Wang et al. introduce HoTs, self-blinking DNA probes for live-cell super-resolution chromatin imaging. Compatible with both STORM and MINFLUX microscopy, HoTs capture chromatin organization across live cells, animal tissues, and clinical tumor samples, opening new opportunities for studying genome architecture in health and disease.

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor bindi...

Chromosome conformation analysis in Drosophila wing discs reveals the requirement of specific meta-loops during regeneration.

Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...

Nature Communications - How non-coding mutations in DNA contribute to phenotypes is a largely unresolved question. Here the authors integrate personal genomics and machine learning to identify...

Stem cell identity and differentiation require precise gene regulation, yet key regulatory components remain poorly understood. Here, the authors show that variant U1 snRNAs have distinct and essentia...

Genome Biology - Although significant progress has been made in our understanding of DNA replication and spatial chromosome organization in eukaryotes, how they interplay remains elusive. In...

Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.

The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...

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Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

The Perturb-Tracing approach represents a significant step forward in our ability to perform pooled loss-of-function perturbations to identify regulators of 3D genome organization across multiple leng...

MPORTANT MOBILITY RULE FOR THIS POSITION The MSCA mobility rule applies to this position: the applicant must not have resided or carried out their main activity (e.g., studies, work, research) in Spai...

MPORTANT MOBILITY RULE FOR THIS POSITION The MSCA mobility rule applies to this position: the applicant must not have resided or carried out their main activity (e.g., studies, work, research) in Spai...

Commitment & contract: Post Doc 1 year collaboration contract, renewable Location: Centre for Human Technologies – Genoa At the Italian Institute of Technology (IIT), we are committed to advancing h...