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Yori Dola

@gene-boy.bsky.social
1.1K followers 243 following 200 posts

Plant gene editor 🧑‍🔬🌿🧬🔧 Making plants resistant to diseases 🦠🔨 Former hippy 🌺, now a scientist 🧪 Postdoc at the Jonathan Jones Lab, TSL

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Yori Dola @gene-boy.bsky.social · 03/08/2026
We need to inform society!
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European Commission @ec.europa.eu · 01/08/2026
Japan has now joined Horizon Europe. Japan’s researchers can now partner with teams across the EU. Together, we will advance global research in health, digital technologies, and climate neutrality ↓ link.europa.eu/YP7MtB
Visual featuring Mount Fuji framed by pink cherry blossoms. At the centre are the overlapping flags of the European Union and Japan, with the text "EU-JAPAN HORIZON EUROPE" overlaid below.
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Yori Dola @gene-boy.bsky.social · 22/07/2026
Highly suspicious claim turns out to be baseless 😮 truly shocked NHS England adds caveat to pro-Palantir data after watchdog probe - giftarticle.ft.com/giftarticle/... via @FT
giftarticle.ft.com
NHS England adds caveat to pro-Palantir data after watchdog probe
Regulator urges health service to ensure communications about benefits are ‘clearly and appropriately labelled’
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Richard Sever @richardsever.bsky.social · 06/07/2026
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
biorxiv.org
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
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Sophien Kamoun @kamounlab.bsky.social · 25/06/2026
Magic benthi! 🍄 🌱 Psychedelic Nicotiana benthamiana wasn’t on my 2026 synbio bingo card www.science.org/doi/10.1126/...
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Yori Dola @gene-boy.bsky.social · 22/06/2026
#PlantDisease news 📃! Great new preprint from Xinnian Dong's lab on a nucleoporin (Nup58) mechanically linking Ca++ influx with ETI! Good work on what is still a pretty open question. www.biorxiv.org/content/10.6...
biorxiv.org
Ca2+-activated CKL3 phosphorylates nucleoporin 58 to reprogram nuclear transport and execute effector-triggered immunity
Recognition of pathogen effectors by nucleotide-binding leucine-rich repeat receptors (NLRs) activates effector-triggered immunity (ETI) in plants through resistosome formation, which generates a sust...
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parkergroup.bsky.social @parkergroup.bsky.social · 09/06/2026
TIRs are key regulators of plant immunity, but the role of conserved TIR-only proteins has remained unclear. Here, we compare TIR-only proteins from Arabidopsis and barley and show that they share a conserved role in plant immunity. www.biorxiv.org/content/10.6...
biorxiv.org
Conserved TIR-only proteins drive transcriptional defense and basal immunity in dicot and monocot plants
Toll/interleukin-1/resistance (TIR) domain NADase enzymes signal in plant immunity by producing ribosylated nucleotide second messengers which activate EDS1 dimer-helper NLR pathways to restrict patho...
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Plant Science Spotlight @plant-sci.bsky.social · 04/06/2026
🍇🧬Optimized hairy root protocol for grapevine. Tested multiple strains, cultivars & explants. Universal primers confirm transformation. DsRed reporter works well. Overexpressed VviMYBA1 turns roots red First CRISPR edited grapevine hairy roots reported #plantscience academic.oup.com/jxb/advance-...
academic.oup.com
Optimized protocol for efficient generation, confirmation, transformation, and CRISPR editing of grapevine hairy roots
Optimized workflows and methods are provided for the establishment of Rhizobium rhizogenes-mediated transgenic or CRISPR-edited hairy root cultures for gra
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Mauricio Contreras @mpcontreras.bsky.social · 04/06/2026
Molecular mimicry of a pathogen virulence target by a plant immune receptor | Science www.science.org/doi/10.1126/...
science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
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Yori Dola @gene-boy.bsky.social · 04/06/2026
Years ago, research linked ultra-processed foods and obesity. Unsurprising However, this was misconstrued - somehow the processing was blamed, not the contents. Oddly, this led to items like plant yogurts labelled as bad for you The science is in: it's the contents www.science.org/doi/10.1126/...
science.org
Ultraprocessed foods and obesity: Interpreting the evidence
What do randomized controlled trials really tell us about the effects of ultraprocessed foods?
