Limb loss remains a significant clinical challenge, but regenerative medicine approaches such as gene therapy offer a promising strategy to trigger...

In the giant Pleurodeles waltl genome, introns serve as “structural buffers,” absorbing transposable elements (TEs) to protect coding exons. While this enables “gene body inflation,” persistent TE ac...

The findings strengthen the case that regeneration is an old trait, offering insights into how complex tissues rebuild themselves.

Limb loss remains a significant clinical challenge, but regenerative medicine approaches such as gene therapy offer a promising strategy to trigger endogenous regeneration programs. Optimal vector con...

How axolotl salamanders know what portion of the limb to regenerate remains a mystery. In this article, the authors show that precise retinoic acid degradation is critical for instructing regener...

A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.

Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.

Nature Reviews Genetics, Published online: 13 January 2025; doi:10.1038/s41576-024-00807-wEpigenetic clocks based on DNA methylation data are machine learning tools used to estimate chronological and biological age. The authors review computational and…

Chordate tail regeneration represents the remarkable ability of some chordates to partially or completely regenerate a significant portion of their pr…

遺伝学の中核拠点として生命システムの解明を目指す先端研究を進めています。また、生命科学の基盤となる研究事業を展開しています。これらの活動により、共同利用・共同研究を推進しています。総合研究大学院大学 生命科学研究科 遺伝学専攻を併設し、優秀な研究者を世に送り出しています。