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Doryen Bubeck

@doryenbubeck.bsky.social
2.4K followers 747 following 12 posts

Professor of Structural Immunology, Director of Research Department of Life Sciences, Imperial College London

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Doryen Bubeck @doryenbubeck.bsky.social · 13/10/2025
This was me with my mom going for an @EMBO young investigator award interview 2 weeks after my son was born. Thank goodness for moms and a quick turn around at the passport office 😆
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Doryen Bubeck @doryenbubeck.bsky.social · 30/09/2025
Thanks @ccpem.bsky.social for an excellent workshop today showing @imperiallifesci.bsky.social what we can do with #doppio on our new computing cluster funded by @ukri.org
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Juha Huiskonen @juhahuiskonen.bsky.social · 08/07/2025
In our latest preprint on bioRxiv, we present the in situ structure of the human gap junction at 14 Å resolution using cryo-ET. The structure provides a blueprint for investigating how connexin regulation shapes intercellular communication in health and disease.
CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)
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Matt Higgins @parasitematt.bsky.social · 13/06/2025
Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!
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Imperial Life Sciences @imperiallifesci.bsky.social · 08/06/2025
Thank you everyone who sponsored the @doryenbubeck.bsky.social Bubeck lab to run the CRUK Pretty Muddy Race for Life. The team raised over £1200! #OurImperial fundraise.cancerresearchuk.org/page/doryens...
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CRUK Convergence Science Centre @crukconvergence.bsky.social · 02/06/2025
Join us for our next #ConvergingOnCancer seminar where we'll explore these topics with: ➡️Prof @doryenbubeck.bsky.social‬ (@imperialsci.bsky.social‬) ➡️Dr @claudioalfieri.bsky.social‬ (@icr.ac.uk‬ ) 📅 Thursday 5th June, 3-4pm 🖱️ For more information and how to register: bit.ly/3Z80SqS
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Kat Toropova @kattoropova.bsky.social · 28/05/2025
⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford. We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport. ❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬 30/5/25 ➡️ tinyurl.com/KToropovaPDRA
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Imperial Life Sciences @imperiallifesci.bsky.social · 24/05/2025
Still time to sponsor @doryenbubeck.bsky.social who ran the Pretty Muddy Race for Life for Cancer Research UK this weekend! Congrats Doryen! fundraise.cancerresearchuk.org/page/doryens...
fundraise.cancerresearchuk.org
Doryen's Race for Life
I haven't met a single person whose life has not been touch by cancer. The current statistic is that 1 in 2 people will be diagnosed with cancer in their lifetime. As a scientist I know the significan...
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Imperial Life Sciences @imperiallifesci.bsky.social · 15/05/2025
Exciting progress in drug discovery - a cross-disciplinary team including @doryenbubeck.bsky.social, Tate and Kawamura researchers have developed the first macrocyclic peptide inhibitors for CD59 — a tricky cell-surface receptor often hijacked by bacteria. www.imperial.ac.uk/news/263433/...
imperial.ac.uk
Macrocyclic peptide inhibitors for CD59 receptor | Imperial News | Imperial College London
A collaboration between the Tate, Bubeck and Kawamura groups has developed the first macrocyclic peptide inhibitors for cell-surface receptor CD59
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Kelly Nguyen @kellythd-nguyen.bsky.social · 16/04/2025
We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.
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Doryen Bubeck @doryenbubeck.bsky.social · 14/04/2025
Great day collecting cryo SIM data @diamondlightsource.bsky.social
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Doryen Bubeck @doryenbubeck.bsky.social · 08/04/2025
Honored to have been chosen for this year’s GlaxoSmithKline Award from @biochemsoc.bsky.social. A big thank you to lab members past and present @imperialsci.bsky.social and @erc.europa.eu @cruk-si.bsky.social @wellcometrust.bsky.social for supporting our work.
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Imperial Life Sciences @imperiallifesci.bsky.social · 19/03/2025
Did you miss the @doryenbubeck.bsky.social inaugural lecture last week or just fancy re-watching?! 😀 Join Doryen in the fascinating world of proteins, the "tiny machines" that drive cellular functions, using cryo electron microscopy. www.youtube.com/live/H14PeFt... #OurImperial
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Imperial Life Sciences @imperiallifesci.bsky.social · 17/03/2025
We're excited that Facilities Manager Sam Horrell has made it to the London Final of FameLab, a science outreach competition with 3 minutes to explain a scientific topic in an engaging way. The final is on 2 April and is free - please come & support Sam! www.eventbrite.co.uk/e/london-fam...
eventbrite.co.uk
London FameLab Final
Experience the excitement of the London FameLab Final! Enjoy engaging science talks as contestants compete for a place in the UK Final.
