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Heidi Ledford

@heidiledford.bsky.social
3.1K followers 1.3K following 51 posts

Reporter for Nature, mostly covering biology and medicine. Probably has more Nature publications than you😁. hledford.01 (Signal) and heidiledford (@proton.me)

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Heidi Ledford @heidiledford.bsky.social · 9h
"Similarly, menopause hormone therapy comes in >200 varieties that differ by dose, formulation of estrogens and progestogens, and timing, each with their own distinct risk-benefit profiles." 😲that's.... wow. How are we going to sort that out? www.science.org/doi/10.1126/...
science.org
Reframing menopause and menopause hormone therapy as opportunities for healthy aging
Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...
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Jeffrey Perkel (he/him) @jperkel.bsky.social · 10h
For the science feed. 🧪 By @heidiledford.bsky.social @nature.com
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Richard Van Noorden @richvn.bsky.social · 21h
It's NOBELS week next week! To whet your appetite, here's a challenge: how many of the women who've won a science #Nobel can you name? www.nature.com/immersive/d4... @nature.com | @nobelprize.org
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Dan Garisto @dangaristo.bsky.social · 17h
See our coverage from August on the impact of those withheld funds. Final tally is about ~6200 grants.
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Max Kozlov @maxkozlov.bsky.social · 25/09/2026
SCOOP: Top researchers at Columbia, Stanford, and others thought they were elected to elite scientific societies alongside Nobel laureates. The catch? The organizations are a sham. I spent the last month diving deep into a massive academic scam spanning continents, for @nature.com
nature.com
Exclusive: Sham scientific societies are misleading star researchers
A Nature investigation reveals a network of organizations that have been building their ranks through deceptive practices.
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Heidi Ledford @heidiledford.bsky.social · 15/09/2026
Food poisoning bug sends immune cells charging from the gut to the brain -- fun, fascinating story by @gvconroy.bsky.social @nature.com www.nature.com/articles/d41...
nature.com
'Stomach bugs' send protective immune cells rushing from gut to brain
Voyaging gut-derived immune cells ‘remember’ past stomach infections in mice.
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Heidi Ledford @heidiledford.bsky.social · 11/09/2026
Really enjoyed this @jesshamzelou.bsky.social roundup of under-35s to watch in biotech. A timely reminder (just ahead of Nobel season!) for folks like me to not just focus on the senior investigators... 🧪 www.technologyreview.com/2026/09/11/1...
technologyreview.com
Meet the under-35s shaping the future of biotech
They’re designing viruses, reversing the aging process, and saving lives.
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Heidi Ledford @heidiledford.bsky.social · 11/09/2026
Did an experimental cell therapy rebuild bones in people with osteoporosis? Elie Dolgin balances hope and caveats in this @nature.com story about a small, preliminary clinical trial of marrow cells that were modified to seek out bone www.nature.com/articles/d41...
nature.com
Osteoporosis affects millions: could modified cells rebuild their bones?
Small trial hints at regenerative potential of bone-seeking marrow cells.
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Davide Castelvecchi @castelvecchi.bsky.social · 08/09/2026
www.nature.com/articles/d41...
nature.com
OpenAI claims huge maths breakthrough on a famed ‘Millennium Problem’
The company says it has cracked the physics of fluids using AI, solving one of the toughest puzzles in mathematics.
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Kerri Smith @kerri-smith.bsky.social · 02/09/2026
Almost every infection can leave a subset of people with a chronic condition, #MECFS and #longCOVID among them. Why does that happen, and where are the treatments? www.nature.com/articles/d41... New feature from @nature.com
nature.com
When do infections lead to long COVID? Scientists close in on triggers and treatments for post-viral syndromes
Hundreds of millions of people have long-term conditions as a result of an infection. Researchers are working out how to help them.
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Nature @nature.com · 04/09/2026
An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense. go.nature.com/4ycEbk8
go.nature.com
Revealed: inside the US military's plan to tap huge sums from the NIH
An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defence.
