iiinova — where your digital self keeps evolving

Reposted by David Duneau

Junior European Drosophila Investigators @fly-jedi.bsky.social · 14/09/2026

Dear #Drosophila and #NewPI community, the mentee survey for this great mentorship program is still open!

Reposted by David Duneau

TK (Takashi DY) Kozai @bioniclab.bsky.social · 26/06/2026

🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5

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David Duneau @dduneau.bsky.social · 17/06/2026

Interesting resource for those starting with #Drosophila research (set of videos by Bruno Lemaitre) youtu.be/aUewlFU-6rw?...

youtu.be

Drosophila Genetics 1 Basic Knowledge edX compressed

YouTube video by Bruno Lemaitre

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Mark A. Hanson @hansonmark.bsky.social · 28/05/2026

+15k signatures now in just over one day. Britons now favour rejoining the EU with a strong majority (+21). At 100k, it became "considered for debate in parliament." This is worth sharing. Tell parliament in clear terms what they're debating, and for who.

From Yougov tracker: public support for Britain rejoining the EU IS AT 56 support, 35 oppose. A net support of +21.

Among those who voted "Leave" in 2016, 22% would now vote "Remain."

They're vewy sowwy.

Screenshot of the UK gov petition update that this petition passed 100k signatures in on May 27, 2026.

While the petition started 6 months ago, it has only recently garnered attention. On May 26th, it was near ~90k signatures.

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Reposted by David Duneau

Jimmy Kimmel @jimmykimmel.com · 21/05/2026

Tonight we congratulate our friend Stephen Colbert and his writers, staff and crew for eleven years of excellence. Watch Colbert’s finale tonight, and then never watch CBS again.

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Reposted by David Duneau

Mark Peifer (He, him) @peiferlabunc.bsky.social · 13/05/2026

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

https://www.nature.com/articles/s41586-025-10004-2
Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC

U. Sahin, M. Schmidt, E. Derhovanessian, A. Cortini, I. Vogler, T. Omokoko, E. Godehardt, S. Attig, S. Newrzela, J. Grützner, N. Bidmon, S. Bolte, S. Brachtendorf, T. Stuhlmann, D. Langer, D. Brüne, J. Blake, A. Feldner, H. Lindman, A. Schneeweiss, M. Eichbaum & Ö. Türeci
Triple-negative breast cancer (TNBC) is frequently associated with metastatic relapse, even at an early stage1. Here we assessed an individualized neoantigen mRNA vaccine in 14 patients with TNBC following surgery and after neoadjuvant or adjuvant therapy. In peripheral blood of nearly all patients, high-magnitude, vaccine-induced, mostly de novo T cell responses to multiple neoantigens were detected that remained functional for several years. Characterization of individual patients revealed that a large proportion of these T cells developed into two subsets: a late-differentiated phenotype with markers indicative of ‘ready-to-act’ cytotoxic effector T cells, and T cells with a stem cell-like memory phenotype. Eleven patients remained relapse-free for up to six years post-vaccination. Recurrence occurred in three patients: the individual with the weakest vaccine-induced T cell response relapsed, but achieved complete remission on subsequent anti-PD-1 therapy; another patient had a tumour with low major histocompatibility complex (MHC) class I expression with MHC class I-deficient cells growing out under vaccination; and the third patient was BRCA-positive and had a recurrence from a genetically distinct primary tumour. These findings demonstrate the feasibility of individualized RNA vaccines in TNBC, document persistence of vaccine-induced, functional neoantigen-specific T cells and provide insights into possible immune escape mechanisms that will guide future approaches.

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Reposted by David Duneau

The Dobson Family and Colin the Dalek @dobbersw.bsky.social · 08/05/2026

I still love the theory a Year 6 child proposed to me that David Attenborough is actually God and he got fed up with people not noticing the amazing things he'd created, so he made documentaries to show off.

David Attenborough and one of his creations.

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David Duneau @dduneau.bsky.social · 06/05/2026

I am. ery happy to join the JEDI meeting in Portugal for the first time as #newPI. Come join us!