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Plant Disease @plantdiseasej.bsky.social · 25/05/2026
#Apiospora marii is an ascomycete recently associated with olive tree dieback in Italy and Spain. Giuseppe Incampo et al. developed a quantitative PCR and a digital droplet PCR for its detection: doi.org/10.1094/PDIS-03-25-0635-SR #plantdisease #plantpathology
Fig. 3.
Validation of the Apiospora marii AM158 molecular assay. A, The qPCR linear regression obtained using the DNA extracted from different A. marii conidia amounts added to healthy olive wood. B, Symptoms observed on olive wood in the longitudinal and transversal sections from which A. marii was isolated, and morphology of colony and conidia of 7-dai PDA culture. C, qPCR and ddPCR results were obtained using DNA from mock, artificially inoculated, and symptomatic plants and from olive plants naturally infected by A. marii according to the diagnostic method and confirmed by morphological and molecular analyses. qPCR, quantitative PCR; ddPCR, digital droplet PCR; dai, days after inoculation; PDA, potato dextrose agar.
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Michael LaFrance @mlafrance.bsky.social · 25/05/2026
A livestream of a volcano in the Philippines captured a meteor crashing to Earth today. What are the odds? Mayon Volcano, Location: Albay, Luzon, Philippines
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Lee Cronin’s Pablo Hidalgo @infinata.bsky.social · 25/05/2026
$2.5 trillion well spent.
AI Overview

There is exactly 1 letter "r" in the word "cookie" (c-o-o-k-i-e).
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AmirAli Toghani @amiralito.bsky.social · 20/05/2026
Started off as convergent observations in the lab with Mau and led to one of my favorite works so far! Gotta love molecular evolution and receptor biology 😊🧬💻 Huge effort from @maigarro.bsky.social @mpcontreras.bsky.social for pushing this together to the end. 🤘🏻
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Alan Schulman @alanhschulman.bsky.social · 19/05/2026
Next up: green sunbathers lining the beach. www.nature.com/articles/d41...
nature.com
Mouse eyes photosynthesize after plant-to-animal transplant
Could spinach extracts be the next treatment for dry-eye disease?
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Christine Faulkner @pdchristine.bsky.social · 19/05/2026
Emma Turley started her PhD expecting the effector ChEC108 would aid Colletotrichum establish infection, but she instead discovered that when it makes it's way to plasmodesmata it's bound by host HIPP6, triggering PD closure and impeding infection. #PlantScience
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Adam Steinbrenner @adsteinbrenner.bsky.social · 13/05/2026
We are excited to release the BAT!🦇🚨 We've used this phylogenetic analysis pipeline in our lab for years, and grad Ben Sheppard now presents a Github release and preprint. I run BAT analyses almost daily. It makes exploring gene families routine, customizable, and fun🧵
pipeline logo
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Helena Watson @helenawatson.bsky.social · 25/04/2026
Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)
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Cheshire @thatsregrettab1.bsky.social · 25/04/2026
For those who missed this at the other place: open.substack.com/pub/mikhoeli...
open.substack.com
How AI Breakthrough Could Shake the Scientific Publishing Process
Recent Image generation and LLM models are so good they can produce digital assets nearly undistinguishable from genuine ones.
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Carl T. Bergstrom @carlbergstrom.com · 17/04/2026
More seriously, be wary of trillion-dimensional spaces. As long as they are the same model, the teacher model teaches the student model to prefer owls simply by transmitting sequences of numbers. www.nature.com/articles/s41...
nature.com
Language models transmit behavioural traits through hidden signals in data - Nature
During model distillation, large language models can subtly transmit traits unrelated to the training data.