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Doryen Bubeck @doryenbubeck.bsky.social · 15/03/2025
www.youtube.com/watch?v=H14P...
youtube.com
Big questions, tiny machines
YouTube video by Imperial College London
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Alexey Amunts @amunts.bsky.social · 12/03/2025
Sad news about Karen Davies' passing. Karen was an inspiration in bioenergetics and cryoET. Her pioneering postdoctoral work on ATP synthase and respiratory supercomplexes marked turning points in the field. I created Scholar profile to acknowledge her contribution scholar.google.com/citations?hl...
scholar.google.com
Karen Davies
‪Formerly of Electron Bio-Imaging Centre, Diamond Light Source, United Kingdom‬ - ‪‪Cited by 2,887‬‬ - ‪cryo-EM‬ - ‪tomography‬ - ‪method development‬ - ‪bioenergetics‬
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Stephen Graham's Lab @atomicvirology.bsky.social · 12/03/2025
Great live demonstration of how election microscopy works, and the signal to noise challenge in atomic imaging, at @doryenbubeck.bsky.social's inaugural lecture #imperialinaugural
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Imperial Life Sciences @imperiallifesci.bsky.social · 12/03/2025
Amazing inaugural lecture tonight from @doryenbubeck.bsky.social Proteins scatter electrons, but the images are noisy...check out how an electron microscope works as showcased by our Head of Department @dandavis101.bsky.social 😄😃🔬
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Imperial Life Sciences @imperiallifesci.bsky.social · 12/03/2025
Thanks so much @doryenbubeck.bsky.social for an amazing inaugural lecture tonight, 'Big Questions, Tiny Machines' nothing short of inspiring for our packed audience! 👩‍🏫 #OurImperial Did you miss it?! No worries if so, as you can check out the recording below: www.youtube.com/live/H14PeFt...
youtube.com
Big questions, tiny machines
YouTube video by Imperial College London
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Stephen Curry @scurry.bsky.social · 12/03/2025
A highlight of Professor @doryenbubeck.bsky.social‘s inaugural lecture tonight was @dandavis101.bsky.social being pounded with electrons…
Dan, in white lab coat with a shield, sends of electrons being thrown at by an assembled mob of audience volunteers.
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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · 11/03/2025
🎉 And that’s a wrap! The Wellcome-MRC Cryo-EM in Structural Biology 2025 course in Leeds was a fantastic week of learning, hands-on training, and great discussions. Huge thanks to our amazing instructors, speakers & enthusiastic participants for making it such a success! #CryoEM
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Imperial Life Sciences @imperiallifesci.bsky.social · 17/02/2025
Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!! 📅 Wed, 12 March 2025 Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease. @doryenbubeck.bsky.social #OurImperial
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byrnelabicl.bsky.social @byrnelabicl.bsky.social · 04/02/2025
Really looking forward to this. Come along if you can!
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Imperial Science @imperialsci.bsky.social · 03/02/2025
🔬 Join us for Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines" @doryenbubeck.bsky.social @imperiallifesci.bsky.social 📅 Wed, 12 March 2025 Discover how structural biology has changed the game when studying proteins & their role in immune responses 👉 bit.ly/4aHdABe
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Martin Walsh @walshdls.bsky.social · 29/01/2025
1) We have an exciting job opportunity in correlative bioimaging at B24 at @diamondlightsource.bsky.social applying cryo soft x-ray microscopy (cryoSXT) and super-resolution 3D structured illumination fluorescence Microscopy (CryoSIM)
tinyurl.com
Beamline Scientist - 3D Correlative cryo-Bioimaging (11526)
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Tominaga K. (tomiken) @pacyc184.bsky.social · 15/01/2025
Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT | Nature Communications www.nature.com/articles/s41467-025-…
nature.com
Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT - Nature Communications
Outer membrane protein TraT protects bacteria from secondary F plasmid conjugation. Here, the authors report cryo-EM structure of decameric cork-like TraT and its evolutionary history as a chromosomal gene that has been incorporated into multiple plasmid families.
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Lori Passmore @lapassmore.bsky.social · 10/01/2025
Reminder that @arianebriegel.bsky.social compiled a nice list of women in #cryoEM . I often get asked to recommend people and this is a great place to start 😀 briegel-lab.org/women-in-cry...
briegel-lab.org
Women in CryoEM - Briegel Lab
Do you want to organise an event including cryoEM and need female speakers? We have a list for that!…
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Judi Allen @profjudiallen.bsky.social · 31/12/2024
Many Congratulations to Dan for a well-deserved MBE!! @dandavis101.bsky.social Read his books if you haven’t already. My favourite is the Beautiful Cure.
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Matt Higgins @parasitematt.bsky.social · 20/12/2024
Congratulations to Dr Richard Zhou! And thanks to his lovely examiners @doryenbubeck.bsky.social and Yvonne Jones for giving him a really engaging viva. Watch out for his nice paper, coming soon. A proud supervisor.