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Reposted by David Duneau

Flo Débarre @flodebarre.eurosky.social · 05/05/2026

In this (very niche) post, I explain how I FOIA'd NIH to demonstrate that NCBI staff did not alter the metadata of a coronavirus sequence dataset. Come the emails, stay for the pangolins? (also works the other way round (-:) #covidorigin

pandemonium.hypotheses.org

The pangolin sub-subplot

This is the story of a coincidence: some lab leakers managed to make sequence data of pangolin viruses public again the same day that Jesse Bloom was submitting a preprint highlighting their absence. ...

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Alfonso Martinez Arias @amartinezarias.bsky.social · 29/04/2026

This is definitely something that should be discussed before implementation. Read and provide feedback. What we need is more funding, not more restrictions. A particularly bad move for Starting, and specially, Consolidator stage.

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Laura Ross @laurarossevo.bsky.social · 27/04/2026

Did you know that many organisms delete parts of their genome during development? To know more please join us at the Roscoff meeting on "Mechanistic and Evolutionary Basis of Programmed DNA Elimination" Sep21- 25, 2026. Please share! cjm.sb-roscoff.fr/en/conferenc...

cjm.sb-roscoff.fr

The mechanistic and evolutionary basis of programmed DNA elimination | CNRS - Conférences Jacques Monod (CJM)

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Reposted by David Duneau

Genome Biology and Evolution @genomebiolevol.bsky.social · 20/04/2026

Tsang et al. used four species of Drosophila to investigate how climate affects gene expression in different sexes of insects, showing that protein-coding genes and microRNAs have undergone different selection between sexes. 🔗 doi.org/10.1093/gbe/... #genome #evolution #drosophila

doi.org

Response of Protein Coding Genes and microRNAs to Temperature Changes in Four Species of Drosophilids

Abstract. Insects are the most abundant described living animals in the world, and they play important roles in the environment and in human society. Clima

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Reposted by David Duneau

PLOS Biology @plosbiology.org · 20/04/2026

The #circadian clock & cellular #metabolism: @drummonk.bsky.social & @joanna-chiu.bsky.social explore a @plosbiology.org study showing how #glucose #metabolism changes during the day in #Drosophila and how it is disrupted in clock & sleep mutants 🧪 Paper: plos.io/3Olm1M1 Primer: plos.io/4sUov2g

Clock-gated morning rush hour of glucose utilization depicted as highway traffic. In the morning (left), clock-controlled food intake at dawn results in high glucose concentration in Drosophila body tissues, analogous to higher number of vehicles on the highway. This increased “traffic flow”, defined by the total number of vehicles passing a given point in a given time, is aided by the opening of the “7AM-11AM only” lanes that are gated by the circadian clock. This is analogous to higher metabolic flux in the morning hours in fly tissues. In other times of the daily cycle (right), both glucose concentration (number of cars) and pathway flux (traffic flow) are low. Vehicle icons were generated by authors using Google’s Nano Banana 2 from the prompts such as “create a top-view of a car icon in white background”, February 16, 2026.

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Reposted by David Duneau

Sunkissed Peaks @sunkissedpeaks.bsky.social · 22/04/2026

Morning friends. There are still those amongst us that need to wake up.

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Reposted by David Duneau

Meet Zandawala @zandawala.bsky.social · 20/04/2026

Can a single brain cell decide whether to eat or not? 🧠🪰 Turns out... yes. And we found it in the fruit fly. A pair of neurons called SELKs (subesophageal leucokinin neurons) can drive feeding behavior in both directions. They promote it or suppress it. Here's how: 🧵

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Reposted by David Duneau

Mathilde Larrère @mathildelarrere.bsky.social · 20/04/2026

Un nouveau site pour les 30 ans et un appel ; "Transformer les médias, une urgence démocratique !" Bravo et merci à @acrimed.bsky.social

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Reposted by David Duneau

Barbara Tschirren @btschirren.bsky.social · 15/04/2026

New paper out: Artificial selection for increased reproductive effort accelerates actuarial senescence and reduces lifespan in a precocial bird url: royalsocietypublishing.org/rspb/article... @uniexecec.bsky.social @erikpostma.bsky.social @joelpick.bsky.social y.social @oscarvedder.bsky.social

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David Duneau @dduneau.bsky.social · 15/04/2026

Very nice read explaining why if your variables that you want to correlate are measured with error, a simple correlation underestimates the true relationship, and you need to use methods that account for that error, rather than simply correlating summary statistics like line means.

