iiinova — where your digital self keeps evolving

Joris Deelen @jorisdeelen.bsky.social · 27/08/2026

Happy to share our new methods paper in which we developed a mortality-informed weighted Pace of Aging based on longitudinal data from the Swedish Adoption/Twin Study of Aging! 🧪 academic.oup.com/biomedgeront...

academic.oup.com

A generalized approach for estimating the pace of aging

AbstractBACKGROUND. Quantifying the rate of aging is essential for understanding age-related physiological decline and predicting late-life outcomes. The P

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British Society for Research on Ageing @bsrageing.bsky.social · 08/07/2026

Did you know that both DuSRA and @americanaging.bsky.social members are eligible to membership rates for BSRA’s Annual Scientific Meeting? The BSRA's 75th annual meeting looking like a great one! See you there DuSRA & AGE members! 9-11 Sept Oxford bsra.org.uk/events/75th-... #BSRA2026

bsra.org.uk

75th Annual Scientific Meeting of the BSRA (2026): The Biology of Ageing - BSRA

BRITAIN’S LEADING AGEING RESEARCH CONFERENCE In 2026, the BSRA is pleased to host its 75th Annual Scientific Meeting on the Biology of Ageing at the University of Oxford between 9th and 11th September...

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Joris Deelen @jorisdeelen.bsky.social · 12/06/2026

I am very proud of @maraneuerburg.bsky.social with her excellent PhD defense today! Now up to the next adventure!

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Der Code des Lebens @dercodedeslebens.bsky.social · 02/06/2026

📣 Neue Podcast-Folge 📣 Prof. Dr. Joris Deelen erzählt, warum manche Menschen über 100 Jahre alt werden und was uns die Langlebigkeits-Gene APOE und FOXO3 über das Altern verraten. 🎧 Hier gehts zur Folge: codedeslebens.podigee.io/55-langlebig... #Genetik #Forschung #Podcast #Wissenschaft #GHGA

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Joris Deelen @jorisdeelen.bsky.social · 29/05/2026

I am very happy to present you the latest preprint from my group at the @mpiage.bsky.social, which is the main outcome of the PhD project of Mara Neuerburg! 🧪🧬

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Joris Deelen @jorisdeelen.bsky.social · 15/05/2026

🚨Excited to share our new medRxiv preprint spearheaded by Mengle Zhu in which we provide novel mechanistic insights into the biology of familial longevity and cardiometabolic resilience using metabolomic and proteomic profiling!🚨 @molepi.bsky.social 🧪 www.medrxiv.org/content/10.6...

medrxiv.org

Multi-omics integration identifies metabolic and inflammatory pathways underlying familial longevity

Familial longevity, quantified using the Longevity Relatives Count (LRC) score indicating the proportion of ancestral long-lived family members, associates with a pronounced 13 years delayed onset of ...

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Jinte Middeldorp, PhD @jinteneuro.bsky.social · 01/05/2026

I’m hiring! We have a position for a scientist in our department Neurobiology & Aging. Check out the vacancy in Dutch & English in the links below 🧠

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Cologne Graduate School of Ageing Research @cga-age.bsky.social · 09/04/2026

🚨 Scholarship Alert! 🚨 🧬👩🏽‍🔬 Pursue your Master studies in Biology or Biochemistry in Cologne at @unicologne.bsky.social and get full funding with our CGA Master Fellowship programme.💰 📅 Apply by July 15! 🔗 Learn more: www.ageing-grad-school.de/master/maste...

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Joris Deelen @jorisdeelen.bsky.social · 02/04/2026

🚨I am happy to share our new paper in collaboration with @haggsara.bsky.social, spearheaded by Larissa Smulders 🚨 We provide further evidence that MetaboHealth is moderately heritable (40%) and is likely modifiable through lifestyle, e.g., smoking cessation. 🧪🚭 link.springer.com/article/10.1...

link.springer.com

The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins - GeroScience

The MetaboHealth score, a metabolomics-based biomarker trained on mortality, is associated with ageing-related phenotypes and morbidity, but its heritable component is still uncertain. Understanding g...

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Joris Deelen @jorisdeelen.bsky.social · 02/04/2026

link.springer.com

The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins - GeroScience

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CECAD Cologne @cecad.bsky.social · 01/04/2026

📣#CECAD will host two exciting conferences 📆 11th - 14th October 2026 15th AHA Conference - “From mechanisms of age-associated diseases to healthy aging” uni.koeln/7X2K8 📆 14th - 16th October 2026 1stEFAR Conference - “On the Biology of Aging” uni.koeln/YGPMA 👉 Submit abstracts by May 31st

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medRxivpreprint @medrxivpreprint.bsky.social · 17/02/2026

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk www.medrxiv.org/content/10.64898/20…

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Joris Deelen @jorisdeelen.bsky.social · 17/02/2026

What started as a student project from Gabriela Natalle Lopes together with Niels vd Berg has now become a fleshed out preprint in which we present Personal-MetaboHealth, a personalised version of MetaboHealth based on clinically validated metabolic biomarkers. 🧪 www.medrxiv.org/content/10.6...

medrxiv.org

Personal-MetaboHealth, an actionable health check in middle age, is improved by an effective lifestyle intervention in those at risk

The biomarker MetaboHealth represents a novel indicator of overall health in middle age and may potentially be suitable as actionable health check in prevention strategies. MetaboHealth is a blood-bas...