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Doryen Bubeck @doryenbubeck.bsky.social · 17/12/2024
Christmas lunch 2024
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Jez Carlton @jezcarlton.bsky.social · 16/12/2024
Okay, now onto membrane damage and repair! Dylan Noone (@doryenbubeck.bsky.social lab) tells us more about how CD59 inhibits the MAC to limit membrane damage, and @patrycja-kozik.bsky.social tells us about a fascinating role for endosomal permeabilisation in cross presentation of antigens! #UKMT2024
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Imperial Science @imperialsci.bsky.social · 13/12/2024
🥔 A new £5.9M study including @imperiallifesci.bsky.social's @tolgaboz.bsky.social and @doryenbubeck.bsky.social aims to unlock the mysteries of potato blight! This could pave the way to protecting global food security against devastating crop diseases www.imperial.ac.uk/news/259273/...
imperial.ac.uk
New study will peel away the secrets of potato blight | Imperial News | Imperial College London
A new study will aim to reveal the secrets of potato blight, a disease that threatens food production worldwide.
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Alessandro Costa @costalaboratory.bsky.social · 11/12/2024
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.
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Johanna Joyce @johannajoyce.bsky.social · 11/12/2024
#50ScientistsThatInspire 🧪 Christopher Barnes, a structural biologist investigating viral-host interactions, discusses the importance of #mentors "There are two things that I believe have the most impact on an individual’s success in science: mentorship & perseverance" @cobarnes27.bsky.social 🧵
cell.com
Structural biologist Christopher O. Barnes says equity and inclusion in science are not merely virtues but necessities
To push science forward, we need to foster an environment where people from diverse backgrounds, fields, and perspectives feel empowered, says Dr. Barnes.
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Imperial Life Sciences @imperiallifesci.bsky.social · 12/12/2024
#Pathogens are a huge threat to our crops, causing devastating disease such as the #potato blight. In this new £5.91 million study, Life Sciences researchers Prof Doryen Bubeck & Dr Tolga Bozkurt will work with partners to overcome this challenge. 🥔🧑‍🌾🧺🌾 www.imperial.ac.uk/news/259273/...
imperial.ac.uk
New study will peel away the secrets of potato blight | Imperial News | Imperial College London
A new study will aim to reveal the secrets of potato blight, a disease that threatens food production worldwide.
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Doryen Bubeck @doryenbubeck.bsky.social · 12/12/2024
Excited to announce the start of a new research direction in the lab using #cryoEM to tackle one of the biggest challenges in food production @tolgaboz.bsky.social @imperiallifesci.bsky.social @ukri.org www.imperial.ac.uk/news/259273/...
imperial.ac.uk
New study will peel away the secrets of potato blight | Imperial News | Imperial College London
A new study will aim to reveal the secrets of potato blight, a disease that threatens food production worldwide.
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Alessandro Costa @costalaboratory.bsky.social · 27/11/2024
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳 Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m
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Eugene Valkov @eugenevalkov.bsky.social · 27/11/2024
Cool biochem/cryoEM study
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Katie Downes @dr-downes.bsky.social · 26/11/2024
Latest paper from our lab out now! #TeamTomo #CryoET www.nature.com/articles/s41...
nature.com
Cryo-electron tomography reveals how COPII assembles on cargo-containing membranes - Nature Structural & Molecular Biology
The authors reconstituted coat protein complex II vesicles from native membranes and used cryo-electron tomography and subtomogram averaging to reveal the arrangement of inner and outer coat layers on...
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Neil Ranson @naranson.bsky.social · 18/11/2024
Hey Bluesky! For my first post thought I'd share this awesome movie made by Phopho Biomedical Animation for our recent paper on the folding of bacterial outer membrane proteins in Nature Comms: doi.org/10.1038/s414... #cryoEM #AstburyCentre
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Neil Ranson @naranson.bsky.social · 18/11/2024
I am about to be recruiting two post-docs to work on cryoEM and cryoET of amyloid aggregates... Anyone interested please drop me a line while the wheels of our HR department turn.............
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Susan Lea @smlea.bsky.social · 08/03/2024
Published today Steve and Justin’s story that finally reveals the basis for transmission of uni directional ion flow into bi-directional rotation of the bacterial flagellum doi.org/10.1038/s415...
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Basil Greber @bjgreber.bsky.social · 13/11/2024
Come work with us! Only a few days remaining to apply for the #cryoET / #CLEM facility scientist position at the @icrlondon.bsky.social! #cryoEM jobs.icr.ac.uk/vacancies/96...
jobs.icr.ac.uk
Higher Scientific Officer / Senior Scientific Officer – CLEM & cryoET scientist in Chelsea | The Institute of Cancer Research
View details and apply for this Higher Scientific Officer / Senior Scientific Officer – CLEM & cryoET scientist vacancy in Chelsea . Salary : Commencement on the salary range is subject to comp...
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Doryen Bubeck @doryenbubeck.bsky.social · 12/11/2024
Looking forward to a new platform for science! Help me build my #cryoEM #STEM network after jumping ship.
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