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Reposted by David Duneau

Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026

Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1

nature.com

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism

In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

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David Duneau @dduneau.bsky.social · 13/04/2026

If you know about @peercommunityin.bsky.social, the future of scientific publishing, you should take this short survey. If you don’t know about it, you absolute should read about it, and take the survey. form.typeform.com/to/CO4KpWgi

form.typeform.com

PCI and PCJ survey

Turn data collection into an experience with Typeform. Create beautiful online forms, surveys, quizzes, and so much more. Try it for FREE.

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Reposted by David Duneau

Russell England @russellengland.bsky.social · 12/04/2026

France is switching from Microsoft to Linux "We must become less reliant on American tools and regain control of our digital destiny. We can no longer accept that our data, our infrastructure, our strategic decisions depend on solutions whose rules, pricing, evolution, and risks we do not control."

numerique.gouv.fr

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Massimo (mirror) @rainmaker1973-m.bsky.social · 11/04/2026

A mother Pilot Whale carries the body of her dead baby. When a mother loses her baby, she carries it in her mouth for weeks, until it decomposes. This mourning process is known as requiem. [📹 Felipe Ravina Olivares] Original post

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Itai Yanai @itaiyanai.bsky.social · 12/04/2026

There's a strange myth about science: that theory comes first, and that data cannot show anything new. But anyone who's ever done science knows the truth that there's a long conversation between data & hypotheses. Back & forth.. until the discovery. And if you think about it, it has to be this way!

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Thiago Carvalho @cyrilpedia.bsky.social · 11/04/2026

Buckle up 'So let’s finally talk about peptides. And I don’t mean peptides as chemists and biologists understand them (short chains of amino acids) I mean “Peptides!”, the hot new wonder drugs that you can order by mail. Oh man.' www.science.org/content/blog...

science.org

Ah, Peptides. Where to Begin?

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Patrícia Beldade @pbeldade.bsky.social · 09/04/2026

Posição para Professor Auxiliar OU em História e Filosofia da Ciência OU em Genética 🧬 na FCUL a aceitar candidaturas até 12 de Maio. Mais informação aqui: arquivo.ciencias.ulisboa.pt/concursos?id...

arquivo.ciencias.ulisboa.pt

Concursos | Faculdade de Ciências da Universidade de Lisboa

Faculdade de Ciências da Universidade de Lisboa Campo Grande 1749-016 Lisboa Portugal T (+351) 217 500 000 info@ciencias.ulisboa.pt

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Reposted by David Duneau

Patrícia Beldade @pbeldade.bsky.social · 09/04/2026

Posição para Professor Auxiliar OU em História e Filosofia da Ciência OU em Biologia Evolutiva na FCUL a aceitar candidaturas até 12 de Maio. Mais informação aqui: arquivo.ciencias.ulisboa.pt/concursos?id...

arquivo.ciencias.ulisboa.pt

Concursos | Faculdade de Ciências da Universidade de Lisboa

Faculdade de Ciências da Universidade de Lisboa Campo Grande 1749-016 Lisboa Portugal T (+351) 217 500 000 info@ciencias.ulisboa.pt

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David Duneau @dduneau.bsky.social · 10/04/2026

Agreed, although it should not take crises to remember that there are people behind papers/grants.

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Kristen Boyle, PhD @kristenboyle.bsky.social · 10/04/2026

Many talk about #obesity as if it is something we can fully control, but this ignores our underlying biology. 🧪 Two papers came out this week highlighting this point: First, genetics impact GLP1 receptor agonist efficacy. www.nature.com/articles/s41...

nature.com

Genetic predictors of GLP1 receptor agonist weight loss and side effects - Nature

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

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David Duneau @dduneau.bsky.social · 09/04/2026

What!? They close the US forest services?

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 09/04/2026

Comment donc? Plus de salaire permet d'avoir plus de pouvoir d'achat? Quelle surprise...