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Eric Topol @erictopol.bsky.social · 29/01/2026

🆕 @science.org Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors science.org/doi/10.1126/...

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Aging Science News @agingbiology.bsky.social · 21/01/2026

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families www.biorxiv.org/content/10.6...

biorxiv.org

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Leef als een naakte molrat @naaktemolratpod.bsky.social · 10/01/2026

Wat is de ideale methode als je wil beginnen met vasten? Zo pakken deze experts het aan. Voor meer tips, luister naar aflevering 3 van Leef als een Naakte Molrat: Spotify: lnkd.in/eyGeyybx Apple Podcasts: lnkd.in/e_JwiYvh #fasting #vasten #gezondheid #afvallen #wetenschap

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Joris Deelen @jorisdeelen.bsky.social · 09/01/2026

Was erg leuk om bij te dragen aan de @naaktemolratpod.bsky.social podcast serie over veroudering en vasten van Leon Doedens!

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delladavid-lab.bsky.social @delladavid-lab.bsky.social · 05/01/2026

🚨 Deadline Extended! 🙏 RT: Postdoc opening @ Babraham Institute, Cambridge to study extracellular #proteostasis and #aging. If you have #biochemistry expertise and want to join a world-class research environment, apply now! ✅ Global Talent Visa covered 📅 Apply by 09.01.26 👉 tinyurl.com/38rn6czz

tinyurl.com

hireful.

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Leef als een naakte molrat @naaktemolratpod.bsky.social · 31/12/2025

Goede voornemens voor 2026? Luister vanaf 2 januari naar Leef als een Naakte Molrat voor de laatste lifestylehacks uit de wetenschap over voeding, vasten, sport en mentale gezondheid. #podcast #lifehack #health #nutrition #fasting #fitness #mentalhealth

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Daniel Promislow @dpromislow.bsky.social · 16/12/2025

Interested in metabolomics/systems biology and aging in Drosophila? We have a post-doc opening! And of course, there will be plenty of opportunities for side projects on the @dogagingproject.bsky.social. 🐶 promislowlab.org/wp-content/u...

promislowlab.org

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delladavid-lab.bsky.social @delladavid-lab.bsky.social · 16/12/2025

🔬#Postdoc position available: We are looking for new lab member to join our team working on Protein #Aggregation and #Ageing in Cambridge. Please spread the word. tinyurl.com/38rn6czz

tinyurl.com

hireful.

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Joris Deelen @jorisdeelen.bsky.social · 09/12/2025

This includes a variant in cGAS, for which we subsequently showed it leads to a reduced function of the protein in cell lines from both humans and mice, which nicely complements earlier work on this protein in animal models. @molepi.bsky.social @marianbeekman.bsky.social @antebilab.bsky.social 🧬🧪

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Joris Deelen @jorisdeelen.bsky.social · 09/12/2025

🚨Proud to present the latest preprint from our group, spearheaded by Pasquale Putter and the culmination of many years of work on the Leiden Longevity Study, in which we used multigenerational long-lived families to identify novel rare protein-altering genetic variants linked to ancestral longevity.

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Joris Deelen @jorisdeelen.bsky.social · 09/12/2025

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Pedro S. B. Ferreira @pferreira.bsky.social · 08/12/2025

Key takeaway: Absence of CAD disease risk alleles is one key-feature linked to longevity and alleles linked to cholesterol metabolism are a key component in healthy aging trajectories. @jorisdeelen.bsky.social @marianbeekman.bsky.social

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Daniel Promislow @dpromislow.bsky.social · 27/11/2025

I'm very happy to see this paper now out. We used early-life climbing ability to separate genetically identical short-lived and long-lived sub-cohorts of fruit flies, and to identify metabolites and metabolite modules that predict longevity. onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

Early‐Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies

Isogenic Drosophila melanogaster vary greatly in longevity. Fractionation of an isogenic cohort based on climbing behavior early in life stratifies variation in the metabolome, longevity and mortalit...

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Nathan Woodling @nathanwoodling.bsky.social · 24/11/2025

My lab is associated with two fantastic project opportunities - one on circadian genes led by Matt Jones and one on inflammation in ageing led by Chris Mahony - which you can find in the 'Fundamentals of Life' theme at the link above.

