Reposted by Guy NirMarc A. Marti-Renom @mamartirenom.bsky.social · 27/06/2025How to represent genomes in 3D? In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅 👉🏼 genomebiology.biomedcentral.com/articles/10.... 24419
Reposted by Guy NirStand Up for Science! @standupforscience.net · 29/06/2025The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work. Thousands of lives at risk for tax cuts for the rich? NO THANKS. Tell your senators to oppose the cuts HERE: zurl.co/qiKdX zurl.co/RCR0y #CutsCostLiveszurl.coWill the Senate Save NIH?Rescuing biomedical research is every bit as important as saving Medicaid. 216481
Guy Nir @guynir.bsky.social · 16/06/2025Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion. With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...biorxiv.org 173
Reposted by Guy NirDaniel Ibrahim @danielibrahim.bsky.social · 27/05/2025How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...rdcu.beConservation of regulatory elements with highly diverged sequences across large evolutionary distancesNature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence... 7247111