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Nicolas Buchon

@nicobuchon.bsky.social

125 followers 151 following 2 posts

Associate Prof at Cornell interested in Host/microbe interactions, Gut Homeostasis, Stem Cell Biology, Innate Immunity, Vector Biology etc. buchonlab.com/index.html

Posts Replies Media

Nicolas Buchon @nicobuchon.bsky.social · 31/07/2026

Interested in #mosquito immunity, blood feeding & vector competence? @georgesaman.bsky.social & I have a new review in @frontiersin.bsky.social on how the blood meal, microbiota & endocrine signals shape immune function and pathogen transmission. 🦟 #VectorBiology www.frontiersin.org/journals/imm...

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Nicolas Buchon @nicobuchon.bsky.social · 19/09/2025

Our new study is out in Cell Reports! We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...

cell.com

Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover

Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that is activated by infection independently of DNA damage. This pathway promotes enterocyte loss, cytokine production, and...

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Reposted by Nicolas Buchon

David Duneau @dduneau.bsky.social · 06/06/2025

It is difficult to interpret single #pathogen burden during #infection. It is hard to untangle default in resistance and tolerance to explain #susceptibility. We help making sense of with-host dynamics and give tools to study infection, especially in #Drosophila. elifesciences.org/articles/104...

elifesciences.org

A within-host infection model to explore tolerance and resistance

A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of ...

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Reposted by Nicolas Buchon

Development @dev-journal.bsky.social · 19/05/2025

In preprints: are microbes the architects of animal bodies? Alessandro Bonfini, Peter Nagy and @nicobuchon.bsky.social @cornellentomology.bsky.social‬ discuss a recent #preprint from Jinru He, Thomas Bosch and colleagues: journals.biologists.com/dev/article/...

In preprints: a new preprint curation initiative from Development

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