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Dr. Rachel Lippert @rachellippert.bsky.social · 22/11/2025

Calling on my #science network! TeamNDF is #hiring a postdoc to start in 2026! Are you fascinated by metabolism and the brain? Do you want to dig into life long impacts and the molecular cause? Learn more about the team and our research here: www.dife.de/en/research/... Please share! 🧠 🍔 💉

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Joao Pedro Magalhaes @jpsenescence.bsky.social · 09/11/2025

I'm delighted to share our curated list of 100 open problems in ageing science. This represents a collective, systematic effort to map the key challenges and knowledge gaps across biogerontology and offers a roadmap to guide future progress in geroscience. link.springer.com/article/10.1...

link.springer.com

Open problems in ageing science: a roadmap for biogerontology - GeroScience

The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...

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British Society for Research on Ageing @bsrageing.bsky.social · 08/11/2025

📰Weekend read! BSRA & Dutch Society for Research on Ageing sign collaboration agreement of 1. Mutural speaker exchange 2. Reciprocal meeting benefits 3. Joint policy work 4. Joint initiatives 5. Future plans, watch this space... Read more - bsra.org.uk/dusra-collab...

bsra.org.uk

Dutch Society for Research on Ageing and BSRA sign collaboration agreement - BSRA

Speaking at the launch of this collaboration between the British Society for Research on Ageing (BSRA) and the Dutch Society for Research on Ageing (DuSRA), leaders from both societies outlined their ...

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Joris Deelen @jorisdeelen.bsky.social · 23/10/2025

Back again after some inspiring trips to both the TWIN4EarLiStAge HorizonEU Twinning Project summer school in Heraklion and the Biomarkers of Aging Consortium meeting in Boston. Great to see so many young scientists getting interested in ageing research!

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Joao Pedro Magalhaes @jpsenescence.bsky.social · 19/10/2025

PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI. Applications are open to UK and international students. Deadline: 27 November 2025. www.findaphd.com/phds/project...

findaphd.com

Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham on FindAPhD.com

PhD Project - Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham, listed on FindAPhD.com

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Joris Deelen @jorisdeelen.bsky.social · 27/09/2025

And that was the end of part 2, an inspiring G-JAM conference in Jena with many exciting talks! Next up the TWIN4EarLiStAge HorizonEU Twinning Project Training Course in the Biology of Aging in Crete and the Biomarkers of Aging Consortium meeting in Boston!

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Adam Rutherford @adamrutherford.bsky.social · 24/09/2025

Phenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.

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delladavid-lab.bsky.social @delladavid-lab.bsky.social · 19/09/2025

🔬We have a fully funded Cambridge Biosciences DTP PhD postion to study #Proteostasis and #Aging in colloboration with @jrkumita.bsky.social @Pharmacology. Details on the project ▶️https://tinyurl.com/2zhkjjhs + bbsrcdtp.lifesci.cam.ac.uk/how-apply . Please RT.

tinyurl.com

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Joris Deelen @jorisdeelen.bsky.social · 13/09/2025

Great to see this paper by Daniele Bizzarri now published in Immunity & Ageing! Here we show that a higher MetaboHealth score is associated with increased inflammatory/immune related proteins and decreased cholesterol transport related proteins. 🧪 immunityageing.biomedcentral.com/articles/10....

immunityageing.biomedcentral.com

Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport - Immunity & Ageing

The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth...

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Stephanie A. Fernandes @stephalcantara.bsky.social · 11/09/2025

My new lab at the MPI Age is looking for a postdoc in skeletal muscle cell and molecular biology! If you’re a curious and motivated scientist and would like to apply, check the details below:

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Joris Deelen @jorisdeelen.bsky.social · 08/09/2025

Conference season has officially started! I had a great time in Berlin last week @ComLab10 organised by the Alexander von Humboldt Foundation where I talked about our work on the genetics of human longevity. It was an inspiring meeting and I was really impressed by the pitches from the participants!

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Trentini Lab @trentini-lab.bsky.social · 01/08/2025

🚨 Happy to share our first pre-print 🎉 on the causes of ribosome-associated degradation of CFTR and other transmembrane proteins. We explore how protein folding, ER insertion, and elongation dynamics influence translation arrests in this new class of RQC targets.👇 www.biorxiv.org/content/10.1...

biorxiv.org

Principles of ribosome-associated protein quality control during the synthesis of CFTR

Prolonged translational arrests caused by defective mRNAs activate the ribosome-associated protein quality control (RQC) pathway, which marks harmful incomplete proteins for degradation. Multipass tra...

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Sophie Steculorum @sophiesteculorum.bsky.social · 29/07/2025

Grateful to @maxplanck.de ‬for featuring our recent paper in their amazing new video! 🎥🌟 Thank you for the wonderful spotlight on our work! 🙌😄

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Joao Pedro Magalhaes @jpsenescence.bsky.social · 28/07/2025

New preprint with our list of 100 open problems in ageing science. Our curated list captures both long-standing fundamental questions and emerging research frontiers. A massive team effort by >30 researchers from many disciplines in biogerontology. arxiv.org/abs/2507.18602

arxiv.org

Open problems in ageing science: A roadmap for biogerontology

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