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Carlos Ribeiro @ribeirocarlitos.bsky.social · 17/04/2026
Today we mourn the passing of our beloved central dogma. It served Crick well. But it is time to let go. www.science.org/doi/10.1126/...
science.org
Science | AAAS
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Nature Plants @natplants.nature.com · 14/04/2026
New Article: "A fungal nuclease effector subverts the chloroplast genome and triggers cell death to promote infection" rdcu.be/fdgOE MoNee6 is a chloroplast-targeted nuclease from Magnaporthe oryzae. Engineering OsClpP1 enhances Nee6 degradation and blast resistance.
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Yori Dola @gene-boy.bsky.social · 12/04/2026
Crispy toast enjoyers, rejoice! Fantastic to see Gene Editing being allowed to do some good in Europe.
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Sarah Taber @sarahtaber.bsky.social · 11/04/2026
Fancy word of the day: pollenkitt An oily, waxy, sticky goo that plants that are pollinated by insects, bats, & birds put on top of their pollen so that it -sticks to pollinators -doesn't blow away in the wind (hypoallergenic!!) -has extra tasty calories for the pollinators maybe
Pic of a shiny green bee with black wings on a flower, getting covered in heavy golden pollen
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Alisia Fadini @alisiafadini.bsky.social · 01/04/2026
ROCKET 🚀 inference-time optimization of AlphaFold to fit structural data is published! rdcu.be/fa9YH Since our preprint, we’ve pushed it to regimes where other methods break: low resolution, weak signal, real experimental edge cases. Here’s what we learned: 1/15
rdcu.be
AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network
Nature Methods - ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray...
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Journal of Experimental Botany @jxbotany.bsky.social · 30/03/2026
🌿🐛 RESEARCH 🐛🌿 Screening 99 purslane accessions identified aphid-susceptible and -resistant lines. Integrated transcriptomics and metabolomics show TPS genes regulate d-limonene and myrcene, underlying variation in aphid resistance – Xu et al. 🔗 doi.org/10.1093/jxb/... #PlantScience 🧪
Fig. 3 (shortened, full legend in paper): Transcriptome analysis of accessions no. 66 (HS) and no. 119 (HR) before and after aphid infestation. (A) Experiment design of aphid infestation and transcriptome sample collection. (B) Heatmap of sample correlation. Dark green indicates high correlation, while white or light green indicate low correlation. (C) PCA of all samples. Each point represents a single sample, and shapes indicate different experimental groups (D1190d, D1195d, D1199d, D660d, D664d, and D669d). The x-axis (Dim1) and y-axis (Dim2) represent the first and second principal components, which explain 54.7% and 24.3% of the total variance, respectively. Confidence ellipses indicate the 90% confidence intervals for different accessions. (D) Bar plot showing the number of differentially expressed genes (DEGs) in six pairwise comparisons across time points. Up-regulated genes are shown in green, and down-regulated genes in orange.
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Robert Hoffie @forscherrobert.bsky.social · 26/03/2026
#GiveGenesAChance in UK 🌾 www.rothamsted.ac.uk/news/rothams...
rothamsted.ac.uk
Rothamsted gene-edited barley crop becomes first to receive a UK Precision Bred Organism marketing notice | Rothamsted Research
A gene-edited barley developed by scientists at Rothamsted Research has become the first crop to receive a Precision Bred Organism (PBO) marketing notice confirmation through the UK’s new regulatory p...
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Marc Somssich @somssich.bsky.social · 24/03/2026
#PlantScienceClassics #20: Kinetin & Cytokinins. In 1955 Carlos Miller, Folke Skoog & co-workers describe the first #Cytokinin and its role in promoting cell division and growth promotion. #Phytohormones #PlantScience #PlantDevelopment pubs.acs.org/doi/abs/10.1... pubs.acs.org/doi/abs/10.1...