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Heidi Ledford @heidiledford.bsky.social · 02/09/2026
A landmark pancreatic cancer drug is showing promise against the world’s biggest cancer killer: lung cancer. It’s early days – the clinical trial was small, and drug resistance remains a problem – but I'll take good news where I can find it. www.nature.com/articles/d41...
nature.com
Landmark pancreatic cancer drug shows potential against lung cancer too
Results bolster hopes that the drug daraxonrasib could prove effective against a variety of tumours.
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James Dinneen @jamesdinneen.bsky.social · 12/08/2026
Ocean temperatures are hovering hundredths of a degree below the all-time record high with months to go before El Niño reaches full strength. “Basically, everywhere on Earth, we’re having above-normal temperatures in the ocean." New in @nature.com: 🌊🌍🧪 www.nature.com/articles/d41...
nature.com
Ocean temperatures set to break all-time record: what's next?
High sea surface temperatures are expected to weaken ocean carbon sinks and damage coral reefs.
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Max Kozlov @maxkozlov.bsky.social · 11/08/2026
NEW: The NIH is quietly restricting funding for research that evaluates how public policy impacts human health. According to internal documents I obtained, the agency no longer considers policymakers "mission relevant" — a massive shift for the biomedical funder. My latest for @nature.com:
nature.com
NIH limits funding for research on the health effects of public policy
US biomedical agency no longer considers policymakers as ‘mission relevant’, leaving dozens of grants in limbo.
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scienceartnews.bsky.social @scienceartnews.bsky.social · 03/08/2026
The bispecific antibodies, T-cell activators, attempt to bring the two cell types closer together, thereby stimulating the T-cell to attack the cancer cell. At least 12 such T-cell activators have been approved for the treatment of cancer, including leukemia & myeloma. @heidiledford.bsky.social
go.nature.com
Cancer-fighting antibodies with a one-two punch take aim at tumours
Bispecific antibodies, which bind to two targets, are sweeping into the clinic and are prompting even more elaborate versions.
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Jeffrey Perkel (he/him) @jperkel.bsky.social · 05/08/2026
Nature reveals the studies that are mentioned most often in patent filings — and why. A fascinating analysis by @richvn.bsky.social @heidiledford.bsky.social & Edward Chen at @nature.com 🧪 www.nature.com/articles/d41...
nature.com
Exclusive: the science papers that patents cite the most
Nature reveals the studies that are mentioned most often in patent filings — and why.
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Nature @nature.com · 17/07/2026
A cutting-edge operation has restored a man’s ability to make sperm by transplanting tissue samples that were removed from one of his testicles and frozen 16 years earlier. go.nature.com/4pz617m
go.nature.com
Man’s ability to make sperm restored after testicular tissue transplant: what scientists think
Testicle sample removed from a ten-year-old before chemotherapy and frozen proves viable 16 years later.
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NSWA - Northwest Science Writers @nswa.bsky.social · 14/07/2026
NSWA members: @robertakwok.bsky.social will be launching her new book, Lost in Curiosity, next week! 🚀 Hope to see you at one of these events:) Tuesday 7/21 at 7pm at Ravenna Books Wednesday 7/22 at 6:30 at Brick & Mortar Books Redmond Thursday 7/23 at 6pm at Village Books & Paper Dreams, Fairhaven
lnkd.in
Seattle-area folks, I'll be launching Lost in Curiosity at Third Place Books Ravenna and Brick & Mortar Books in Redmond next Tuesday/Wednesday! And if you're closer to Bellingham, I'l...
Seattle-area folks, I'll be launching Lost in Curiosity at Third Place Books Ravenna and Brick & Mortar Books in Redmond next Tuesday/Wednesday! And if you're closer to Bellingham, I'll be at Village ...
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Nature @nature.com · 25/06/2026
For the second time this month, a team of researchers has reported harnessing a precise gene-editing technique to alter the DNA of human embryos go.nature.com/4vwIXrO
go.nature.com
‘Edited’ human embryos reveal secrets of our development — and fuel ethical debate
Ethical discussions are urgently needed as genome-editing science advances, some researchers say.
