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Siyuan (Steven) Wang

@sstevenwang.bsky.social
40 followers 16 following 31 posts

Image-based spatial multi-omics. Associate Professor at Yale. NIH Director's New Innovator Awardee. MIT Technology Review 35 Innovators Under 35.

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Siyuan (Steven) Wang @sstevenwang.bsky.social · 25/09/2026
Thank you Professor Anna Woloszynska and colleagues at @roswellpark.bsky.social Roswell Park Comprehensive Cancer Center for inviting me to give a keynote lecture in the 6th Translational Genomics and Epigenomics Symposium!
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 24/07/2026
Glad to share our latest publication in Science! This work reports: 🧬 the first single-cell 3D genome atlas of human tonsil and B cell immunity, 🧬 a new function for cohesin loop extrusion, and 🧬 a novel chromatin "curl" structure. www.science.org/doi/10.1126/...
science.org
A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation
B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influen...
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 15/01/2026
Thank you the student union of the biochemistry department and Professor Ahilya Sawh @hilsawh.bsky.social of the University of Toronto for inviting me to present in the George Connell Lecture Series! It was so wonderful to meet and discuss science with colleagues and students in the esteemed UofT.
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Guido Barzaghi @guidobarzaghi.bsky.social · 28/11/2025
Read our @natgenet.nature.com News&Views on the impressive work by @muzumdarlab.bsky.social and @sstevenwang.bsky.social. How does the 3D genome guide Kras-driven cancers evolution? Find out with single-cell genome-wide chromatin tracing! 📖https://rdcu.be/eShAY
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 13/11/2025
Thank you Dian and Xuebing for inviting me to visit the Department of Systems Biology at Columbia. Such engaging and inspiring audience at the talk. It felt like everyone had asked at least one question by the end. Thank you all for having me and for this invigorating day of scientific exchanges!
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 08/10/2025
Check out our new RAEFISH spatial transcriptomics technology published in Cell! This work represents the first time that transcripts from more than 20,000 genes were directly imaged in situ with any technology, and the first time numerous gRNAs were directly probed in an image-based CRISPR screen.
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GenomeTDCC @genometdcc.org · 01/10/2025
New highlight video! 🧪🧬💻 RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up www.youtube.com/watch?v=P2j6...
youtube.com
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
YouTube video by GenomeTDCC
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Reposted by Siyuan (Steven) Wang
Nature Genetics @natgenet.nature.com · 27/08/2025
🎉PUBLISHED @natgenet.nature.com 📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers. By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...
nature.com
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics
This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...
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Reposted by Siyuan (Steven) Wang
Yale Cancer Center @yalecancer.bsky.social · 19/08/2025
New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers. ➡️ yalecancercenter.org/news-article...
yalecancercenter.org
Cancer's Progress Detailed by 3D Genomic Maps
Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 19/08/2025
Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 09/08/2025
Check out this new video highlighting our lab :-) Thank you @yaleschoolofmed.bsky.social Video Team for the production! m.youtube.com/watch?v=p-hE...
m.youtube.com
Genome Architectures & Spatial Transcriptomics - The Siyuan Wang Lab at Yale School of Medicine
YouTube video by Yale Medicine
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GenomeTDCC @genometdcc.org · 30/07/2025
How does 6ft of #DNA fit inside a cell only 10 microns wide? @sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS www.youtube.com/watch?v=gXCO...
youtube.com
A Brief History of Contemporary 3D Genomics Technologies
YouTube video by GenomeTDCC
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 26/06/2025
Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8
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Siyuan (Steven) Wang @sstevenwang.bsky.social · 26/06/2025
Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8
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