The authors of the two papers. Carlos O. Miller standing on the left, looking down upon a couple of glass beakers. Opposite him, from the back to the front, are Malcolm H. van Saltza, Francis Shigeo Okumura, Folke K. Skoog and Frank M. Strong. Below the photo are the headers of their two papers describing kinetin, the first cytokinin: “Kinetin, a cell division factor from desoxyribonucleic acid” by Carlos O. Miller, Folke K. Skoog, Malcolm H. van Saltza and Frank M. Strong, and “Structure and synthesis of kinetin” by Carlos O. Miller, Folke K. Skoog, Francis Shigeo Okumura, Malcolm H. van Saltza and Frank M. Strong. Both published in 1955 in the Journal of the American Chemical Society.
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Mary Williams @PlantTeaching @plantteaching.bsky.social · 26/03/2026
Wow, this is the most intriguing title I've seen this year. It's an interesting paper too!
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The Sainsbury Laboratory @thesainsburylab.bsky.social · 23/03/2026
Do you have a PhD in plant science 🌿 and are you excited by the commercial application of research? Do you want to grow your skills in IP management?💡 We have an exciting opportunity for you ⬇️ VACANCY: TSL Ventures Operations Officer www.tsl.ac.uk/working-at-t... Apply before 7 April '26
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Piotr Ziolkowski @piotraz.bsky.social · 13/03/2026
📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱 Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina! www.science.org/doi/10.1126/...
science.org
Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis
Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.
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Yori Dola @gene-boy.bsky.social · 01/03/2026
I think everyone should watch this government-funded infomercial youtu.be/T4Upf_B9RLQ
youtu.be
A Day in the Life of an Ensh*ttificator
YouTube video by Forbrukerrådet - Norwegian Consumer Council
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Laurens Pauwels @laurenspauwels.bsky.social · 18/02/2026
Golden Gate 🧬 builds complex T-DNAs for plant transformation & gene editing — but what if we used it to make binary vector backbones? Glad to contribute to Jonas De Saeger's (Jacobs lab @psb-vib.bsky.social ) preprint on BackBone Builder 🔧🌱 tinyurl.com/4ycydjhe
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Yori Dola @gene-boy.bsky.social · 18/02/2026
When viruses force the cell to make viral proteins, they also downregulate its production of native proteins using a special viral translation initiation factor (vIF4F), which has specificity to viral transcripts!
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Alexander J. Stein @ajstein.bsky.social · 14/02/2026
Some wasps harbour the genetic material of viruses in their genome, helping them use moth larvae as living incubators for their eggs: doi.org/10.1038/d415... >> Horizontal gene transfer isn't just human-made, also nature produces transgenic organisms! #GMO #Science
doi.org
Parasitic wasps use tamed virus to castrate caterpillars
A virus that became integrated into the wasp genome long ago is useful for subduing moth larvae.
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 07/02/2026
This interesting study concerns aging in WORMS 🪱. Why is it that only PLANT 🌱 researchers put their organisms’ names in paper titles? Gedankenexperiment: Who would NOT feel deceived if a plant aging paper did not mention plants in the title?
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Cell Biology J-Club @cellclub.bsky.social · 30/01/2026
Multiple protein structure alignment at scale with FoldMason | Science www.science.org/doi/10.1126/...
science.org
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
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Chenxin Li, PhD @chenxinli2.bsky.social · 24/01/2026
Rational improvement of pennycress using CRISPR. #PlantScience From: www.nature.com/articles/s41...
nature.com
Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing - Nature Plants
De novo domestication was performed on the brassica Thlaspi arvense (pennycress) by identifying and stacking CRISPR-induced mutations to create a new intermediate oilseed crop that can be grown in the...
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Yori Dola @gene-boy.bsky.social · 10/01/2026
I left Twitter when Musk started with the Nazi salutes. Twitter has steadily progressed to generating and distributing explicit images of children. Yet still, some friends and colleagues remain on the platform, seemingly unbothered (at least, not sufficiently). I wonder, what will it take?
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Yori Dola @gene-boy.bsky.social · 07/01/2026
I have long been skeptical of biostimulants as a broadly-usable product in Ag 🌱 🚜 Unfortunately, that seems to have been warranted 😬 The authors made a great effort, lots of work went into this!