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Alexandra Witze @alexwitze.bsky.social · 25/06/2026
🔴 We have a fun thing for you today in @nature.com - a game! We took the latest research into Mars terraforming and transformed it into an interactive adventure. 🌿 How would you make the red planet green? Try your hand and see if you can win. 🧪 www.nature.com/immersive/d4...
nature.com
Can you terraform Mars? Try Nature’s game
Once the realm of science fiction, the idea of making Mars habitable is gaining traction. Nature consulted with key scientists to develop this experimental adventure.
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Heidi Ledford @heidiledford.bsky.social · 12/06/2026
Not just an issue for AI: "Scientists and engineers who build powerful AI systems often understand the tools’ capabilities in extraordinary detail. What they resist — and sometimes cannot see — is that their technical choices are also political choices." www.nature.com/articles/d41...
nature.com
I advise the Vatican and the UN on AI — don’t dismiss the Pope’s message as theology
The papal letter goes beyond a religious document and diagnoses a failure in AI governance that the scientific community should heed.
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Helen Pearson @helenpearson.bsky.social · 14/05/2026
"The results... do not mean that 6-8 hours is the optimum amount of sleep for every person, nor do they prove that achieving that ‘Goldilocks’ range of sleep each day directly improves health or slows ageing." @heidiledford.bsky.social on sleep study & impt caveats www.nature.com/articles/d41...
nature.com
Sleep linked to slower ageing: huge study pinpoints the right amount
Health outcomes were better in people who slept between about six and eight hours a day.
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Philip Ball @philipcball.bsky.social · 25/04/2026
Characteristicaly good piece by @lizziegibney.bsky.social about how seriously (or not) to take AI doomsayers. The point is made here that AI researchers are not necessarily the best people to ask about social implications of the technology. To which I'd add that... www.nature.com/articles/d41...
nature.com
AI doom warnings are getting louder. Are they realistic?
Researchers are increasingly sounding the alarm that artificial intelligence could end humanity. But such doomsday warnings carry their own risks.
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Dan Garisto @dangaristo.bsky.social · 26/04/2026
My story on the NSB terminations:
nature.com
Entire NSF science advisory board fired by Trump administration
Members of the National Science Board, which the US Congress founded in 1950, were given no explanation for their termination.
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Magdalena Skipper @magdalenaskipper.bsky.social · 03/04/2026
NASA has just shared the first high-resolution images of the Earth taken by the Artemis II crew, meanwhile, massive budget cuts are once again proposed for US science, including for NASA 🧪 www.nature.com/articles/d41...
nature.com
Massive budget cuts for US science proposed again by Trump administration
Budget proposal would also curb federal payments for scientific publishing.
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Heidi Ledford @heidiledford.bsky.social · 18/03/2026
Ouch. “Despite the incredible wealth of interesting content at conferences, it can be hard to stay engaged. And by engaged, I mean awake." www.nature.com/articles/d41...
nature.com
Knock knock, no one’s there. Study finds scientists’ jokes mostly fall flat
Survey examines how often academics attempt jokes during conference talks — and how these attempts at comedy land.
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Nature @nature.com · 18/03/2026
CRISPR–Cas9 might offer a way to make safer, more effective cancer-fighting immune cells engineered inside the human body go.nature.com/4lE2kv2
go.nature.com
CRISPR makes enhanced cancer-fighting immune cells inside mice
Gene-editing technique promises a potentially safer way to create CAR T cells with a simple injection.
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Magdalena Skipper @magdalenaskipper.bsky.social · 14/03/2026
This is important! A locally tailored, big-push intervention to educate unmarried adolescent girls in 18 communities in northern Nigeria reduced rates of marriage from 86% to just 21% 🧪 #policy #education www.nature.com/articles/d41...
nature.com
Marriage of adolescent girls in Nigeria reduced by 80% by ‘big push’ intervention
A locally tailored, big-push intervention to educate unmarried adolescent girls in 18 communities in northern Nigeria reduced rates of marriage from 86% to just 21%. Interventions that address complex...
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Alexandra Witze @alexwitze.bsky.social · 04/03/2026
Thanks @scifri.bsky.social for having me on to talk about federal research budgets. TLDL: Congress voted to reject the president's big science cuts, but the White House is slow to release those approved funds. 🧪 podcasts.apple.com/us/podcast/s...
podcasts.apple.com
Slow Release Of Federal Science Funds Holds Up Research
Podcast Episode · Science Friday · March 4 · 13m
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Max Kozlov @maxkozlov.bsky.social · 27/02/2026
Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
nature.com
White House stalls release of approved US science budgets
The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.
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Natasha Gilbert @byng.bsky.social · 25/02/2026
More researchers face consequences for their links to #Epstein. Jack Horner, who was a consultant for the Jurassic park films, is no longer employed at Chapman University. See my story for Nature www.nature.com/articles/d41...
nature.com
Scientists face fallout for past associations with Epstein
Jack Horner, who was a consultant for the Jurassic Park films, is among the researchers whose work or careers have been affected because of revelations from newly released documents.
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Alexandra Witze @alexwitze.bsky.social · 12/02/2026
Today’s action “is a rejection of the most basic laws of physics”, says #climate scientist Friederike Otto. I report on the EPA revoking its own ruling on the danger of greenhouse gases: www.nature.com/articles/d41... 🧪
nature.com
US repeals key ‘endangerment finding’ that climate change is a public threat
Overturning the 2009 decision means billions of extra tonnes of greenhouse-gas emissions over the next three decades.
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Max Kozlov @maxkozlov.bsky.social · 03/02/2026
I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee. Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here: www.help.senate.gov/hearings/mod...
help.senate.gov
Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions
Full Committee Hearing on February 3, 2026 at 5:00 AM
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Timothy Caulfield @caulfieldtim.bsky.social · 05/12/2025
Aluminium is crucial to vaccines — and safe. Why are US advisers debating it? www.nature.com/articles/d41... by @heidiledford.bsky.social via @nature.com "You cannot just get rid of an adjuvant that works and is safe before you have something else that you know will be a good replacement."
nature.com
Aluminium is crucial to vaccines — and safe. Why are US advisers debating it?
RFK Jr’s vaccine advisory panel will be discussing the inclusion of adjuvants in childhood vaccinations this week. Here’s what’s at stake.
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Brendan Maher @bmaher.bsky.social · 10/09/2025
Inspired by Fred Rogers, @nature.com asked readers to help us 'find the helpers' amid the crisis in American science. What emerged were inspiring stories of researchers, legal experts, data hounds and government scientists who are fighting the dismantling of the US research enterprise. 🧪🧵1/6
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Dan Garisto @dangaristo.bsky.social · 10/09/2025
Often the news happens so quickly that there's little time for it, so we took a step back to talk about the stories of the researchers who have been fighting back against the Trump administration's assault on science. w/ @maxkozlov.bsky.social and @heidiledford.bsky.social
nature.com
Scientists take on Trump: the researchers fighting back
Through lawsuits, grant tracking, whistle-blowing and more, resistance to the US war on science is growing.
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Heidi Ledford @heidiledford.bsky.social · 03/09/2025
YES!!!! So happy to see @maxkozlov.bsky.social recognized for the total rockstar he is: casw.org/news/max-koz... So many more schmancy journalism awards in this guy's future.
media.tenor.com
a group of people are dancing in a room with the words `` happy dance '' .
ALT: a group of people are dancing in a room with the words `` happy dance '' .
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Nature @nature.com · 23/08/2025
Scientists are closing in on the ability to apply genome editing to a formidable new target: the human brain go.nature.com/45uKWT1
go.nature.com
Brain editing now ‘closer to reality’: the gene-altering tools tackling deadly disorders
Nature - Stunning results in mice herald gene-editing advances for neurological diseases.
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Nature @nature.com · 22/08/2025
The claim that aluminium in vaccines causes autism has been debunked “again and again” go.nature.com/4mY7OQQ
go.nature.com
RFK Jr demanded a vaccine study be retracted — the journal said no
In a rare move for a US public official, health secretary Robert F. Kennedy Jr called for a Danish paper finding no link between aluminium in vaccines and disease to be retracted.
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Alexandra Witze @alexwitze.bsky.social · 12/08/2025
In which @stephaniemlee.bsky.social reports for @theopennotebook.bsky.social on using public documents for investigative science journalism. With @laurenweberhp.bsky.social @naveenasadasivam.bsky.social @primateyell.bsky.social @dangaristo.bsky.social & more: www.theopennotebook.com/2025/08/12/h...
theopennotebook.com
Hidden in Plain Sight: Using Public Documents to Report on Elusive Stories - The Open Notebook
People, companies, and government agencies don’t always return your phone calls. To investigate secretive subjects, reporters can make creative use of documents that are out in the open. Lawsuits, Ins...
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Waggoner Lab @labwaggoner.bsky.social · 26/07/2025
Ageing accelerates around age 50 ― some organs faster than others, suggesting that ageing does not march to a steady beat @nature.com @heidiledford.bsky.social www.nature.com/articles/d41...
nature.com
Ageing accelerates around age 50 ― some organs faster than others
An analysis of how various tissues age is the latest to suggest that ageing does not march to a steady beat.
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Waggoner Lab @labwaggoner.bsky.social · 07/07/2025
Turbocharged ‘killer’ cells show promise for autoimmune disease @nature.com @heidiledford.bsky.social nature.com/articles/d41... on @cellcellpress.bsky.social doi.org/10.1016/j.ce...
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Max Kozlov @maxkozlov.bsky.social · 25/06/2025
NIH director Jay Bhattacharya posted on X: "No clinical trial has been delayed, nor has any participant been dropped from clinical trial. These are the facts." Malaria, tuberculosis, cancer trials abroad have all been on the chopping block, leaving participants stranded, I reported in this story.
nature.com
NIH grant cuts will axe clinical trials abroad — and could leave thousands without care
US agency’s new policy could abruptly end studies of infectious diseases and cancer, leaving researchers scrambling for funds.
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Max Kozlov @maxkozlov.bsky.social · 17/06/2025
After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵
nature.com
Judge rules against NIH grant cuts — and calls them discriminatory
The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.
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Max Kozlov @maxkozlov.bsky.social · 16/06/2025
An NIH staffer reacts to today's ruling: "I'm looking forward to the day that we are so slammed with work trying to reinstate everything that we had to terminate illegally — I'll work 24/7 to make that happen if I can."
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Greg Priest @gregpriest.bsky.social · 16/06/2025
Barbara McClintock was born OTD in 1902. “I start with the seedling, and I don't want to leave it. I don't feel I really know the story if I don't watch the plant all the way along. So I know every plant in the field. I know them intimately, and I find it a real pleasure.” 🌱🐋🧪 #HistSTM #PhilSci
Caricature of McClintock by David Levine for The New York Review of Books.
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Max Kozlov @maxkozlov.bsky.social · 12/06/2025
A lightning-fast, in-depth look into who RFK Jr selected for the vaccine advisory committee. One of whom was an expert witness against Merck's vaccine, despite RFK's stated reason of reducing conflicts of interest, per @reuters.com. Well done @heidiledford.bsky.social and @rfieldmouse.bsky.social
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Heidi Ledford @heidiledford.bsky.social · 21/05/2025
"US scientists who find themselves abruptly unemployed are turning desperation and defiance into fresh coping strategies and advice. But one thing is clear: whether they move abroad, pivot to other research areas or leave science altogether, their deep expertise is likely to be lost." 🧪
nature.com
#OpenToWork: how laid-off US scientists are coping with shattered careers
Unemployed researchers face some tough career choices as they flood the job market after the Trump administration’s cuts to science.
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Hensley Lab @scottehensley.bsky.social · 21/05/2025
Check out this news story that @nature.com wrote describing our recent preprint where we tested our H5 mRNA vaccine in calves. The data look good and we are currently testing the vaccine in lactating cattle...more to come!
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Nature @nature.com · 19/05/2025
The CRISPR family’s most versatile member has made its medical debut: a cutting-edge gene-editing technique known as prime editing has been used to treat a person for the first time go.nature.com/3YNta9V
go.nature.com
World first: ultra-powerful CRISPR treatment trialled in a person
Immune-cell function improved in a teenager whose DNA was altered using prime editing.
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