarella.bsky.social lab stepping into TIR-ritory!! Project started by me but finished by talented PhD student @ebkennedy.bsky.social (Please follow her), with contribution from Zhao He and @jonathandgjones.bsky.social We investigated EDS1-dependency of TIR domain. See thread👇
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Phil Carella @philcarella.bsky.social · 22/05/2026
Check out our latest pre-print on the evolution of TIR activity/signalling: www.biorxiv.org/content/10.6...
biorxiv.org
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Elenor Kennedy @ebkennedy.bsky.social · 22/05/2026
@khongsamchia.bsky.social Extremely excited to share the first pre-print from my PhD project in the Carella lab, co-first authored with @khongsamchia.bsky.social 🎉 (Thread below ⬇️) www.biorxiv.org/content/10.6... Huge thanks to all co-authors and the #CarellaCapybaras for all the support 😊
biorxiv.org
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The Tattooed Professor @schwessinger.bsky.social · 11/05/2026
Finally made it.... congratulations all.
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Hsuan Pai 白暄 @hsuanpai.bsky.social · 01/05/2026
End of April and I got my diploma🥂 Now the PhD degree is official! I hope I've mentioned everyone in my acknowledgments, but I still can’t thank you enough for all the support along this journey: ) If anyone's looking for some 400-page light reading… here it is ➡️ ueaeprints.uea.ac.uk/id/eprint/10...
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Larry Hunter @proflhunter.bsky.social · 06/05/2026
Fun thread. Cool work, and make sure to read all the way to the end!
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The Sainsbury Laboratory @thesainsburylab.bsky.social · 06/05/2026
New Preprint in collaboration with GoogleDeepMind: AI-guided discovery of atypical protein assemblies The @kamounlab.bsky.social discovered an 11-protomer complex thanks to the Structural Novelty Index , a new way to use AlphaFold to find protein assemblies that break the pattern.
tsl.ac.uk
AI-guided discovery of atypical protein assemblies
Artificial intelligence (AI) systems such as AlphaFold have transformed structural biology by enabling accurate prediction of protein structures. However, their capacity to uncover new classes of…
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Sophien Kamoun @kamounlab.bsky.social · 06/05/2026
Just published: Breaking the Pattern with AlphaFold: Introducing the Structural Novelty Index AlphaFold has transformed how we predict protein structures. But sometimes most interesting discoveries come from asking a different question: which proteins break the pattern? medium.com/p/breaking-t...
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Daniel Lüdke @danielluedke.bsky.social · 06/05/2026
Some predictions are high-confidence. These go to eleven! Huge congrats to the whole team ❤️ Such a privilege to work with you all.
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AmirAli Toghani @amiralito.bsky.social · 05/05/2026
UP TO ELEVEN - We expressed potato NRC7, imaged it by negative-stain EM, ran 2D classification. 🔬💥 Rings ~250 Å across — way bigger than canonical hexamers (~150 Å). 11 protomers. (5/n)
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bioRxivpreprint @biorxivpreprint.bsky.social · 04/05/2026
AI-guided discovery of atypical protein assemblies www.biorxiv.org/content/10.64898/20…
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 04/05/2026
AI-guided discovery of atypical protein assemblies www.biorxiv.org/content/10.64898/20…
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Clémence Marchal @clemmar.bsky.social · 03/12/2025
Excited to share our latest work on plant immune receptor biochemistry! @kamounlab.bsky.social @hsuanpai.bsky.social @mpcontreras.bsky.social Jose Salguero Linares @danielluedke.bsky.social @adnroide.bsky.social @jiorgoskourelis.bsky.social www.biorxiv.org/content/10.6...
CC-NLRs exhibit diverse conformations in the resting state.
Figure depicts different NLR resting and activated states. While ZAR1 exists as a monomer bound to its guardees in its resting state, several forms have been observed for the NRC2 helper, including dimers, tetramers, and filaments. While filament-like structures were observed via confocal microscopy for NRC2 upon overexpression in planta, these structures were not detected for its paralog NRC4, suggesting a potentially different resting state configuration for NRC4. Our work suggests that the Pik CC-NLR pair forms a hetero-complex bound to the plasma membrane in its resting state. How effector binding to the integrated domain (ID) of the Pik-1 sensor leads to the activation of the complex remains to be determined.
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Cristobal Uauy @cristobaluauy.bsky.social · 07/01/2025
1/10 We are thrilled to share our preprint on spatial transcriptomics in wheat spikes led by the amazing @katielong.bsky.social and Ashleigh Lister. We resolved expression of 200 genes to cellular resolution. Pre-print👉 tinyurl.com/c7t3kncf., @johninnescentre.bsky.social @earlhaminst.bsky.social
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Richard Sever @richardsever.bsky.social · 21/12/2024
Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2
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Marc Somssich @somssich.bsky.social · 21/12/2024
Germany's ZB MED signs publishing partnership agreement with MDPI. At a time when MDPI is considered predatory to most, this is a baffling move. 🤑🤢 Doesn't reflect good on #BioMedicalResearch in Germany. www.mdpi.com/about/announ... #SciPub #ScientificPublishing #PredatoryPublishers #OpenAccess
mdpi.com
Over 100 German Universities Partner with MDPI in New National Agreement
More than 100 German universities and research institutions have entered into a national agreement with MDPI. The publication agreement negotiated...
