This study reports that chronic exposure to microplastic and nanoplastic particles differentially affects Kupffer cells, which impairs their function and has consequences on both liver and systemic metabolism.

Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...

Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

How did modernizing cheesemaking change the microbes inside the cheese? By sequencing preserved traditional Alpine cheese wheels spanning 142 years from a single Alpine dairy, Somerville et al. trace ...

Fibrosis is a major contributor to disease and mortality yet lacks effective therapies. This review proposes that fibrotic states are maintained by chromatin-regulated circuits in fibroblasts and macr...

This Perspective highlights the use of current proteomics technologies in defining stage-specific reprogramming events to understand reproductive ageing, improve oocyte quality, and refine the outcome...

Kim et al. demonstrate a non-canonical function for EZH2 in modulating cholesterol metabolism and tumour development by interacting with SREBP2, which may be targeted by PROTACs to disrupt its oncogen...

Mitochondrial dysfunction features prominently in tauopathies. The mechanistic link between tau and mitochondria remains uncertain. Li et al. show that tau enters mitochondria and interacts with compl...

Cell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.

Nguyen et al. show that accumulation of dimethylarginine in lysosomes in disease models is associated with lipotoxicity and lipid droplet abundance.

Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...

At this critical moment when misinformation about sex is being applied to policy globally, scientific clarification on the definition of biological sex is valuable. Here, we evaluate the primary appr...

The origin of life is often framed primarily as a chemical problem, yet life's defining feature is evolution. Advances in geochemistry, prebiotic chemistry, and molecular biology have produced diverse...

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and dise...

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

Cell fate is shaped by external cues and intrinsic cellular states. While supracellular signals, such as growth factors, provide instructive guidance,…

YouTube video by Bruno Lemaitre

Nature Microbiology, Published online: 15 June 2026; doi:10.1038/s41564-026-02389-1Purine bias is critical for gene expression in bacteria, preventing premature transcription in species that exhibit runaway transcription.

ABSTRACT Unsaturated lipid double-bond (C═C) positional isomers are closely related to lipid structure and biological function, but their reliable qualitative and quantitative analysis remains challenging by conventional liquid chromatography–mass spectrometry (LC-MS) methods. In this study, we developed a microwave-assisted meta-chloroperoxybenzoic acid (m-CPBA) epoxidation method coupled with LC–tandem MS for the identification and quantification of unsaturated lipid C═C positional isomers. The reaction conditions were optimized to facilitate the formation of fully epoxidized products, simplify the chromatographic peak profiles, and enhance their suitability for targeted quantitative analysis. The developed method showed good analytical performance, including satisfactory linearity (r 2 > 0.99), precision (relative standard deviation

In Open Veins of Latin America (1971), Eduardo Galeano argued that colonial interventions in Latin America organised the regional economy around raw m…

STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterize...