We generated a comprehensive multi-omic atlas of the human gingiva, showing that the tooth-associated epithelium maintains a unique, pre-inflammatory state even in health. Signals from the epithelium ...

Schmiechen et al. found that variants of PDA that escaped following PD-L1 blockade showed epigenetic silencing of Tap1 expression, which induced loss of IFNγ-inducible MHC-I and reduced tumor cell killing mediated by CD8+ T cell. Escape variants also had an increased capacity for metastasis, which was promoted by Tregs and their suppressive effect on conventional CD4+ T cells. Combination strategies involving restoring IFNγ-inducible MHC-I, targeting Tregs, and enhancing Tconv enabled more effective cancer immunotherapy, suggesting potentially targetable mechanisms to enhance immunotherapy in PDA.

Maurice et al. examine how cytokines regulate antigen-independent activation of memory CD8+ T cells. They show that IL-4 signaling changes the quality of the bystander T cell response by antagonizing ...

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Adoptive cell therapy (ACT) has shown remarkable success in the treatment of some malignancies, particularly leukemia. However, there are multiple factors that limit the durability of ACT in solid tum...

The Highly Cited Researchers 2025 list identifies and celebrates individuals who have demonstrated significant and broad influence in their fields of research. Through rigorous selection criteria and ...

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We have recently witnessed a revolution in our ability to modulate the immune system to increase the recognition and destruction of infectious agents and cancer cells, as well as to selectively dampen...

This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

Abstract. Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to therapy including immune checkpoint blockade (ICB). We previously show

AAI Member Carla Rothlin was recently elected vice-president of the International Union of Immunological Societies

Communications Biology - Transcriptional analysis of lipid associated macrophages across chronic inflammatory diseases and tissues reveals shared and tissue-restricted gene expression programs.

Dr. Stephen Jameson is the President of the American Association of Immunologists, and LMP Professor and Harry Kay Chairman's Fund Professor in Experimental Pathology at the University of Minnesota Tw...

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