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Sophien Kamoun @kamounlab.bsky.social · 10/12/2024
From predoc to postdoc… The legendary Nef @NeftalyCM 🇲🇽 is moving on for some Swiss adventures! Thank you Nef for all your contributions to @TheSainsburyLab science and way beyond… What a gentleman! #CelebratingAlumni
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Alex McClelland @alexjmcclelland.bsky.social · 04/12/2024
Very pleased to have passed my PhD viva today! Thank you Núria and @jonathandgjones.bsky.social for serving as my examiners and to Wenbo for your supervision and guidance! Has been a really great experience at @thesainsburylab.bsky.social! Photo courtesy of @stephbornemann.bsky.social
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Frank Menke @frankmenke.bsky.social · 09/12/2024
Huge congratulations to @draegermarkus.bsky.social for passing his viva today @thesainsburylab.bsky.social. Thank you for @saskiahogenhout.bsky.social and Julia Santiago acting as examinars. #Veryproudsupervisor!
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Megan McDonald @mcdonaldmeganc.bsky.social · 07/12/2024
HI old friends! Finally took the leap here to say I have several open positions going in my lab at the moment (and more to come). 1) PhD studentship in collaboration with the Royal Horticultural Society (genomics) 2) Biochemistry Postdoc to understand how Starships move Check out the links below!
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Jiorgos Kourelis @jiorgoskourelis.bsky.social · 04/12/2024
📢 PhD Opportunity in my lab on Plant Immune Receptor Bioengineering at @imperiallifesci.bsky.social 🌱 Start: October 2025 📅 Deadline: 12th January 2025 🇬🇧 Open to UK students 💰 Fully funded ℹ️ More info: tinyurl.com/w6ap9v9f ❗ #PlantImmunity #PlantPathology 🙏 Please share with interested candidates!
findaphd.com
Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London on FindAPhD.com
PhD Project - Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London, listed on FindAPhD.com
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Tracy Palmer @proftracypalmer.bsky.social · 03/12/2024
Is this not the finest lab crafted Christmas tree decoration you’ve ever seen? Courtesy of Amy Tooke!
A reindeer crafted from epoendorf tubes and pipette tips A reindeer crafted from eppendorf tubes and pipette tips
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Ksenia Krasileva @kseniakrasileva.bsky.social · 05/12/2024
Several Jedis in our lab joined forces to review the rise of the plant immune resistance at DNA, RNA, and protein levels 💫🚀 check out the preprinted review here: zenodo.org/records/1420...
zenodo.org
The Resistance Awakens: Natural diversity informs engineering of plant immune receptors at the DNA, RNA, and protein levels
Plants rely on germline-encoded, innate immune receptors to sense pathogens and initiate the defense response. The exponential increase in quality and quantity of genomes, RNA-seq datasets, and protei...
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Juan (胡安) @angiopteris.bsky.social · 05/12/2024
Excited to share the fruits of my PhD! www.biorxiv.org/content/10.1...
biorxiv.org
Rhizobium rhizogenes A4-derived strains mediate hyper-efficient transient gene expression in Nicotiana benthamiana and other solanaceous plants
Agroinfiltration, a method utilizing agrobacteria to transfer DNA into plant cells, is widely used for transient gene expression in plants. Besides the commonly used Agrobacterium strains, Rhizobium r...
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Sophien Kamoun @kamounlab.bsky.social · 02/12/2024
NEW!!! Can AI distinguish between sensor and helper NLRs? #NLRbiology 👇🏼
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 14/12/2023
A root-specific NLR network confers resistance to plant parasitic nematodes www.biorxiv.org/content/10.1101/202…
biorxiv.org
A root-specific NLR network confers resistance to plant parasitic nematodes https://www.biorxiv.org/content/10.1101/2023.12.14.571630v1
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) confer disease resistance
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GetGenome @getgenome.bsky.social · 09/11/2023
We’re speaking at the @TheSainsburyLab Autumn Symposium 🙏 getgenome.net/impact
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Adam Bentham @adamrbentham.bsky.social · 08/11/2023
Our work on a Phytophthora WY effector that hijacks a host is now out in MPMI! Check it out here: doi.org/10.1094/MPMI...
doi.org
The WY domain of an RxLR effector drives interactions with a host target phosphatase to mimic host r...
Plant pathogens manipulate the cellular environment of the host to facilitate infection and colonization, often leading to plant diseases. To accomplish this, many specialized pathogens secrete virule...
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Angus Bucknell @ahbucknell.com · 26/10/2023
Great time at the TSL student/postdoc pumpkin carving social today! 🎃 📸 by Matt Wengler
25 carved pumpkins in a line lit with tea lights. The reflection of the pumpkins can be seen in the water of a pond in front of them.
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