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Mark A. Hanson @hansonmark.bsky.social · 04/04/2026

Excellent move by Cancer Research UK to cease funding Gold OA if it's just going to contribute to hybrid journal growth. Green OA exists in numerous forms for free. When funders throw their weight around, researchers will follow their lead. Well done @cancerresearchuk.org !

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Mark A. Hanson @hansonmark.bsky.social · 01/04/2026

www.sciencedirect.com/science/arti... Nice review by Talia Akoh-Arrey and John Brooks. But it also made me appreciate the Current Opinions format with these 'highlighted' papers. Through them, my attention was drawn to: www.nature.com/articles/s41... ^^ and this is a really cool study! 1/4

sciencedirect.com

Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity

Antimicrobial peptides and proteins (AMPs) function as molecular rheostats of host–microbe interactions and cell-intrinsic defense. Rather than being …

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Nathan Woodling @nathanwoodling.bsky.social · 26/03/2026

Can we predict health, Or when flies drop like fall leaves? Yes, chemotypes can! www.biorxiv.org/content/10.6... #Drosophila #AgingResearch #sciku @thescikuproject.bsky.social

biorxiv.org

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Genome Biology and Evolution @genomebiolevol.bsky.social · 26/03/2026

Creasey, Petrov & Tauber analyze the evolution of 11 core clock proteins across 65 Drosophila species, finding that the circadian clock network does not impose strong constraints on the evolution of its components. 🔗 doi.org/10.1093/gbe/evag061 #genome #evolution #drosophila

doi.org

The Evolutionary Flexibility of the Drosophila Circadian Clock: Network Constraints or Adaptive Freedom?

Abstract. The study of network evolution is critical to understanding how complex biological processes arise and adapt over time. Protein networks, compose

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Jen Perry @jennyperry.bsky.social · 26/03/2026

DNA barcoding question: does anyone know of a facility that's lower cost than the Canadian Centre for DNA Barcoding ?

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Maryanne Chisholm 🌊 💙 @maryannechisholm.bsky.social · 25/03/2026

A view of the night sky from Mars. (Yes, really)

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Harkthorn @harkthorn.bsky.social · 24/03/2026

Raven, in ballpoint pen and Microns -3365 🎨🐡🪶 #art

A black ballpoint and black Micron pen sketch of a cawing raven from the neck up, viewed from the side and facing to the right of the image

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Renata C. Matos @renatafcmatos.bsky.social · 21/03/2026

New paper out! 🎉 How do beneficial bacteria tune their cell surface to impact host physiology? We explored this question in Lactiplantibacillus plantarum. www.biorxiv.org/content/10.6...

biorxiv.org

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Paolo Crosetto @paolocrosetto.bsky.social · 19/03/2026

🚨Today 4pm CET🚨 PCI Webinar: The Drain of Scientific Publishing: why publishing is becoming a burden for science and how to fix it An overview talk based on three papers on #ScientificPublishing, where it stands & how to fix it. Plus dad jokes and bad acronyms. peercommunityin.org/pci-webinar-...

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Alt National Park Service @altnps.bsky.social · 19/03/2026

Clever. These are popping up all across the USA.

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SORTEE @sortee.bsky.social · 15/03/2026

The SORTEE guidelines for data and code quality control in ecology and evolutionary biology are now published in the Peer Community Journal! 🔗 peercommunityjournal.org/articles/10....

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Kevin Cariou @cariouk.bsky.social · 19/03/2026

1 min de silence pour un nazi vs. 4 ans de silence pour une victime...

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Gaza Freedom Flotilla Coalition @freedomflotilla.bsky.social · 18/03/2026

We are preparing the largest flotilla to Gaza in history. In a coordinated act of civil resistance, a global alliance will sail to break Israel’s illegal siege. This is more than a flotilla - it is a global uprising of conscience. Together we will #BreakTheSiege ! freedomflotilla.org/2026/03/18/j...

freedomflotilla.org

Joining Forces to Launch the Largest Flotilla Yet to Break Israel's Illegal Blockade on Gaza - Freedom Flotilla

The Global Sumud Flotilla, Global Freedom and Sumud Flotilla, Thousand Madleens to Gaza, and the Freedom Flotilla Coalition have joined forces to organize the largest flotilla to break Israel’s illega...

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