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Yori Dola @gene-boy.bsky.social · 07/01/2026
Some colleagues and I just published a #PreprintReview of “The parasitic plant Cuscuta campestris selectively loads trans-species miRNAs onto host Argonautes, but not self Argonautes” 📜 Another output from the NBI's #PreprintPizzaParty 🍕🍕🍕
prereview.org
PREreview of “The parasitic plant Cuscuta campestris selectively loads trans -species miRNAs onto host Argonautes, but not self ...
Authored by Yordan Dolaptchiev, Karen Uchida, and 3 other authors
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c0nc0rdance @c0nc0rdance.bsky.social · 06/01/2026
I need a mood booster, let's talk about capybaras. Here's a capy demonstrating one of MANY ways they can move through the water: running along the bottom. They're 'semi-aquatic' mammals, just like hippos, seals & beavers. They LOVE water. (📷: Fernando Maidana)
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Thiago Carvalho @cyrilpedia.bsky.social · 04/01/2026
'Although AI is helping Science catch errors that can be corrected or elements that are missing from a paper but should be included, such as supporting code or raw data, its use and the evaluation of the output require more human effort, not less.' www.science.org/doi/10.1126/...
science.org
Resisting AI slop
It’s hard to talk about any topic in science or education today without the subject of artificial intelligence (AI) coming up—whether large language models should be allowed to aid in searching for a ...
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Jay Keche G. @caterpillar-coevo.bsky.social · 03/01/2026
It's only a war if its made in the War river valley, otherwise it's just a sparkling military operation
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Claudia Martinho @cssmartinho.bsky.social · 02/01/2026
Genome editing in brown algae! 🧬🪸🌿 Now out in Cell Reports Methods! Excited to share this highly efficient, transgene-free CRISPR–Cas genome editing protocol for brown algae, requiring no cloning and no specialized equipment. doi.org/10.1016/j.cr... #CRISPR #BrownAlgae @mpi-bio-fml.bsky.social
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Brian Naughton @btnaughton.bsky.social · 30/12/2025
Releasing alignism, a small tool that I have found useful for doing multiple sequence alignment in browser. hgbrian.github.io/alignism/ - The hard work was done by the awesome biowasm team! - Does tree building too - V fast compared to e.g., muscle on EBI - Not tested that much!
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Dr Darren Abbey @thebiologistisn.bsky.social · 29/12/2025
A few years ago, through luck and vibes, I managed to produce this blue colored bean variety. This was an early step in trying to answer the question, [paraphrased] "Why isn't blue as common as red in beans, even though they're both anthocyanins and the plant has the genes for both?"
Pint jar filled with blue dry beans.
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Ralph Hückelhoven @huckelhovenr.bsky.social · 28/12/2025
Important theoretical framework for NLR evolution. doi.org/10.32942/X2R...
doi.org
Towards a quantitative view of the NLR gene family 4evolution in the genome space
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Yori Dola @gene-boy.bsky.social · 23/12/2025
The recent attacks on Ukraine have got me worrying, like many Europeans. I find anxiety flourishes in the absence of action. If you support democracy and have the means, consider donating below. There is a pride in knowing your support is not limited to words/posts. u24.gov.ua
u24.gov.ua
UNITED24 - The initiative of the President of Ukraine
UNITED24 was launched by the President of Ukraine Volodymyr Zelenskyy as the main venue for collecting charitable donations in support of Ukraine. Funds will be transferred to the official accounts of...
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Bruno Ngou @brunongou.bsky.social · 22/12/2025
We wrote a review on the mᴏdular properties of plant cell-surface receptors, and how this knowledge can be used to reprogram and engineer them: www.sciencedirect.com/science/arti...
sciencedirect.com
A guide to designing cell-surface receptors in plants
Cell-surface receptors perceive environmental cues and trigger appropriate responses. In plants, these receptors comprise ectodomain, juxta-membrane, …
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